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41 Cards in this Set

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osteoarthritis
wear-and-tear of joints -> destruction of articular cartilage, subchondral bone formation, sclerosis, osteophytes, eburnation, Herberden's nodes (DIP), Bouchard's nodes (PIP)
What is the classic presentation of osteoarthritis?
pain in weight-bearing joints after use, improving w/ rest, no systemic symptoms
rheumatoid arthritis
inflammatory disorder affecting synovial joints
What is the classic presentation of rheumatoid arthritis?
morning stiffness improving w/ use, symmetric joint involvement, systemic symptoms
Which form of arthritis presents w/ systemic symptoms? Rheumatoid arthritis or Osteoarthritis?
rheumatoid arthritis
Which form of arthritis gets better as the day progresses?
rheumatoid arthritis
Which form of arthritis improves after rest?
osteoarthritis
Which form of arthritis presents w/ pain in weight-bearing joints?
osteoarthritis
Which form of arthritis presents w/ ulnar deviation of the hand?
rheumatoid arthritis
Boutonniere deformity is a feature of what disease?
rheumatoid arthritis
Swan-neck deformity is a feature of what disease?
rheumatoid arthritis
Z-thumb deformity is a feature of what disease?
rheumatoid arthritis
Sjogren's syndrome
xerophthalmia (dry eyes, conjunctivitis)
xerostomia (dry mouth, dysphagia)
arthritis
parotid enlargement
increased risk of B-cell lymphoma
Sjogren's syndrome is associated w/ what disease?
rheumatoid arthritis
Sjogren's syndrome predominantly affects what population?
females b/w 40-60 years old
gout
precipitation of monosodium urate crystals into joints due to hyperuricemia
Which joint does gout primarily manifest?
MTP of big toe (podagra)
What is the treatment for gout?
allopurinol, probenecid, colchicine, NSAIDs
When do acute attacks of gout tend to occur?
after alcohol consumption or after a large meal
pseudogout
deposition of calcium pyrophosphate crystals w/in the joint space
Which joints does pseudogout tend to affect?
large joints (classically the knee)
What is the treatment for pseudogout?
none
celiac sprue
autoimmune-mediated intolerance of gliadin (wheat) -> steatorrhea
Celiac sprue is associated w/ people of what descent?
Northern European descent
Celiac sprue is associated w/ what disease?
dermatitis herpetiformis
What are the symptoms of systemic lupus erythematosus?
fever, fatigue, wt. loss, nonbacterial verrucous endocarditis, Raynaud's phenomenon, malar rash
Systemic lupus erythematosus causes a false positive on what test?
syphilis test (RPR/VDRL) due to antiphospholipid antibodies
Systemic lupus erythematosus is most common and severe in what population?
black females
Sarcoidosis is common in what population?
black females
What are the characteristics of sarcoidosis?
(GRAIN)
Gammaglobulinemia
Rheumatoid arthritis
ACE increase
Interstitial fibrosis
Noncaseating granulomas
ankylosing spondylitis
chronic inflammatory disease of spine and sacroiliac joints -> ankyolsis, uveitis, aortic regurgitation
Reiter's syndrome
urethritis
conjunctivitis and anterior uveitis
arthritis
scleroderma
excessive fibrosis and collagen deposition throughout the body
diffuse scleroderma
widespread skin involvement, rapid progression, early visceral involvement
associated w/ anti-Scl-70 antibody
CREST syndrome
Calcinosis
Raynaud's phenomenon
Esophageal dysmotility
Sclerodactyly
Telangiectasia
limited skin involvement (often confined to fingers and face)
associated w/ anticentromere antibody
psoriasis
nonpuritic chronic inflammation of the skin, particularly on knees and elbows
Psoriasis is associated w/ what alleles?
HLA-B27
HLA-13
HLA-17
bullous pemphigoid
autoimmune disorder w/ IgG antibody against epidermal basement membrane
similar to pemphigus vulgaris, but less severe
affects skin but spares oral mucosa
pemphigus vulgaris
potentially fatal autoimmune skin disorder
intradermal bullae involving the oral mucosa and skin
IgG antibody against epidermal cell surface
Goodpasture's syndrome
pulmonary hemorrhages -> hemoptysis
renal lesions -> hematuria, anemia, crescentic glomerulonephritis
anti-GBM antibodies -> linear staining on immunofluorescence
Goodpasture's syndrome is most common in what population?
men b/w 20-40 years old