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107 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Antidote to acetaminophen?
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N-acetylcysteine
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Antidote to Salicylates?
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alkalinize urine, dialysis
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Antidote to anticholinesterases, organophosphates?
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atropine, pralidoxime
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Antidote to antimuscarinic, anticholinergic agents?
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physostigmine salicylate
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Antidote to beta blockers?
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glucagon
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Antidote to digitalis?
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stop dig, normalize K+, lidocaine, anti-dig Fab fragments, Mg++
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Antidote to Iron?
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deferoxamine
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Antidote to Lead?
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CaEDTA, dimercaprol, succimer, penicillamine
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Antidote to arsenic, mercury, gold?
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dimercaprol (BAL), succimer
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Antidote to copper, arsenic, gold?
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penicillamine
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Antidote to cyanide?
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nitrite, hydroxocobalamin, thiosulfate
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Antidote to methemoglobin?
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methylene blue
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Antidote to CO?
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100% O2, hyperbaric O2
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Antidote to methanol, ethylene glycol?
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ethanol, dialysis, fomepizole
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Antidote to opioids?
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naloxone/naltrexone
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Antidote to Benzos?
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flumazenil
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Antidote to TCAs?
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NaHCO3 (nonspecific)
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Antidote to heparin?
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protamine
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Antidote to warfarin?
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Vit K, fresh frozen plasma
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Antidote to tPA, streptokinase?
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aminocaproic acid
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Effects and tx of Lead poisoning?
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LEAD (LeadLines on gingiva and long bones, Encephalopathy and Erythrocyte basophilic stippling, Abdominal colic and sideroblastic microcytic Anemia, wrist and foot Drop. Dimercaptol and EDTA 1st line treatment. Succimer for kids…it sucks to be a kid w/lead poisoning)
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How do you increase clearance of phenobarb, MTX, aspirin?
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these are weak acids. Give Bicarb to alkalinize urine and increase clearance
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How do you increase clearance of amphetamines?
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weak bases. Give NH4Cl to acidify urine and increase clearance
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Which drugs causes atropine-like side effects?
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TCAs
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Which drugs cause cardiac toxicity?
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doxorubicin, daunorubicin
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Which drug causes coronary spasm?
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cocaine
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which drugs cause cutaneous flushing?
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niacin, CCBs, adenosine, vancomycin
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Which drug causes torsades?
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Class III (sotalol), Class IA (quinidine), cisapride
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Which drugs cause agranulocytosis?
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clozapine, carbamazepine, colchicine
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Which drugs cause aplastic anemia?
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Chloramphenicol, benzene, NSAIDs
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Which drug causes grey baby syndrome?
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chloramphenicol
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Which drugs cause hemolysis in G6PD def?
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sulfonamides, INH, ASA, ibuprofen, primaquine, nitrofurantoin
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Which drugs cause thrombotic complications?
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OCPs (estrogens, progestins)
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What drugs cause cough?
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ACE inhibitors (not losartan)
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Which drugs cause pulmonary fibrosis?
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bleomycin, amiodarone, busulfan
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Which drugs cause acute cholestatic hepatitis?
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macrolides
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Which drugs cause focal/massive hepatic necrosis?
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halothane, valproate, acetaminophen, Amanita phalloides
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What drug causes hepatitis?
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INH
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Which drugs cause pseudomembranous colitis?
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clindamycin, ampicillin
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What causes adrenocortical insufficiency?
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glucocorticoid withdrawal (HPA suppresion)
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Which drugs can cause gynecomastia?
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Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens Ketoconazole (some drugs create awesome knockers)
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Which drug causes hot flashes?
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tamoxifen
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Which drug causes gingival hyperplasia?
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phenytoin
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Which drugs causes osteoporosis?
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corticosteroids, heparin
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Which drugs cause photosensitivity?
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Sulfonamides, Amiodarone, Tetracycline ( I SAT for a photo)
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Which drugs cause an SLE-like syndrome?
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Hydralazine, INH, Procainaminde, Phenytoin (it's not HIPP to have lupus)
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Which drugs cause tendonitis, tendon rupture and cartilage damage in kids?
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fluoroquinolones
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Which drug causes fanconi's syndrome?
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expired tetracycline
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Which drug causes interstitial nephritis?
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methicillin
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Which drug causes hemorrhagic cystitis?
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cyclophosphamide, ifosfamide
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Which drugs cause cinchonism?
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quinidine, quinine
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Which drugs cause DI?
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Li, demeclocycline
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None
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Which drugs cause seizures?
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Bupropion, imipenem/cilastatin
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Which drugs cause tardive dyskinesia?
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antipsychotics
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Which drugs cause a disulfiram rxn?
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metronidazole, some cephalopsorins, procarbazine, sulfonylureas
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Which drugs cause nephro/neurotoxicity?
