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79 Cards in this Set

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Immunglobulins that bind complement
IgG, IgM
IgD
func?
IgM
1° immunne resp. complement. does not cross placenta. monomer or pentamer (J chain).
IgG
2° immune resp. complement. placenta.
IgA
mucous membranes. secretory compenent. monomer or dimer (J chain).
IgE
type I hypersensitivity, helminths, * mast/basophils, lowest []
IL-1
by Mphage. Pyrogen. Stim: T, B, PMN, fibro, endo, acute phase reactants (liver)
IL-2
by CD4+ T*. Stim: CD4+ T, CD8+ T (prolif + apop)
IL-3
by CD4+ T*. Growth + differentiation of bone marrow progenitors. ("Multi-CSF").
IL-4
by Th2. T => Th2. Stim B, isotype to igG, igE
IL-5
by Th2 and mast cells. Stim B, isotype to IgA. Stim eosinophils.
IL-6
by Th, Mphage, etc. Stim acute phase reactant prod (liver), Ig prod.
IL-8
PMN chemotaxis
IL-10
by Th2. Inh Th1 response (Mphage)
IL-12
by B, Mphage. *NK, Th1. (for intracellular pathogens)
IFN-gamma
by Th. Stim Mphage. Inc MHCI+II expression, ag presentation in all cells.
INF-alpha, beta
inhbit viral protein synthesis: induce proteins that degrade viral mRNA
TNF-alpha
by Mphage. T: IL2R synth. B: prolif. PMN: chemoattract + activate. DC: migrate to LN
Th1 cytokines
2, 12, IFN gamma
Th2 cytokines
4, 5, 10
Broadly spectrum cytokines
1, 6, TNF alpha
Th surface proteins
CD4, TCR, CD3. CD28 (=> B7). CD40L
Tc surface proteins
CD8, TCR, CD3.
B cell surface proteins
MHC II, IgM, B7, CD40. Pan B cell: CD19, CD20.
Mphage cell surface proteins
MHC II, CD14. FcR, C3bR
NK surface protoeins
MHC I, CD16, CD56
C1, C2, C3, C4
Viral neutralization
C3b
opsonization
C3a, C5a
anaphylaxis
C5a
PMN chemotaxis
C5b-9
MAC
C1 esterase inhibitor definiciency
Overactive complement, inc bradykinin => angioedema
C3 deficiency
recurrent pyogenic sinus + respiratory tract infection
C6-C9 deficiency
MAC deficiency => Neisseria bacteremia
Decay-accelerating factor deficiency
PNH. PIG-A mutation => dec CD55 (DAF), CD59, C8 binding protein. CD55 binds C3b, C4b. CD 59 binds C9.
C2 or C4 deficiencies
SLE like IC disease. complement => remove IC.
Alternative pathway C3 convertase
C3bBb
Alternative pathway C5 convertase
C3bBb3b
MBL pathway C3 convertase
C4b2b
MBL pathway C5 convertase
C4b2b3b
Classical pathway C3 convertase
C4b2b
Classical pathway C5 convertase
C4b2b3b
When give passive immunization?
To Be Healed Rapidly: Tetanus toxin, Botulinum toxin, HBV, Rabies.
Type I hypersensitivy ex
anaphylaxis/"atopy", asthma, hives, wheal/flare
Type II hypersensitivity ex
IgG, IgM => membane bound ag. Auto-immune hemolytic anemia, ITP, erythroblastosis fetalis (Rh dz), MG, Grave's dz, Bullous pemphigoid, Pemphigus vulgaris, GP, RF (connective tissue)
Type III hypersensitivity ex
arthus reaction (local vasculitis, preformed Ab), serum sickness (GN, arthritis, carditis, 5 days). PAN, SLE, RA (rheumatoid factor), IC GN
Type IV hypersensitivity ex
TB, touch (contact dermatitis), transplant rejection
Bruton's agammaglobulinemia
Boys: X linked. B cell: Btk deficiency (HC but not LC). Bacterial: S. pneumo, S. aurea, Hib. Present @ 6 mo.
DiGeorge
3rd + 4th branchial pouches fail to develop: thymic aplasia (T cell deficiency) + parathyroid gland aplasia (hypocalcemia => tetany) + cardiac, great vessel anomolies. CATCH-22: Cleft palate, abnormal facies, thymic aplasia, cardiac defects, hypocalcemia, 22q11.
SCID
Severe combined immunodeficiency. Many diff causes (MHC II, adenosine deaminase def). P/w Candida (fungal, viral, bacteral, protozoa). (mc: X-linked, gamma chain of chemokine R => T cell dysfunc => 2° B cell dysfunc.)
IL-12 R def
disseminated mycobacterium infection
Hyper IgM syndrome
CD40L defect. Dec isotype switching. Inc IgM, dec AGE. Severe pyogenic infections.
Wisckott-Aldrich syndrome
X-linked. dec M (capsular polysaccharide). inc IgA. WIPE: pyogenic Infections, thrombocytopenia Purpura, Eczema
Job's syndrome
IFN-gamma production defect. Dec Mphage func => no PMN chemotaxis. Inc IgE. Abscesses, Baby teeth, Colds, Eczema, IgE, course Facies.
Leukocyte adhesion deficiency
LFA-1 (phagocytes?). Pyogenic, fungal, *delayed separation of umbilicus*
Chediak-Higashi
MT dysfunction => phagocytosis defect => recurrent pyogenic infections. Pyogenic + Partial albinism + Peripheral neuropathy.
Chronic granulomatous disease
NADPH oxidase def => dec O2• => dec HOCl•. Dec PMN ROS => negative nitroblue tetrazolium dye reduction test
Chronic mucocutaneous candidiasis
T cell defect => chronic mucocutaneous candidiasis
Selective Ig deficiency
Prob w/ isotype switching. Usu IgA: respiratory tract infection, diarrhea, milk allergies
Ataxia-Telangiectasia
DNA repair. Ataxia (cerebellar), telangiectasia (spider angiomas). Dec IgA
ANA
SLE, not specific
Anti-dsDNA abs
specific SLE
Anti-Smith abs
specific SLE
Antihistone abs
drug-induced lupus. HIPP: hydralizine, isoniazid, procainamide, phenytoin
C-ANCA
antineutrophil. Vasculitis. Wegener's granulomatosis.
P-ANCA
antineutrophil. vasculitis. PAN
Anticentromere
Scleroderma (CREST)
Anti-Scl-70
Scleroderma (diffuse)
Anti-mitochondrial
Primary biliary cirrhosis
Anti-epithelial cell
Pemphigus vulgaris
Anti-microsomal
Hashimoto's thyroiditis
Anti-Jo-1
Polymyositis + dermatomyositis (CD8+, weakness)
B27
PAIR: Psoriasis, Ankylosing spondylitis, IBD, Reiter's syndrome
B8
Graves' dz, celiac sprue
DR2
MS, hay fever, SLE, GP "Must Suck 2 Get hay fever"
DR3
DM1
DR4
RA, DM1
DR5
Pernicious anemia, Hashimoto's thyroiditis
DR7
Steroid-responsive nephrotic syndrome