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53 Cards in this Set
- Front
- Back
contraindicated if
sulfonamide allergy |
Celebrex
|
|
Only 1 in 5 people who develop a serious upper
GI adverse event on NSAID therapy is |
symptomatic
|
|
Risk of gi bleed with NSAIDS increases with concurrent oral
|
corticosteroids, anticoagulants
|
|
__ can cause fluid retention and peripheral
edema, particularly __ |
NSAIDS, indomethacin
|
|
Potentially fatal hypersensitivity syndrome
|
Clinoril
|
|
Anaphylactoid reactions
are typically in asthmatic patients and more common in patients that are |
hypersensitive
to aspirin |
|
Reduce dose of NSAIDS in patients with
|
renal or liver function
impairment; also the elderly |
|
NSAIDS not recommended in cases of advanced
kidney disease |
Feldene -piroxicam, Mobic-meloxicam
|
|
metabolites may contribute
to kidney stones; keep hydrated |
Clinoril-sulindac
|
|
Nausea, fatigue, lethargy, pruritis, jaundice, upper
right quadrant tenderness, flu-like symptoms are signs of |
hepatotoxicity
|
|
Black Box Warning
For short term (up to 5 days) only For moderate-severe pain High risk of GI effects and Renal effects |
Toradol
|
|
should be avoided within 2-3 hours of the
Aspirin dose |
NSAIDS (non-specific)
|
|
schedule of Hydrocodone products
|
CIII
|
|
All codeine, oxycodone and hydrocodone products are immediate release except
|
OxyIR
|
|
narcotic also available as injection and lozenge
|
fentayl
|
|
Dolophine
|
methadone
|
|
narcotic; immediate release tablets and injection;
also available in solution and powder |
methadone
|
|
Contraindications:
Acute or severe bronchial asthma Upper airway obstruction Significant respiratory depression Premature infants When delivery of a premature infant is anticipated |
narcotic agonists
|
|
narcotics with suicidal implications
|
darvon, darvocet
|
|
Oxycodone is category
|
B
|
|
Do appear in breast milk, but effect may not be significant
Recommend to wait 4-6 hrs after use before breast feeding |
narcotic agonists
|
|
Fentanyl
Black Box Warning: |
Hypoventilation
|
|
Duragesic Patch: Start at lowest dose…particularly elderly d/t
|
muscle wasting and poor fat stores
|
|
If use is required for more than 3 weeks, oral form can be dispensed at an approved maintenance program only
|
methadone
|
|
narcotic agonist potentially inappropriate in the elderly
|
Darvon, Darvocet
|
|
morphine precaution
|
seizures
|
|
Most patients who receive opiates for medical
reasons do not develop |
dependence
|
|
Cigarette smoking may decrease pain relief from
|
Darvon, Darvocet-propoxyphene
|
|
two drugs which interact with Darvon, Darvocet-propoxyphene
|
Tegretol and anticoags
|
|
drug interaction with morphine
|
anticoags
|
|
for spasticity from multiple
sclerosis, spinal cord injury, other spinal cord diseases |
Lioresal- baclofen
|
|
for muscle spasticity
|
Zanaflex - tizanidine
|
|
Because of similarities to tricyclic
antidepressants, consider all interactions listed for tricyclic antidepressants |
flexeril
|
|
hyperpyretic crisis, severe
convusions, and death have occurred in patients receiving tricyclic antidepressants and |
MAOIs
|
|
__ may cause dry mouth (especially __)
|
skeletal muscle relaxants, flexeril
|
|
Orally, start low and titrate up to therapuetic dose
* Abrupt withdrawal can result in hallucinations and seizures |
baclofen
|
|
Intrathecal, screening phase with bolus dose before implant pump
* Abrupt discontinuation can result in high fever, altered mental status, rebound spasticity, muscle rigidity |
baclofen
|
|
CAUTION in patients with psychotic features…can worsen
|
baclofen
|
|
Like Baclofen, start at low, sub-therapeutic dose to determine
intolerance, then titrate up to therapeutic dose range |
zanaflex
|
|
Drowsiness, Dizzyness, Somnolence, Dry Mouth
|
zanaflex
|
|
Hypotension... caution with other alpha-adrenergic agonists (ie: Clonidine)
|
zanaflex
|
|
Possible idiosyncratic Hypersensitivity
- Weakness, Disorientation, Confusion, Agitation |
soma
|
|
Skeletal muscle relaxants available injection as well as oral
|
Robaxin and Norflex
|
|
Structurally related to tricyclic antidepressants…so higher incidence of drug
interactions on anticholinergic effects |
flexeril
|
|
Known practically as the least sedating muscle relaxant
- Caution in hepatic impairment |
skelaxin
|
|
for cluster headache
|
Imitrex-sumatriptan
injection only |
|
Class of:
Maxalt Zomig Frova Relpax Amerge Axert |
Serotonin 5-HT1 Receptor Agonists
|
|
May discolor urine brown, black, or green
|
robaxin
|
|
category for flexeril
|
B
|
|
Insomnia (specific agents)
|
Restoril, Halcion, Dalmane
|
|
Klonopin, Valium, Tranxene, Ativan (IV)
|
seizures
|
|
Librium, Klonopin, Tranxene, Valium,
Dalmane; long or short? |
long
|
|
Ativan, Xanax, Restoril, Halcion; long or short
|
short
|