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18 Cards in this Set

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  • Back
  • 3rd side (hint)
What are the clinical uses of the H1 blockers?
allergy, motion sickness, sleep aid
Name the H1 blockers. (3 1st generation and 3 2nd generation).
1st = diphenhydramine, dimenhydrinate, chlorpheniramine. 2nd = loratadine, fexofenadine, desloratadine
The side effects of H1 blockers?
sedation, animuscarinic, anti-alpha-adrenergic. 2nd gen far less sedating.
What classes of drugs are used to treat asthma?
B-agonists, B2-agonists, methylxanthines, muscarinic antagonists, cromolyn, corticosteroids, antileukotrienes
Name the nonspecific B-agonist that causes bronchial smooth muscle relaxation and tachycardia.
Name the B2 agonist used during acute asthma exacerbations.
What is Salmeterol used for?
long-acting B2-agonist used for prophylaxis
What is the MOA of Theophylline (a methylxanthine)?
causes bronchodilation by inhibiting phosphodiesterase and decreasing cAMP hydrolysis.
Adverse effects of Theophylline?
Narrow therapeautic index! Limited use! Cardiotoxicity and neurotoxicity
Which class of drugs does Ipratropium belong to?
Muscarinic antagonists
What is the MOA of Cromolyn and what is its clinical use?
prevents degranulation of mast cells; therefore only effective for prophylaxis and not during and asthma attack.
What is 1st line therapy for chronic asthma?
corticosteroids (beclomethasone and prednisone)
What is the MOA of beclomethasone?
inhibit cytokine synthesis. Inactivate NF-kappaB, the tf that induces TNF-alpha
What is the MOA of Zileuton?
5-lipoxygenase pathway inhibitor that blocks conversion of arachidonic acid to leukotrienes
What are Zafirlukast and montelukast especially good at treating? (MOA?)
aspirin-induced asthma; b/c they block leukotriene receptors
Do expectorants (Guaifenesin) suppress the cough reflex?
No, they only remove excess sputum
What is N-acetylcystine?
a mucolytic that can loosen mucus plugs in CF patients