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17 Cards in this Set
- Front
- Back
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T or F. ED50>KD50
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false
ED50 < KD50 there are almost always more recpetors than necessary to get 50% response, so you don't have to bind 50% of all total receptors |
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which is more important: efficacy or potency?
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always efficacy
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efficacy is based on the _ axis while potency is based on the _ axis
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Y
X |
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TI =
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TD50/ED50
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CSF =
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TD1/ED99
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a ______ _______ appears to be an antagonist in the presence of full agonist because of occupation of the agonist's receptor sites while giving a lesser response
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partial agonist
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what is an inverse agonist?
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inhibits agonist dependent and agonist indepedent receptor activity
stabilizes the inactive form of the receptor leads to decreased effect |
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T or F. an antagonist has no instrinsic efficacy
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true has zero efficacy but that doesn't mena that there is zero biological effect
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is competitive inhibition surmountable?
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yes
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a ______ inhibitor produces nonfunctional complex or has post receptor site of action
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noncompetitive
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a ______ is a form of noncompetitive antagonism
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irreversible
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a ______ agnatgonist acts directly on the agonist itself, chemically altering the agonist
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chemical
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what is physiological antagonism
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drug produces opposing responses by acting on different systems
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is competitive antagonism surmountable? noncompetitive? irreversible?
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yes
no no |
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the curve shifts right in _____ antagonism
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competitive
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what happens to ED50 in competitive? noncompetitive? irreversible?
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increases
same same |
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what happens to maximum effect in noncomp and irreversible antagonism?
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decreased
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