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polymyxins
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Which drugs cause nephro/ototoxicity?
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aminoglycosides, loop diuretics, cisplatin
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Which drugs are P-450 inducers?
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Quinidine, Barbiturates, Phenytoin, Rifampin, Griseofulvin, Carbamazepine (Queen Barb takes Phen-phen and Refuses Greasy Carbs)
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Which drugs are P-450 inhibitors?
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INH, Sulfonamides, Cimetidine, Ketokonazole, Erythromycin, Grapefruit juice (Inhibitors Stop Cyber-Kids from Eating Grapefruits)
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None
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What is echinacea used for?
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common cold
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What is feverfew used for?
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migraines
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What is ginkgo used for?
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intermittent claudication
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What is kava used for?
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chronic anxiety
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What is Milk thistl used for?
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viral hepatitis
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What is saw palmetto used for?
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BPH
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What is St. John's wort used for?
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mild/moderate depression
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What is Dehydroepiandrosterone used for?
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symptomatic improvement in females with SLE or AIDS
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What is melatonin used for?
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jet lag, insomnia
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What are the toxicities of echinacea?
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GI distress, dizziness, HA
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What are the toxicities of ephedra?
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CNS and CV stimulation; arrhytmias, CVA, SZ
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What are the toxicities of feverfew?
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GI, mouth uclers, antiplatelet
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What are the toxicities of ginkgo?
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GI, anxiety, insomnia, HA, antiplatelet
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What are the toxicities of kava?
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GI, sedation, ataxia, hepatotoxic, phototoxic, dermatotoxic
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What are the toxicities of milk thistle?
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loose stools
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What are the toxicities of saw palmetto?
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GI, decreased libido, HTN
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What are the toxicities of St. John's wort?
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GI, phototoxic, serotonin syndrome w/SSRIs; inhibits p-450
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What are the toxicities of dehydroepiandrosterone?
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androgenization (premenopausal), feminization (young men)
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What are the toxicities of melatonin?
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sedation, supresses midcycle LH, hypoprolactinemia
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What category of drug has this ending: -afil?
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erectile dysfunction (sildenafil)
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What category of drug has this ending: -ane?
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general anesthetic (halothane)
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What category of drug has this ending: -azepam?
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benzodiazepine (diazepam)
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What category of drug has this ending: -azine?
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phenothiazine (nueroleptic, antiemetic) (chlorpromazine)
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What category of drug has this ending: -azole?
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antifungal (ketoconazole)
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What category of drug has this ending: -barbital?
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barbiturate (phenobarbital)
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What category of drug has this ending: -caine?
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local anesthetic (lidocaine)
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What category of drug has this ending: -cillin?
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penicillin (methicillin)
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What category of drug has this ending: -cycline?
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antibiotic, protein synth inhibitor (tetracycline)
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What category of drug has this ending: -ipramine?
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TCA (imipramine)
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What category of drug has this ending: -navir?
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protease inhibitor (saquinavir)
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What category of drug has this ending: -olol?
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beta antagonist (propranolol)
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What category of drug has this ending: -operidol?
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butyrophenone (neuroleptic) (haloperidol)
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What category of drug has this ending: -oxin?
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cardiac glycoside (inotrope) (digoxin)
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What category of drug has this ending: -phylline?
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methylxanthine (tehophylline
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What category of drug has this ending: -pril?
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ACE inhibitor (captopril)
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What category of drug has this ending: -terol?
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beta 2 agonist (albuterol)
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What category of drug has this ending: -tidine?
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H2 antagonist (cimetidine)
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What category of drug has this ending: -triptyline?
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TCA (amitriptyline)
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What category of drug has this ending: -tropin?
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pituitary hormone (somatotropin)
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What category of drug has this ending: -zosin?
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alpha 1 antagonist (prazosin)
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28-year old chemist presents with MPTP exposure: what NT is depleted?
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dopamine
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Woman taking tetracycline exhibits phototosensitivity: what are the clinical manifestations?
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rash on sun exposed regions of the body
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AA man who goes to africa develops a hemolytic anemia after taking malarial prophylaxis: What is the enzyme deficiency?
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G6PD
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Farmer presents with dyspnea, salivation, miosis, diarrhea, cramping and blurry vision: What caused this and what is the MOA?
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insecticide poisoning; inhibition of ACh-esterase
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None
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27 yo female w/Hx of psych illness now has urinary retention due to a neuroleptic: What do you treat it with?
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bethanecol
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pt w/recent kidney transplant is on cyclosporine for immunosuppression. Requires antifungal agent for candidiasis: What antifungal would result in cyclosporine tox?
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ketoconazole
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Pt is on carbamazepine: What routine workup should always be done?
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LFTs
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23 yo female who is on rifampin for TB propho and on birth control (estrogen) gets pregnant. Why?
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rifampin augments estrogen metabolism in the liver, redering it less effective
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