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107 Cards in this Set

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Antidote to acetaminophen?
N-acetylcysteine
Antidote to Salicylates?
alkalinize urine, dialysis
Antidote to anticholinesterases, organophosphates?
atropine, pralidoxime
Antidote to antimuscarinic, anticholinergic agents?
physostigmine salicylate
Antidote to beta blockers?
glucagon
Antidote to digitalis?
stop dig, normalize K+, lidocaine, anti-dig Fab fragments, Mg++
Antidote to Iron?
deferoxamine
Antidote to Lead?
CaEDTA, dimercaprol, succimer, penicillamine
Antidote to arsenic, mercury, gold?
dimercaprol (BAL), succimer
Antidote to copper, arsenic, gold?
penicillamine
Antidote to cyanide?
nitrite, hydroxocobalamin, thiosulfate
Antidote to methemoglobin?
methylene blue
Antidote to CO?
100% O2, hyperbaric O2
Antidote to methanol, ethylene glycol?
ethanol, dialysis, fomepizole
Antidote to opioids?
naloxone/naltrexone
Antidote to Benzos?
flumazenil
Antidote to TCAs?
NaHCO3 (nonspecific)
Antidote to heparin?
protamine
Antidote to warfarin?
Vit K, fresh frozen plasma
Antidote to tPA, streptokinase?
aminocaproic acid
Effects and tx of Lead poisoning?
LEAD (LeadLines on gingiva and long bones, Encephalopathy and Erythrocyte basophilic stippling, Abdominal colic and sideroblastic microcytic Anemia, wrist and foot Drop. Dimercaptol and EDTA 1st line treatment. Succimer for kids…it sucks to be a kid w/lead poisoning)
How do you increase clearance of phenobarb, MTX, aspirin?
these are weak acids. Give Bicarb to alkalinize urine and increase clearance
How do you increase clearance of amphetamines?
weak bases. Give NH4Cl to acidify urine and increase clearance
Which drugs causes atropine-like side effects?
TCAs
Which drugs cause cardiac toxicity?
doxorubicin, daunorubicin
Which drug causes coronary spasm?
cocaine
which drugs cause cutaneous flushing?
niacin, CCBs, adenosine, vancomycin
Which drug causes torsades?
Class III (sotalol), Class IA (quinidine), cisapride
Which drugs cause agranulocytosis?
clozapine, carbamazepine, colchicine
Which drugs cause aplastic anemia?
Chloramphenicol, benzene, NSAIDs
Which drug causes grey baby syndrome?
chloramphenicol
Which drugs cause hemolysis in G6PD def?
sulfonamides, INH, ASA, ibuprofen, primaquine, nitrofurantoin
Which drugs cause thrombotic complications?
OCPs (estrogens, progestins)
What drugs cause cough?
ACE inhibitors (not losartan)
Which drugs cause pulmonary fibrosis?
bleomycin, amiodarone, busulfan
Which drugs cause acute cholestatic hepatitis?
macrolides
Which drugs cause focal/massive hepatic necrosis?
halothane, valproate, acetaminophen, Amanita phalloides
What drug causes hepatitis?
INH
Which drugs cause pseudomembranous colitis?
clindamycin, ampicillin
What causes adrenocortical insufficiency?
glucocorticoid withdrawal (HPA suppresion)
Which drugs can cause gynecomastia?
Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens Ketoconazole (some drugs create awesome knockers)
Which drug causes hot flashes?
tamoxifen
Which drug causes gingival hyperplasia?
phenytoin
Which drugs causes osteoporosis?
corticosteroids, heparin
Which drugs cause photosensitivity?
Sulfonamides, Amiodarone, Tetracycline ( I SAT for a photo)
Which drugs cause an SLE-like syndrome?
Hydralazine, INH, Procainaminde, Phenytoin (it's not HIPP to have lupus)
Which drugs cause tendonitis, tendon rupture and cartilage damage in kids?
fluoroquinolones
Which drug causes fanconi's syndrome?
expired tetracycline
Which drug causes interstitial nephritis?
methicillin
Which drug causes hemorrhagic cystitis?
cyclophosphamide, ifosfamide
Which drugs cause cinchonism?
quinidine, quinine
Which drugs cause DI?
Li, demeclocycline
None
Which drugs cause seizures?
Bupropion, imipenem/cilastatin
Which drugs cause tardive dyskinesia?
antipsychotics
Which drugs cause a disulfiram rxn?
metronidazole, some cephalopsorins, procarbazine, sulfonylureas
Which drugs cause nephro/neurotoxicity?
polymyxins
Which drugs cause nephro/ototoxicity?
aminoglycosides, loop diuretics, cisplatin
Which drugs are P-450 inducers?
