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187 Cards in this Set

  • Front
  • Back

What are the layers of the esophagus?

stratified squamous epithelium (mucosa), circular inner muscle layer, outer longitudinal muscle layer; no serosa
What kind of muscle is in the upper esophagus? lower esophagus?

striated muscle, smooth muscle

What is the blood supply of the cervical esophagus? and abdominal esophagus?

Cervical esophagus – supplied by the inferior thyroid artery
Abdominal esophagus – supplied by the left gastric artery and inferior phrenic arteries

Which direction does the lymphatics of the esophagus drain?

upper 2/3 drains cephalad, lower 1/3 caudad

Right vagus nerve – travels on ____ portion of stomach as it exits chest; becomes ____ plexus; also has the criminal nerve of ___ → can cause persistently high acid levels postoperatively if left undivided
posterior, celiac, Grassi

Left vagus nerve – travels on what portion of stomach? and goes where?

anterior, goes to liver and biliary tree

The upper esophageal sphincter is how far from the incisors? and lower?

15 cm, 40 cm

What is the most common site of esophageal perforation (usually occurs with EGD)?

cricopharyngeus muscle

What muscle comprises the upper esophageal sphincter and prevents air swallowing?

cricopharyngeus muscle
What are the 3 anatomic areas of narrowing of the esophagus?
cricopharyngeus muscle,
compression by the left mainstem bronchus and aortic arch,
diaphragm
What is the surgical approach to the cervical esophagus? upper 2/3 thoracic? Lower 1/3 thoracic?
Cervical esophagus – left
Upper ⅔ thoracic – right (avoids the aorta)
Lower ⅓ thoracic – left (left–sided course in this region)
What is the cause in primary esophageal dysfunction? secondary?
unknown in primary

secondary includes systemic disease, gastroesophageal reflux disease (GERD; most common), scleroderma, polymyositis
What is the diagnostic procedure of choice for dysphagia and odynophagia?
barium swallow (better at picking up masses)
What is the usual cause of cervical esophageal dysphagia?
plummer–vinson syndrome
What is the 3 parts of tx for plummer–vinson syndrome?
dilation, Fe, screen for oral CA
What can occur between the cripharyngeus and pharyngeal constrictors?
Zenker's diverticulum
What is the tx for Zenker's diverticulum?
cricopharyngeal myotomy; Zenker's itself can either be resected or suspended
What do you get on POD #1 after a cricopharyngeal myotomy for Zenker's?
esophagogram
How is a traction diverticulum different from Zenker's?
Zenker's is a false diverticulum and lies posterior; traction is a true diverticulum is usually lateral in the mid esophagus
What is the tx for a traction diverticulum of the esophagus?
excision and primary closure; may need palliative therapy if due to invasive CA
What is caused by failure of peristalsis and lack of LES relaxation after food bolus, and is secondary to neuronal degeneration in muscle wall?
Achalasia
What is the medical tx for achalasia (2)? what is next step?

first, LES dilation (effective in 80%)

CCB, nitrates

What is the next step in tx of achalasia if CCB, nitrates and LES dilation fail?
Heller myotomy
What infection can produce similar sx to achalasia?
T. cruzi
sx similar to achalasia. May have psych history, normal LES tone, strong unorganized contractions.
Diffuse esophageal spasm
What are 4 types of tx for diffuse esophageal spasm?
calcium channel blocker, trazodone; Heller myotomy if those fail (myotomy of upper and lower esophagus; right thoracotomy)
Causes dysphagia, loss of LES tone; most have strictures, fibrous replacement of smooth muscle
Scleroderma
GERD sx with bloating suggests what?



how to dx

aerophagia and delayed gastric emptying



may want gastric emptying study

What is the best test for GERD?
pH probe





also endoscopy, histology, manometry (resting LES < 6 mm Hg)

What is the surgical tx for GERD?
Nissen
What is name of the approach through the chest in a Nissen?
Belsey
During a Nissen, when not enough esophagus exists to pull down into abdomen, can staple along stomach and create a “new” esophagus. What is this called?
Collis gastroplasty
Name the type of hiatal hernia:

Sliding hernia from dilation of hiatus (most common); often associated with GERD
Type I
Name the type of hiatal hernia:

Paraesophageal; hole in the diaphragm alongside esophagus, normal GE junction.
Type II
What is a Type III hiatal hernia? and type IV?
Type III – combined ■ Type IV – entire stomach in the chest plus another organ (i.e., colon, spleen)
Almost all pts with Schatzki's ring have an associated ___
sliding hiatal hernia
What is the tx for Schatzki's ring?
dilatation of the ring usually sufficient



