Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
62 Cards in this Set
- Front
- Back
|
Which type of inhibitors affect Km?
|
Competitive
|
|
|
Which type of inhibitors decrease Vmax?
|
Noncompetitive
|
|
|
Which Type of inhibitors decrease potency?
|
Competitive
|
|
|
Which Type of inhibitors decrease efficacy?
|
Non-competitive
|
|
|
Which type of inhibitors are overcome by increased [S]?
|
Competitive
|
|
|
Do large, charged molecules have a high or low Vd?
|
low
|
|
|
What is Ke?
|
Elimination constant
|
|
|
How many half-lifes to reach 95% concentration?
|
4-5
|
|
|
What is the equation for Loading dose? Maintenance dose?
|
Loading = Cp x Vd/F
Maintenance = Cp x CL/F |
|
|
Which dosing is affected by liver or renal dz?
|
Maintenance dose decreases in renal/liver dz
|
|
|
How would you treat amphetamine overdose by changing urine ph?
|
Give acid (ammonium chloride)
|
|
|
How would you treat aspirin overdose by changing urine ph?
|
Give bicarb
|
|
|
Which phase of metabolism is lost by geriatric pts?
|
Phase I
|
|
|
What is the G-protein class of alpha1 receptors?
|
q
|
|
|
What is the G-protein class of alpha2 receptors?
|
i
|
|
|
What is the G-protein class of beta1 receptors?
|
s
|
|
|
What is the G-protein class of beta2 receptors?
|
s
|
|
|
What is the G-protein class of M1 receptors?
|
q
|
|
|
What is the G-protein class of M2 receptors?
|
i
|
|
|
What is the G-protein class of M3 receptors?
|
q
|
|
|
What is the G-protein class of D1 receptors?
|
s
|
|
|
What is the G-protein class of D2 receptors?
|
i
|
|
|
What is the G-protein class of H1 receptors?
|
q
|
|
|
What is the G-protein class of H2 receptors?
|
s
|
|
|
What is the G-protein class of V1 receptors?
|
q
|
|
|
What is the G-protein class of V2 receptors?
|
s
|
|
|
Which G protein linked receptors function to increase vascular smooth m. contraction, increase pupillary dilator m. contraction and increase intestinal/bladder sphincter m. contraction?
|
alpha 1
|
|
|
Which G protein linked receptors function to decrease sympathetic outflow and insulin release?
|
alpha 2
|
|
|
Which receptors act on Phospholipase C?
|
Gq --> H1, alpha1, V1, M1, M3
|
|
|
Which receptors inhibit adenylyl cyclase?
|
Gi --> M2, alpha2, D2
|
|
|
Which G protein linked receptors function to increase HR, contractility, renin release, and lipolysis?
|
beta-1
|
|
|
Which G protein linked receptors function to increase vasodilation, bronchodilation, HR, contractility, lipolysis, insulin release and decrease uterine tone?
|
beta-2
|
|
|
Which G protein linked receptors function on the CNS and enterics?
|
M1
|
|
|
Which G protein linked receptors function to decrease HR and contractility of atria?
|
M2
|
|
|
Which G protein linked receptors function to increase exocrine gland secretions, increase gut peristalsis, increase bladder contraction, bronchocontriction, increase pupillary sphincter muscle contraction, and increase ciliary muscle contraction
|
M3
|
|
|
Which G protein linked receptors function to relax renal vascular smooth m.?
|
D1
|
|
|
Which G protein linked receptors function to modulate transmitter release in the brain?
|
D2
|
|
|
Which G protein linked receptors function to increase nasal and bronchial mucus production, contraction of bronchioles, pruritis and pain
|
H1
|
|
|
Which G protein linked receptors function to increase gastric acid secretion?
|
H2
|
|
|
Which G protein linked receptors function to increase vascular smooth muscle contraction only?
|
V1
|
|
|
Which G protein linked receptors function to increase water permeability and reabsorption in the collecting tubules of the kidney
|
V2
|
|
|
What are the symptoms of organophosphate poisoning?
|
DUMBBELSS
Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscle and CNS, Lacrimation, Sweating and Salivation |
|
|
Which cholinomimetics are used to treat glaucoma?
|
Carbachol, Physostigmine and Echothiophate
|
|
|
Which cholinomimetics are used for post-op ileus?
|
Bethanechol, Neostigmine
|
|
|
Which M blocker is used for Parkinson's
|
Benztropine
|
|
|
Which M blocker is used for asthma?
|
Ipratropium bromide
|
|
|
Name the three main alpha 1 blockers
|
Prazosin, terazosin, doxazosin
|
|
|
What are the nonselective beta blockers?
|
"Please Try Not being Picky"
Pindolol, Timolol, Nadolol, Propranolol |
|
|
What's the Rx for beta blocker OD?
|
glucagon
|
|
|
What's the Rx for copper, arsenic, gold poisoning?
|
penicillamine
|
|
|
What's the Rx for TCA OD?
|
Bicarb the urine
|
|
|
What's the Rx for Theophylline OD?
|
Beta blocker
|
|
|
What are the main two ABX that cause pseudo colitis?
|
clidamycin and ampicillin
|
|
|
What are the four main drugs that cause SLE like syndrome?
|
HIPP - Hydralazine, INH, Procainamide, Phenytoin
|
|
|
What drug is known to cause Fanconi's syndrome?
|
expired tetracycline
|
|
|
Which two drugs are known to cause cinchonism?
|
Quinidine, quinine
|
|
|
Which three main drugs cause parkinsonism?
|
Anti-psychotics, reserpine, metoclopramide
|
|
|
What are the three main drugs that cause seizures?
|
Buproprion, imipenem, INH
|
|
|
Which class of drugs can cause tardive dyskinesia?
|
Antipsychotics
|
|
|
What side effect is shared by AGs, vancomycin, loop diuretics and cisplatin?
|
Nephrotoxicity/ototoxicity
|
|
|
What are the 8 main P-450 inducers?
|
"Queen Barb Steals Phen-phen and Refuses Greasy Carbs Chronically"
Qunidine, Barbiturates, St. Johns, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, Chronic EtOH |
|
|
What are the 10 main P450 inhibitors?
|
MAGICRACKS
Macrolides, Amiodarone, Grapefruit, INH, Cimetidine, Ritonavir, Acute EtOH, Ciprofloxacin, Ketoconazole, Sulfas |
