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62 Cards in this Set

  • Front
  • Back
Which type of inhibitors affect Km?
Competitive
Which type of inhibitors decrease Vmax?
Noncompetitive
Which Type of inhibitors decrease potency?
Competitive
Which Type of inhibitors decrease efficacy?
Non-competitive
Which type of inhibitors are overcome by increased [S]?
Competitive
Do large, charged molecules have a high or low Vd?
low
What is Ke?
Elimination constant
How many half-lifes to reach 95% concentration?
4-5
What is the equation for Loading dose? Maintenance dose?
Loading = Cp x Vd/F

Maintenance = Cp x CL/F
Which dosing is affected by liver or renal dz?
Maintenance dose decreases in renal/liver dz
How would you treat amphetamine overdose by changing urine ph?
Give acid (ammonium chloride)
How would you treat aspirin overdose by changing urine ph?
Give bicarb
Which phase of metabolism is lost by geriatric pts?
Phase I
What is the G-protein class of alpha1 receptors?
q
What is the G-protein class of alpha2 receptors?
i
What is the G-protein class of beta1 receptors?
s
What is the G-protein class of beta2 receptors?
s
What is the G-protein class of M1 receptors?
q
What is the G-protein class of M2 receptors?
i
What is the G-protein class of M3 receptors?
q
What is the G-protein class of D1 receptors?
s
What is the G-protein class of D2 receptors?
i
What is the G-protein class of H1 receptors?
q
What is the G-protein class of H2 receptors?
s
What is the G-protein class of V1 receptors?
q
What is the G-protein class of V2 receptors?
s
Which G protein linked receptors function to increase vascular smooth m. contraction, increase pupillary dilator m. contraction and increase intestinal/bladder sphincter m. contraction?
alpha 1
Which G protein linked receptors function to decrease sympathetic outflow and insulin release?
alpha 2
Which receptors act on Phospholipase C?
Gq --> H1, alpha1, V1, M1, M3
Which receptors inhibit adenylyl cyclase?
Gi --> M2, alpha2, D2
Which G protein linked receptors function to increase HR, contractility, renin release, and lipolysis?
beta-1
Which G protein linked receptors function to increase vasodilation, bronchodilation, HR, contractility, lipolysis, insulin release and decrease uterine tone?
beta-2
Which G protein linked receptors function on the CNS and enterics?
M1
Which G protein linked receptors function to decrease HR and contractility of atria?
M2
Which G protein linked receptors function to increase exocrine gland secretions, increase gut peristalsis, increase bladder contraction, bronchocontriction, increase pupillary sphincter muscle contraction, and increase ciliary muscle contraction
M3
Which G protein linked receptors function to relax renal vascular smooth m.?
D1
Which G protein linked receptors function to modulate transmitter release in the brain?
D2
Which G protein linked receptors function to increase nasal and bronchial mucus production, contraction of bronchioles, pruritis and pain
H1
Which G protein linked receptors function to increase gastric acid secretion?
H2
Which G protein linked receptors function to increase vascular smooth muscle contraction only?
V1
Which G protein linked receptors function to increase water permeability and reabsorption in the collecting tubules of the kidney
V2
What are the symptoms of organophosphate poisoning?
DUMBBELSS

Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscle and CNS, Lacrimation, Sweating and Salivation
Which cholinomimetics are used to treat glaucoma?
Carbachol, Physostigmine and Echothiophate
Which cholinomimetics are used for post-op ileus?
Bethanechol, Neostigmine
Which M blocker is used for Parkinson's
Benztropine
Which M blocker is used for asthma?
Ipratropium bromide
Name the three main alpha 1 blockers
Prazosin, terazosin, doxazosin
What are the nonselective beta blockers?
"Please Try Not being Picky"

Pindolol, Timolol, Nadolol, Propranolol
What's the Rx for beta blocker OD?
glucagon
What's the Rx for copper, arsenic, gold poisoning?
penicillamine
What's the Rx for TCA OD?
Bicarb the urine
What's the Rx for Theophylline OD?
Beta blocker
What are the main two ABX that cause pseudo colitis?
clidamycin and ampicillin
What are the four main drugs that cause SLE like syndrome?
HIPP - Hydralazine, INH, Procainamide, Phenytoin
What drug is known to cause Fanconi's syndrome?
expired tetracycline
Which two drugs are known to cause cinchonism?
Quinidine, quinine
Which three main drugs cause parkinsonism?
Anti-psychotics, reserpine, metoclopramide
What are the three main drugs that cause seizures?
Buproprion, imipenem, INH
Which class of drugs can cause tardive dyskinesia?
Antipsychotics
What side effect is shared by AGs, vancomycin, loop diuretics and cisplatin?
Nephrotoxicity/ototoxicity
What are the 8 main P-450 inducers?
"Queen Barb Steals Phen-phen and Refuses Greasy Carbs Chronically"

Qunidine, Barbiturates, St. Johns, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, Chronic EtOH
What are the 10 main P450 inhibitors?
MAGICRACKS

Macrolides, Amiodarone, Grapefruit, INH, Cimetidine, Ritonavir, Acute EtOH, Ciprofloxacin, Ketoconazole, Sulfas