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21 Cards in this Set
- Front
- Back
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intermediate horn?
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sympathetics
thoracic cord only |
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fasciculus cuneatus?
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upper body, extremities (lateral to gracilis)
dorsal column |
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pressure?
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dorsal column
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vibration?
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dorsal column
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touch?
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dorsal column
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proprioception?
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dorsal column
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fasciculuc gracilis?
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lower body, extremities (medial to cuneatus)
dorsal column |
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lateral corticospinal tract?
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voluntary motor
-most medial = arms -most lateral = legs |
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spinothalamic tract?
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pain & temperature
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dorsal column organization?
lateralcorticospinal tract organization? |
dorsal column is organized as you are - arms outside, legs inside
Legs are Lateral in Lateralcorticospinal tract |
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dorsal column medial lemniscus pathway
1st order neuron --> Synapse 1 --> 2nd order neuron --> Synapse 2 --> 3rd order neuron --> |
1st order neuron --> sensory nerve ending, cell body in dorsal root ganglia, ascend ipsilaterally
Synapse 1 --> ipsilateral nucleus cuneatus, gracilus (medulla) 2nd order neuron --> DECUSSATES in medulla, ascends contralaterally in medial lemniscus Synapse 2 --> VPL of thalamus 3rd order neuron --> sensory cortex |
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Spinothalamic Tract
1st order neuron --> Synapse 1 --> 2nd order neuron --> Synapse 2 --> 3rd order neuron --> |
1st order neuron --> sensory nerve ending, cell body in dorsal root ganglion, enters spinal cord
Synapse 1 --> ipsilateral gray matter (spinal cord) 2nd order neuron --> DECUSSATES at anterior white commissure, ascends contralaterally Synapse 2 --> VPL of thalamus 3rd order neuron --> sensory cortex |
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Lateral corticospinal tract
1st order neuron --> Synapse 1 --> 2nd order neuron --> Synapse 2 --> 3rd order neuron --> |
1st order neuron --> UMN, cell body in primary motor cortex, descends ipsilaterally (thru internal capsule); DECUSSATES at caudal medulla (pyramidal), descends contralaterally
Synapse 1 --> cell body of anterior horn (spinal cord) 2nd order neuron --> LMN leaves spinal cord Synapse 2 --> NMJ 3rd order neuron --> n/a |
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where does ____ decussate?
Dorsal column medial lemniscus Spinothalamic tract Lateral corticospinal tract |
Dorsal column medial lemniscus
**decussates in medulla; 2nd order neuron Spinothalamic tract **decussates at anterior white commisure ~ before ascending; 2nd order Lateral corticospinal tract **decussates at caudal medulla, UMN, descends contralaterally |
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Poliomyelitis
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destruction of cells in anterior horn of the spinal cord --> LMN destruction
CSF w/viral findings -lymphocytic pleocytosis -slight elevation protein -no change in glucose Virus recovered from stool or throat |
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Werdnig-Hoffman Dz
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infantile spinal muscular atrophy
autosomal recessive at birth - "floppy baby", tongue fasciculations -median age of death: 7 months degeneration of anterior horns, LMN inovlement only |
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Amyotrophic lateral sclerosis
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both LMN & UMN signs
no sensory, cognitive, or oculomotor deficits can be caused by defect in superoxide dismutase 1 commonly presents as fasciculations eventual atrophy, progressive, & fatal Tx: riluzole -modestly lengthen survival by decreasing presynaptic glutamate release |
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Tabes dorsalis
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degeneration of dorsal columns & dorsal roots (tertiary syphilis)
impaired proprioception & locomotor ataxia associations: -shooting "lightning" pain -argyll robertson pupils -absent DTRs -positive romberg -sensory ataxia at night - ? |
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Friedreich's ataxia
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frataxin gene has trinucleotide repeat (GAA)
autosomal recessive impaired mitochondrial function staggering gait frequent falling nystagmus, dysarthria, pes cavus, hammer toes Cause of Death --> HYPERTROPHIC CARDIOMYOPATHY Presents in childhood (5-15 years) w/kyphoscoliosis |
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Brown-sequard syndrome
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hemisection of spinal cord
below the lesion, loss of: -Ipsilateral **UMN (corticospinal tract) **Dorsal Column (prop, tactile, vibratory) -Contralateral **spinothalamic (pain, temp) at the level of lesion, loss of: -all sensation -LMN |
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which pathways decussate rostrally near medulla, & which at level of entry?
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level of entry - spinothalamic tract, in anterior white commissure
rostrally - corticospinal tract & dorsal column |
