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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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S. aureus
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1) TSST-1: superantigen, toxic shock snydrome (fever, rash, shock). 2) Enterotoxins
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S. pyogenes
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1) SPE toxin: superantigen, toxic shock-like syndrome. 2) Streptolysin O (hemolysin) => ASO antibodies
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Corynebacterium diphtheriae
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ADP-ribosylates EF2 => pharyngitis, pseudomembranes... heart, neuro
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Pseudomonas
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exotoxin ADP ribosylates EF2
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Vibrio cholera
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ADP-ribosylate Gs => * AC => inc Cl- secretion => rice water diarrhea
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E. coli
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1) Heat-labile toxin ADP-ribosylate Gs => * AC => inc Cl- secretion => watery diarrhea (like V. cholera) 2) Heat-stabile toxin * GC
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None
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Bordetella pertussis
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toxin deactivate Gi => * AC and inh chemokine R? => impaired PMN chemotaxis, lymphocytosis
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None
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Clostridium perfringes
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alpha toxin => gas gangrene. Double zone of hemolysis.
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Clostridium tetani
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enters at NMJ, retrograde transport. Degrades synaptobrevin => dec release of glycine and GABA by Renshaw cells => tetany, lockjaw
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Clostridium botulinum
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enter by endocytosis. A (light chain) cleaves SNAP25 (a SNARE) => inh ACh release => anticholinergic sx, flaccid muscle paralysis. Floppy baby syndrome. Spore in honey, canned food.
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Bacillus anthracis
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complex of exotoxins. 1 is an adenylate cyclase
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Shigella
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shiga toxin cleaves host rRNA (60S), enhances cytokine release => HUS
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None
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