Quinidine, Barbiturates, Phenytoin, Rifampin, Griseofulvin, Carbamazepine (Queen Barb takes Phen-phen and Refuses Greasy Carbs)
Which drugs are P-450 inhibitors?
INH, Sulfonamides, Cimetidine, Ketokonazole, Erythromycin, Grapefruit juice (Inhibitors Stop Cyber-Kids from Eating Grapefruits)
None
What is echinacea used for?
common cold
What is feverfew used for?
migraines
What is ginkgo used for?
intermittent claudication
What is kava used for?
chronic anxiety
What is Milk thistl used for?
viral hepatitis
What is saw palmetto used for?
BPH
What is St. John's wort used for?
mild/moderate depression
What is Dehydroepiandrosterone used for?
symptomatic improvement in females with SLE or AIDS
What is melatonin used for?
jet lag, insomnia
What are the toxicities of echinacea?
GI distress, dizziness, HA
What are the toxicities of ephedra?
CNS and CV stimulation; arrhytmias, CVA, SZ
What are the toxicities of feverfew?
GI, mouth uclers, antiplatelet
What are the toxicities of ginkgo?
GI, anxiety, insomnia, HA, antiplatelet
What are the toxicities of kava?
GI, sedation, ataxia, hepatotoxic, phototoxic, dermatotoxic
What are the toxicities of milk thistle?
loose stools
What are the toxicities of saw palmetto?
GI, decreased libido, HTN
What are the toxicities of St. John's wort?
GI, phototoxic, serotonin syndrome w/SSRIs; inhibits p-450
What are the toxicities of dehydroepiandrosterone?
androgenization (premenopausal), feminization (young men)
What are the toxicities of melatonin?
sedation, supresses midcycle LH, hypoprolactinemia
What category of drug has this ending: -afil?
erectile dysfunction (sildenafil)
What category of drug has this ending: -ane?
general anesthetic (halothane)
What category of drug has this ending: -azepam?
benzodiazepine (diazepam)
What category of drug has this ending: -azine?
phenothiazine (nueroleptic, antiemetic) (chlorpromazine)
What category of drug has this ending: -azole?
antifungal (ketoconazole)
What category of drug has this ending: -barbital?
barbiturate (phenobarbital)
What category of drug has this ending: -caine?
local anesthetic (lidocaine)
What category of drug has this ending: -cillin?
penicillin (methicillin)
What category of drug has this ending: -cycline?
antibiotic, protein synth inhibitor (tetracycline)
What category of drug has this ending: -ipramine?
TCA (imipramine)
What category of drug has this ending: -navir?
protease inhibitor (saquinavir)
What category of drug has this ending: -olol?
beta antagonist (propranolol)
What category of drug has this ending: -operidol?
butyrophenone (neuroleptic) (haloperidol)
What category of drug has this ending: -oxin?
cardiac glycoside (inotrope) (digoxin)
What category of drug has this ending: -phylline?
methylxanthine (tehophylline
What category of drug has this ending: -pril?
ACE inhibitor (captopril)
What category of drug has this ending: -terol?
beta 2 agonist (albuterol)
What category of drug has this ending: -tidine?
H2 antagonist (cimetidine)
What category of drug has this ending: -triptyline?
TCA (amitriptyline)
What category of drug has this ending: -tropin?
pituitary hormone (somatotropin)
What category of drug has this ending: -zosin?
alpha 1 antagonist (prazosin)
28-year old chemist presents with MPTP exposure: what NT is depleted?
dopamine
Woman taking tetracycline exhibits phototosensitivity: what are the clinical manifestations?
rash on sun exposed regions of the body
AA man who goes to africa develops a hemolytic anemia after taking malarial prophylaxis: What is the enzyme deficiency?
G6PD
Farmer presents with dyspnea, salivation, miosis, diarrhea, cramping and blurry vision: What caused this and what is the MOA?
insecticide poisoning; inhibition of ACh-esterase
None
27 yo female w/Hx of psych illness now has urinary retention due to a neuroleptic: What do you treat it with?
bethanecol
pt w/recent kidney transplant is on cyclosporine for immunosuppression. Requires antifungal agent for candidiasis: What antifungal would result in cyclosporine tox?
ketoconazole
Pt is on carbamazepine: What routine workup should always be done?
LFTs
23 yo female who is on rifampin for TB propho and on birth control (estrogen) gets pregnant. Why?
rifampin augments estrogen metabolism in the liver, redering it less effective