PPI




dont resect

What is the transformation in pts with Barrett's esophagus?
squamous metaplasia to columnar epithilium
Pts with Barrett's esophagus are at 50x increased risk for what?
adenocarcinoma
Severe Barrett's dysplasia is an indication for what?
Esophagectomy



or




Endoscopic surveillance (3-month intervals; 4 quadrant Bx’s at 1-cm intervals for entire length of HGD and Bx of any suspicious areas)

Uncomplicated Barrett's can be treated like GERD with PPI or Nissen and surgery will decrease esphagitis and further metaplasia but it will not prevent what?
malignancy or cause regression of the columnar lining
Pts with Barrett's esophagus who get a Nissen still need careful lifetime follow up with what?
annual follow-up EGD
Esophageal tumors are almost always malignant. How does it spread?
submucosal lymphatic channels
What is the best test for unresctablity in esophageal CA?
Chest/abdominal CT



hoarseness (RLN invasion), Horner’s syndrome (brachial plexus invasion), phrenic nerve invasion, malignant pleural effusion, malignant fistula, invasion of another structure (eg airway invasion, vertebra, lung)

What is the #1 esophageal CA?



What type occurs most often in the upper 2/3?

Adenocarcinoma lower 1/3

Squamous cell carcinoma

mets to what nodes indicate unresectability



celiac nodes – M1 disease and Supraclavicular nodes in esophageal CA

Distant metastases with esophageal CA is a contraindication to what? what is the survival?
esophagectomy, < 12 mos
What is the mortality from surgery in esophagectomy for CA? and what percentage is it curative?
5%, 20%
What is the primary blood supply to stomach after replacing esophagus in esphagectomy?
right gastroepiploic artery (have to divide left gastric and short gastrics)
What is the name of the type of esophagectomy with an abdominal incision and right thoracotomy –> exposes all of the esophagus; intrathoracic anasomsis
Ivor Lewis
What type of esophagectomy may be choice in young pts with benign disease when you want to preserve gastric function.
Colonic interposition
What do you need after esophagectomy on post op day 7?
contrast study to rule out leak
Name two chemo agents that can be used with esophageal CA for node positive disease or use preop to shrink tumors?
5FU and cisplatin
In esophageal CA with malignant fistulas, most die within 3 months due to what?
aspiration
What is the most common benign tumor of the esophagus?
Leiomyoma
Diagnosis of Leiomyoma is __, ___, and ___ to rule out CA.

Why don't you bx?

esophogram, endoscopic u/s, CT



can form scar and make subsequent resection difficult
Tx for Leiomyoma of the esophagus is excision via thoractomy.

What are the 2 indications?

>5 cm or sx
Caustic esophageal injury:
NG tube?
Induce vomiting?
drink?
no, no, no
What is first step in dx in caustic esophageal injury? then what?


best test- endoscopy to assess lesion (but not with suspected perforation)



Chest and Abd CT to look for free air,

What is the most common cause of esophageal perforation?
EGD
What is the most common site of esophageal perforation?
cricopharyngeus muscle
How to dx esophageal perforation?
cxr initially

