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12 Cards in this Set
- Front
- Back
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Leuprolide?
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GnRH analog (agonist)
use pulsatile or continuous for -infertility - pulsatile prostate cancer - continuous (w/flutamide - antiandrogen) -uterine fibroids - continuous can cause antiandrogen, nausea, & vomiting |
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Testosterone?
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methyltestosterone
tx hypogonadism & promote development of 2nd sex characteristics stimulate anabolism to promote recovery after BURN or injury tx ER positive breast cancer (exemestane) can cause premature closure of epiphyseal plates |
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antiandrogens?
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Finasteride - 5-alpha reductase inhibitor
-use for BPH, male pattern baldness Flutamide - nonsteroidal competitive inhibitor of androgens at testosterone receptor -use for tx prostate carcinoma Ketoconazole - inhibit steroid synthesis (inhibit desmolase) Spironolactone - inhibit steroid binding |
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estrogens?
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ethinyl estradiol
DES mestranol hypogonadism or ovarian failure menstrual abnlities HRT in postmenopasual men w/androgen dependent prostate cancer |
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Clomiphene?
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partial agonist at estrogen receptors in hypothalamus
preent nl feedback inhibition, increasing LH & FSH release to stimulate ovulation tx infertility in PCOS may cause multiple simulataneous pregnancies, visual disturbances |
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Raloxifene? Tamoxifen?
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selective estrogen receptor modulators
Raloxifene - agonist on bone; -tx osteoperosis Tamoxifen - antagonist on breast; -tx & prevent recurrence of ER pos breast cancer |
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Exemestane? Anastrazole?
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aromatase inhibitors
postmenopausal women w/breast cancer |
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Mifepristone?
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RU-486
competitive inhibitor of progestins at progesterone receptors TERMINATION OF PREGNANCY (adminstered w/misoprostal (PGE1)) causes heavy bleeding, GI effects, abdominal pain |
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Ritodrine? terbutiline?
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beta-2 agonists
relax uterus reduce premature uterine contractions Ritodrine - fetus "returns to dreams" |
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Tamsulosin?
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alpha-1 antagonist
tx BPH by inhibiting smooth mm contraction selective for alpha-1 A,D (on prostate) vs vascular alpha -1 B receptors |
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Danazol?
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synthetic androgen - partial agonist at androgen receptors
use for endometriosis hereditary angioedema can cause weight gain, edema, acne, hirsutism, masculinization, decreased HDL |
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Vardenafil? Sildenafil?
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inhibit cGMP phosphodiesterase
erection (corpus cavernosum) |
