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6 Cards in this Set
- Front
- Back
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Cyclosporine
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MOA:
**prevents production of IL-2 & receptor **binds cyclophilins, complex blocks diff & act of T-cells by inhibiting calcineurin Clinical Use: **suppress organ rejection Toxicity: **predispose to viral infections, lymphoma **nephrotoxic |
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Tacrolimus (FK506)
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MOA:
**inhibits secretion of IL-2 & other cytokines **binds FK-binding prtn Clinical Use: **potent immunosuppresion in organ transplant recipients Toxicity: **nephrotoxicity **peripheral neuropathy **HTN **pleural effusion **hyperglycemia |
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Sirolimus (rapomycin)
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MOA:
**inhibits T-cell proliferation in response to IL-2 **inhibits mTOR Clinical Use: **immunosuppresion after kidney transplant **drug eluting stents Toxicity: **hyperlipidemia **thrombocytopenia **leukopenia |
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Daclizumab
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MOA:
**monoclonal antibody for IL-2 receptor (on activated T-cells) |
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Azathioprine
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MOA:
**interfere w/metab & synth of nucleic acids --> toxic to proliferating T-cells **antimetabolite precursor of 6-mercaptopurine Clinical Use: **kidney transplant **autoimune disorders (ie glomneph, hemolytic anemia) Toxicity: **bone marrow suppression **toxic effects may be increased by allopurinol (mercaptopurine, active metabolite, is metabolized by xanthine oxidase) |
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Muromonab (OKT3)
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MOA:
**monoclonal antibody binding CD3 (epsilon chain) on surface of T-cells **block interaction w/CD3 prtn responsible for T-cell signal transduction Clinical Use: **immunosuppresion after kidney transplant Toxicity: **cytokine release syndrome **hypersensitivity reaction |