gastrograffin swallow followed by barium swallow




no egd

What is the tx for esophageal perforation that is contained, self–draining and no systemic effects?
Conservative: IVF, NPO, spit
What type of flap can be used with repair of esophageal perforation to help the area heal?
intercostal muscle pedicle flap
What is Hartmann's sign?
mediastinal crunching on ascultation
How to dx Boerhaave's syndrome?
gastrofrafin swallow
What is the stomach transit time?
3–4 hours
Where does peristalsis occur in the stomach?
only in the distal stomach
What are the branches of the Celiac trunk?
left gastric, common hepatic, splenic
Left gastroepiploic and short gastrics are branches of what artery?
splenic
What is the blood supply of the greater curvature of the stomach?
right and left gastroepiploics, short gastrics
What is the blood supply of the lesser curvature of the stomach?
right and left gastrics
The right gastric is a branch of what artery?
common hepatic
What is the blood supply of the pylorus?
gastroduodenal artery
What is the mucosa of the stomach lined with?
simple columnar epithelium
What is the first enzyme in proteolysis and what cell secretes it?
Pepsinogen, secreted by chief cells
What do the parietal cells secrete?
H+ and intrinsic factor
What 2 things do Brunner's glands in the duodenum secrete?
pepsinogen and alkaline mucus
Antrectomy with gastroduodenal anastomosis?
Billroth I
Antrectomy with gastrojejunal anastomosis?
Billroth II
____ ulcer is a vascular malformation in the stomach
Dieulafoy's
____ disease is mucous cell hyperplasia, increased rugal folds of the stomach.
Menetrier's
What is the tx for gastric volvulus?
reductiona and Nissen
Associated with type II (paraesophageal) hernia ■ Nausea without vomiting; severe pain.
Gastric volvulus
Where is the tear usually located in a Mallory–Weiss tear?
near lesser curvature of the stomach near GE junction
What is the result of a vagotomy
vagal denervation all forms increase liquid emptying –> vagally mediated receptive relaxation is removed, results in increased gastric pressure that accelerates liquid emptying
In complete vagotomy (truncal or selective) there is decreased emptying of solids. In highly selective vagotomy there is normal emptying of solids. Addition of what procedure to either results in increased solid emptying?
Pyloroplasty
What is the most common problem following vagotomy (30–50%)?
diarrhea
Upper GI bleed and having trouble localizing source with EGD. What can be done next?
tagged RBC scan
What is the biggest risk factor for rebleeding of an upper GI bleed at the time of EGD?
spurting blood vessel
In a pt with liver failure, what is the most likely source of an upper GI bleed?
esophageal varices
What is the tx for a bleeding esophageal varices?
EGD with sclerotherapy or TIPS, not OR
What location of duodenal ulcers usually perforate? what location bleed from GDA?
anterior ulcers perforate, posterior ulcers bleed from GDA
Describe the incision and closure of a Heineke–Mikulicz pyloroplasty.
longitudunal incision of the plyloric sphincter followed by a transverse closure
What is the most frequent complication of duodenal ulcers?
bleeding
The 1st surgical option for bleeding duodenal ulcer is duodenstomy and what? what if the pt has been on PPI therapy?
GDA ligation,

truncal vagotomy and pyloroplasty
With GDA ligation for bleeding duodenal ulcer, it is important to avoid hitting what structure?
common bile duct
What is the initial treatment of choice for obstruction due to duodenal ulcer?
serial dilation
Pt on H–pump inhibitor develops a perforated duodenal ulcer. What is the best surgical option? what if they were not on H–pump inhibitor?
Graham patch and highly selective vagotomy; just do Graham patch and place on omeprazole
What is the test for Zollinger–Ellison Syndrome?
Secretin test results in high gastrin level
In Zollinger–Ellison syndrome, what size tumors can be enucleated?
<2 cm
What is the most common location for gastric ulcers? and the most common cause?
lesser curvature; decreased mucosal defense (normal acid secretion)
Hemorrhage is associated with higher mortality in duodenal or gastric ulcers?
gastric
What location in the stomach is the bx for H. pylori taken?
antrum
List the locations of gastric ulcers types I–V
Type I – lesser curve along body of stomach
Type II – 2 ulcers, lesser curve and duodenal
Type III – prepyloric
Type IV – lesser curve high along cardia of stomach
Type V – associated with NSAIDs
What is the timing after event for stress gastritis?
3–10 days after event
Chronic gastritis has types A and B what is their location and what are they associated with?
Type A (fundus) – associated with pernicious anemia, autoimmune disease
Type B (antral) – associated with H. pylori
Where are 40% of gastric cancers located?
antrum
What is the difference in the pain with gastric cancer vs gastric ulcer?
gastric ulcer pain is relived by eating but recurs 30 min later.
What blood type is a risk factor for gastric cancer?
type A
What is Krukenberg tumor?
gastric cancer with mets to ovaries
What is Virchow's nodes?
gastric cancer with metastases to supraclavicular nodes
What size margins in subtotal gastrectomy for gastric cancer?
5 cm
What is diffuse gastric cancer called?
linitis plastica
What is the surgical tx for linitis plastica?
total gastrectomy
In palliation for gastric cancer, proximal obstruction can be treated with what? and distal?
proximal can be stented, distal lesions can be bypassed with gastrojejunostomy
What is the most common benign gastric neoplasm? aka?
gastric leiomyomas, also called gist tumors
What is the chemotherapy agent and MOA for gastric leiomyomas?
Gleevec (tyrosine kinase inhibitor)
What is the proto–oncogene are most gastric leiomyomas positive for?
c–kit (CD117)
What route does gastric leiomyosarcoma spread?
hematogenous
What is the tx for mucosa associated lymphoid tissue lymphoma (MALT lymphoma)? and if it does not regress?
Triple therapy abx for H. pylori; CHOP
What are the surgical eligibility criteria for bariatric surgery?
BMI >40 kg or BMI >35 kg with coexisting comorbiditiies
What is the medical and surgical tx for dumping syndrome?
octreotide may be effective. Surgery is rarely needed but includes converting a billroth I or II to a roux–en–Y gastrojejunostomy. Or increasing the gastric reserve with a jejunal pouch or increasing emptying type with a reversed jejunal loop
What is the dietary tx for dumping syndrome?
small, low–fat, low–carb, increased–protein meals; no liquids with meals; no lying down after meals
What are two surgical options for treating dumping syndrome after gastrectomy?
conversion of billroth I or billroth II to Roux–en–Y gastrojejunostomy

