Fm1 Exam I Path 3

Front 1

is inflammation innate or acquired immunity

Back 1

innate

Front 2

what are four classic signs of inflammation

Back 2

rubor
calor
dolor
tumor

Front 3

name all the types of WBCs

Back 3

never let me eat bacon
neutrophils
lymphocytes
monocytes
eosinophils
basophils
(platelets)

Front 4

_____ are the primary cell responder in acute inflammation

Back 4

neutrophils

Front 5

what do neutrophils look like

Back 5

segmented nucleus with 3 to 5 lobes and numberous cytoplasmic granules

Front 6

_______ are single nucleus with very scant cytoplasm

Back 6

lymphocytes

Front 7

_______ are primarily involved in chronic inflammation and in acquired immunity

Back 7

lymphocytes

Front 8

_____ cells are specialized lymphocytes that elaborate antibodies when stimulated

Back 8

plasma cells (lymphocytes)

Front 9

_____ are involved in both acute and chronic inflammation

Back 9

monocytes

Front 10

______ are an important link of acute and chronic inflammation

Back 10

monocytes

Front 11

_____ have a bilobed nucleus with deeply blue basophilic granules

Back 11

basophiles

Front 12

what is inside basophils

Back 12

histamine, proteoglycans, proteolytic enzymes, lipid mediators of inflammaiton

Front 13

cells in the tissue that are sturcturally and physiologically identical to basophils are called ____ cells

Back 13

mast

Front 14

what cells have slow reacting substances of anaphylaxis involved in allergic and hypersensitivity reactions

Back 14

basophils

Front 15

what cells are invovled in allergens an dparasites

Back 15

eosinophiles

Front 16

what is inside an eosinophil

Back 16

pink eosinophilic granules with histamine, proteolytic enzymes, and basic proteins

Front 17

what are the percentages of WBCs

Back 17

NLMEB
50 to 70
25-35
4-6
1-3
.5-1

Front 18

what types of cells are involved in acute inflammation?

Back 18

Granulocytes
Basophils
eosinophils
neutrophils

Front 19

what cells are involved in chronic inflammation?

Back 19

mononuclear cells LM
lymphocyte
monocytes

Front 20

do endothelial cells constrict or dilate in response to vasoactive mediators of inflammation and cytokines

Back 20

constrict! along with release of tight junctions

Front 21

start at page 30

Back 21

yes

Front 22

list the events of leukocyte adhesion and transmigration

Back 22

adhesion
- stasis
- margination
- adherence
tranmigration
- diapedesis
- migration via chemotactic gradient

Front 23

macrophages produce cytokines _____ and ____ that induce selectins

Back 23

TNF and IL1

Front 24

____ bind sialyl lewis X modifice dblycoproteins on the WBC

Back 24

selectins

Front 25

cytokines released from macrophages induce expression by endothelial cell sof _____ _____ such as ICAM1 and VCAM1

Back 25

integrin ligands

Front 26

_____ produced by macrophages stimulate the expression of proteoglycans on the endothelial cell surfaces that induce the integrins on leukocyte cell surfaces to switch from low affinity to high affinity state

Back 26

chemokines

Front 27

what integrin ligand on the endothelial cell mediates diapedesis of WBCs

Back 27

PECAM 1

Front 28

T or F. chemotaxis can occur via exogenous agents such as bacterial products or endogenous production of chemical mediators of inflammation

Back 28

true

Front 29

LFB, C5a, IL8, adn LTB4 are all

Back 29

chemicals of chemotaxis

Front 30

chemotactic agents bind to _____ onth eleukocyte cell membrane

Back 30

g portein coupled receptors

Front 31

_____ is the process of elimination of an injurious agents by WBCs

Back 31

phagocytosis

Front 32

how do WBCs recognize injurious agents

Back 32

macrophage mannose receptor (not present on host cells)
obsoinzed agents

Front 33

what are two ways that killing nad degredation occur

Back 33

oxygen dependent:

ROS (NADPH oxidase, MPO)

oxygen independent: acid hydrolase, lysozyme, cathepsin G, sulfatses)

Front 34

name a few diseases that are caused by release or leak of leukocyte products

Back 34

arthritis
acute transplant rejection
vasculitis
atherosclerosis
asthma
gout

Front 35

what might cause leakage of lysosomal contents

Back 35

regurgitation during feeding (phagolysosome opens to outside as phagosome is being internalized)

frustrated phagocytosis (e.g. glomerulonephritis)
cytotoxic release
exocytosis

Front 36

What is LAD types one and 2

Back 36

a genetic deficiency in leukocyte adhesion molecules that leads to recurrent bacti infections and impaired wound healing

Front 37

name two diseases caused by defects in phagolysosome function

Back 37

chediak higashi syndrome: (no lysosomal trafficking regulator)

chronic granulomatous diases (CGD): (def. in NADPH oxidase)

Front 38

what is the most common cause of decrease leukocyte activity clinically?

Back 38

bone marrow suppression

Front 39

name five morphological types of acute inflammation

Back 39

serous
fibrinous
gangrenous
pseudomembranous
suppurative
ulcerative

Front 40

_____ inflammation is characteristic of inflammation of the lining of body cavities like pleural pericardial and peritoneal

Back 40

fibrinous

Front 41

what is pus made of

Back 41

neutrophils
necrotic cells
edema fluid

Front 42

what type of inflammation is C dif

Back 42

pseudomembranous

Front 43

_____ inflammation is defined as the destruction of EPITHELIAL lining due to ischemic damage

Back 43

ulcerative inflammation

Front 44

where do you find fourniers gangrene

Back 44

scrot