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4 Cards in this Set
- Front
- Back
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Floroquinolones
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1st group… Norfloxacin…..least active
2nd group..Ciprofloxacin, Lomeflaxacin Ofloxacin ,Levofloxacin ,Pefloxacin 3rd group..,Sparfloxacin, Moxifloxacin Travofloxacin Gatifloxacin be able to identify which drugs are Floroquinolones |
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Floroquinolones action
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binding to subunit ‘A’, Inhibits DNA gyrase inhibits the negative supercoiling of DNA
Inhibits Topoisomerase II (humans) Deficit of negative supercoiling to relax the positive supercoiling results in irreparable breakages in the DNA strand |
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Ciprofloxacin
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DOC; COMPLIATED urinary tract infections, DOC for pseudomonas
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Adverse effects of flouroquinolones
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Arthropathy in children (don’t give this drug to pregnant patients or children or elderly)
Ruptured tendons- KEY ONLY use btwn ptn 20-40 (older or younger get joint prob w/ ruptures) |