Operations to increase gastric reservoir (jejunal pouch) or increase emptying time (reversed jejunal loop)
After a gastrectomy there is postprandial epigastric pain associated with N/V; pain not relived with vomiting. Evidence of bile reflux into stomach and histologic evidence of gastritis. Dx?
Alkaline reflux gastritis
What are 3 medical options for the tx of alkaline reflux gastritis after gastrectomy?
H2 blockers, cholestyramine, metoclopramide
What is the surgical option for treating alkaline reflux gastritis after gastrectomy?
Conversion of Billroth I or Billroth II to Roux–en–Y gastrojejunostomy with afferent limb 60 cm distal to original gastrojejunostomy
In roux–en–y which limb is the roux limb? Which is the afferent limb?
The roux limb goes from the gastrojejunostomy to the jejunojenuostomy. The afferent limb is the portion of duodenum and jejunum feeding the jejunojenunostomy.
What is the cause of roux stasis?
stasis of chyme in Roux limb due to loss of jejunal motility.
How do you dx Roux stasis?
EGD, emptying studies
What are 2 treatment options for Roux stasis?
metoclopramide/prokinetics

shorten Roux limb to 40 cm
What is caused by delayed gastric emptying after vagotomy?
chronic gastric atony
What is the surgical treatment for chronic gastric atony after gastrecomy?
near total gastrectomy with Roux–en–Y
What is the surgical option for small gastric remnant and early satiety after gastrectomy?
jejunal pouch reconstruction
After Billroth II or Roux–en–Y, symptoms include pain, diarrhea, malabsorption, B12 deficiency, steatorrhea. Caused by bacterial overgrowth and stasis in affarent limb.
Blind–loop syndrome
What is the medical and surgical treatment options for blind–loop syndrome?
tetracycline, Flagyl, metoclopramide

reanastomosis with shorter (40 cm) afferent limb

zenker's diverticulus true diverticulum?

no, false diverticulum

traction diverticulum true diverticulum?

yes, true diverticulum

pharyngoesophageal disorders, solids or liquids worse?

liquids

tx for zenkers

Tx: cricopharyngeal myotomy (key point); Zenker’s itself can either be resected or suspended (removal of diverticula is not necessary)


Left cervical incision; leave drains in;


esophagogram POD #1

posterior or lateral?


zenkers and traction divertiuclum

zenkers posterior


traction lateral

tx of traction diverticulum

sx? excision and close


asx? nothing.

Epiphrenic diverticulum Rare; associated with

esophageal motility disorders(eg achalasia)

Tx: Epiphrenic diverticulum

Tx: diverticulectomy and esophageal myotomy on the side opposite the diverticulectomy if symptomatic

ACHALASIA cause

Caused by lack of peristalsis and failure of LES to relaxafter food bolus

ACHALASIA pathophys

Secondary to autoimmune destruction of neuronal ganglion cells in muscle wall

imaging of ACHALASIA

Can get tortuous dilated esophagus and epiphrenic diverticula; bird’s beak appearance

if dilation and medication fail in ACHALASIA

Heller myotomy (left thoracotomy, myotomy of lower esophagus only; also need partial Nissen fundoplication)

can get what cancer in achalasia

Can get esophageal CA late (squamous cell most common)

infection that can cause achalasia

T. cruzi can produce similar symptoms

medical tx for DIFFUSE ESOPHAGEAL SPASM

: calcium channel blocker, trazodone;

if meds fail for DIFFUSE ESOPHAGEAL SPASM

Heller myotomy if those fail (myotomy of upper and lower esophagus; right thoracotomy)

what is dx of CHEST pain +/- dysphagia

NUTCRACKER ESOPHAGUS

manometry of NUTCRACKER ESOPHAGUS

high-amplitude peristaltic contractions (> 180 mm Hg);




