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29 Cards in this Set
- Front
- Back
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Indication:
Postmenopausal women with breast cancer (used to decrease [estrogen]) Rx? |
Anastrozole
Exemestane (aromatase inhibitors) |
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Indication:
Reduce premature uterine contractions Rx? |
Terbutaline, Ritodrine
(Beta-2 agonists) |
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Indication:
Induce labor by causing cervical dilatation and uterine contraction Rx? |
Dinoprostone
(PGE2 analog) |
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Indication:
Endometrial cancer treatment Rx? |
Progestin
(binds progesterone receptors) |
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Indication:
Used to treat abnormal uterine bleeding Rx? |
Progestin
(binds progesterone receptors) |
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Indication:
Infertility Rx? |
Clomiphene
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Indication:
PCOS Rx? |
Clomiphene
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Clomiphene MOA
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partial agonist at estrogen receptors in hypothalamus. prevents feedback inhibition and thus increases LH and FSH --> stimulates ovulation
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Clomiphene Toxicity?
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hot flashes, ovarian enlargement, visual disturbances, multiple simultaneous pregnancies
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Treatment and prevention of recurrence in ER-positive breast cancer?
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Tamoxifen
(also protects against osteoporosis) |
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Tx for osteoporosis?
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Raloxifene
(agonist on bone) |
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Indication:
Burn victim. Rx to increase anabolism? |
Testosterone (methyltestosterone)
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Treatment of ER positive breast cancer? (2)
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Testosterone and Tamoxifen
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Side effects of Testosterone in males?
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reduces intratesticular testosterone in males by inhibiting Leydig cells, leads to gonadal atrophy.
Premature closure of epiphyseal plates. increase LDL, decrease HDL |
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Malignancies encouraged by Estrogen
(3) |
Increase risk of endometrial cancer
clear cell adenocarcinoma in female exposed to DES in utero USE AS Rx IS CONTRAINDICATED IN ER-POSITIVE BREAT CANCER |
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Indication:
Male with BPH(yperplasia!) Difficulty with urination Rx? |
Prazosin
(alpha-1 blocker) |
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Target of nerve block in pregnancy?
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Pudendal nerve
(use ischial spine as bony landmark) |
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Indication:
Ovarian failure Rx? |
Estrogen
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Indication:
Unwanted pregnancy Rx? |
Mifepristone (RU-486)
given with misoprostol |
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Mifepristone (RU-486) MOA
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competitive inhibitor of progestins at progesterone receptors.
(termination of pregnancy) |
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Rx for infertility? (2)
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Clomiphene and Leuprolide (administered in pulsatile fashion)
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Indication:
Uterine fibroids Rx? |
Leuprolide (continuous)
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Indication:
Prostate Cancer Rx? (2) |
Leuprolide (continuous) administered with flutamide
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Lauprolide MOA
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GnRH analog with agonist properties when used in pulsatile fashion, and antagonist properties when used continuously.
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Flutamide MOA
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nonsteriodal competitive inhibitor of androgens at the testosterone receptor
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Indication:
PCOS with hirsutism Rx to treat hirsutism? (2) |
Ketoconazole (inhibits steroid synthesis)
and Spironolactone (inhibits steroid binding) |
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Useful in BPH?
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Finasteride
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Finasteride MOA
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5-alpha-reductase inhibitor
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Tx male pattern baldness?
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Finasteride
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