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33 Cards in this Set

  • Front
  • Back
Name 4 antipsychotics (neuroleptics).
thioridazine, haloperidol, fluphenazine, chlorpromazine
What is the MOS of antipsychotics?
block dopamine D2 receptors
Drug class used to treat excess dopamine connected with schizophrenia?
Adverse effects of antipsychotics?
extrapyramidal symptoms, gynacomastia, dry mouth, constipation, hypotension, sedation. Important: neuroleptic malignant syndrome and tardive dyskinesia!
Symptoms of neuroleptic malignant syndrome?
rigidity, myoglobinuria, autonomic instability, hyperpyrexia
How do you treat neuroleptic malignant syndrom?
dantrolene and dopamine agonists
What are EPS side effects?
acute dystonia, akinesia, akathisia, tardive dyskinesia (often irreversible)
Name 3 atypical antipsychotics.
clozapine, olanzapine, riserperidone
MOA of clozapine?
blocks 5-HT2 and dopamine receptors
Clinical use of olanzapine?
schizo positive and neg. symptoms, OCD, anxiety disorder, depression, mania, tourettes
Side effects of atypical antipsychotics?
fewer EPS and fewer anticholinergic side effects than typical antipsychotics. Clozapine may cause agranulocytosis.
Clinical use of lithium?
mood stabilizer for bipolar affective disorder; blocks relapse and acute mania events
Side effects of lithium?
tremor, hypothyroidism, nephrogenic diabetes insipidus, teratogenesis. Narrow therapeautic window!!
Buspirone MOA?
stimulates 5-HT1a receptors
Buspirone clinical use?
generalized anxiety disorder
Name the 4 main classes of antidepressants.
SSRIs, TCAs, Heterocyclic antidepressants, MAOIs
Name 4 SSRIs.
fluoxetine, sertraline, paroxetine, citalopram
Toxicity of SSRIs?
fewer side effects than TCAs. GI distress, sexual dysfunction, "serotonin syndrome" if used with MAOIs (= hyperthermia, muscle rigidity, CV collapse)
Do antidepressants work immediately?
No, usually takes 2-3 weeks
What drug class do the following belong to: imipramine, amitriptyline, desipramine, nortriptyline, clomipramine, doxepin?
How do TCAs work?
block reuptake of NE and serotonin
Which TCAs have more anticholinergic side effects?
tertiary TCAs (amitriptyline) have more than secondary TCAs (nortriptyline)
What are the major toxixities associated with TCAs?
"Tri-C's" = Convulsions, Coma, Cardiotoxicity (arrhythmias). Also resp. depression and hyperpyrexia (extremely high fever)
Name the 5 heterocyclic antidepressants.
Bupropion, Venlafaxine, Mirtazapine, Maprotiline, Trazodone
Which antidepressant is also used for smoking cessation?
MOA of Venlafaxine?
inhibits serotonin, NE, and dopamine reuptake
MOA of Mirtazapine?
alpha-2 antagonist (increases release of NE and serotonin), 5-HTs and 5-HT3 receptor antagonist
MOA of Maprotiline?
blocks NE reuptake
MOA of trazodone?
inhibits serotonin reuptake
Name 2 MAOIs
phenelzine, tranylcypromine
Clinical use of MAOIs?
atypical depression with psychotic or phobic features, anxiety, hypochondriasis
Important toxicity of MAOIs?
Hypertensive crisis with tyramine ingestion (red wine, cheese, fava beans) and meperidine.