LES ok

tx of NUTCRACKER ESOPHAGUS

same as diffuse esophageal spasm




calcium channel blocker, trazodone; Heller myotomy if those fail (myotomy of upper and lower esophagus; right thoracotomy)

sx of scleroderma esophagus

Heartburn, massive reflux, dysphagia

how is LES tone?




reflux?

loss of LES tone


massive refluxand strictures

tx SCLERODERMA

Tx: PPI and Reglan; esophagectomy usual if severe

dx GERD?

Dx: pH probe (best test), endoscopy, histology, manometry

(resting LES in GERD?

(resting LES < 6 mm Hg)

GERD


Key maneuver for dissection is __


Key maneuver for wrap is__

Key maneuver for dissection is finding the right crura


Key maneuver for wrap is identification of the left crura

sx of Type II –HIATAL HERNIA

Symptoms: chest pain, dysphagia, early satiety

best way to dx schatzki's ring

what to do if have dysphagia after nissen

wrap too tight




(generally resolves on its own;


give clears for 1st week;


can dilate after 1 week)

pt with chest pain, retching without vomiting, can’t pass NG tube;




what is it? what to do

paraesophageal hernia II-IV..


risk for incarceration


usually need repair


may want to avoid repair in the elderly and frail if minimal symptoms

adenoca of esophagus met to where?

liver mc

SCC of esophagus met to where?

lung mc

Most important prognostic factor in patient devoid of systemic metastases

nodal spread

primary blood supply to stomach after replacing esophagus in ca resection

Right gastroepiploic artery




(have to divide left gastric and short gastrics)

to resect esophageal ca- can use what approaches

Transhiatal approach-cervical anastomosis (mortality from esophageal leaks)




Ivor Lewis – intrathoracic anastomosis




3-Hole esophagectomy - abdominal, thoracic, and cervical incisions

need to als perform __ in these 3 procedures

pyloromyotomy

when to Thoracic duct ligation




where at?

> 2 L/day or is refractory to medical Tx




right side, low in the mediastinum)

Post-op chemo? (indicated for node-positive disease)

cisplatin and 5FU

complication of esophageal ca resection-- die w/i 3 mo

Malignant fistulas


Tx – esophageal stent for palliation

After esophagectomy how to r/o leak

→ need contrast study on postop day 7 to rule out leak

Esophagectomy margins

Need 6–8 cm margins

ESOPHAGEAL POLYPS Symptoms

dysphagia, hematemesis

2nd most common benign tumor of the esophagus




where aT?

ESOPHAGEAL POLYPS


cervical esophagus

alkali ingestion- ____necrosis


acid ingestion- ___ necrosis

deep liquefaction necrosis


coagulation necrosis;

Degree of injury:Primary burn looks like


tx?

hyperemia




Conservative Tx: IVFs, spitting, antibiotics, oral intake after 3–4 days; may need future serial dilation for strictures (usually cervical)

Degree of injury: secondary burn looks like




tx?

ulcerations, exudates, and sloughing




Tx: prolonged observation and conservative therapy as above; TPN




Indications for esophagectomy – sepsis, peritonitis, mediastinitis, free air, mediastinal or stomach wall air, crepitance, contrast extravasation, pneumothorax, large effusion

Degree of injury: Tertiary burn looks like




tx?

deep ulcers, charring, and lumen narrowing




Tx: as above; esophagectomy usually necessary

Degree of injury:Primary burn complication...

Can also get shortening of esophagus with GERD (Tx: PPI)

Caustic esophageal perforations are repaired?

NO- esophageal perforations require esophagectomy (are not repaired due to extensive damage)

tx for if esophageal perf not contained


< 24 hours or minimal contamination :



primary repair with drains


Need longitudinal myotomy to see the full extent of injury

tx for if esophageal perf not contained


>48 or extensive contamination :

Neck – just place drains (no esophagectomy) → will eventually heal




Chest – 1) resection (esophagectomy, cervical esophagostomy) or


2) exclusion and diversion (cervical esophagostomy, staple across distal esophagus, washout mediastinum, place chest tubes – late esophagectomy at time of gastric replacement)




Gastric replacement of esophagus late when patient fully recovers