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29 Cards in this Set
- Front
- Back
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where are the B cells located in a lymph node?
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in the follicle
we're like BF's forever!!! yah!!!-----B-cell, follicle |
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where are macrophages located in a lymph node?
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in the medulla
M&M---medulla, macrophage |
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where are T cells located in lymph node?
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in the paracortex
i'm gonna TP your house---T cells, paracortex |
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what region of a lymph node is not very well developed in DiGeorge syndrome?
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the paracortex
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what node does the scrotum drain into?
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superficial inguinal
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what node do the testes drain through
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superficial and deep plexuses----para-aortic
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what nodes does the rectum drain into?
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internal iliac
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where does the rectum below the pectinate line drain lymph node wise?
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superficial inguinal
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where are T cells found in the spleen?
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in the periarterial lymphatic sheath (PALS) and in the white pulp
TP again!!! |
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where are B cells found in the spleen
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in follicles
BF's forever again!! yah!!! |
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Brutons agammaglobulinemia
defect, presentation, lab |
X-linked recessive (more in Boys) defect in Brutons Tyrosine Kinase (BTK) leads to complete lack of B cell maturation
Recurrent bacterial infections after 6 months (when breast milk IgG goes down) Normal pro-B, low mature B cells and Ig's of all classes |
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Hyper-IgM syndrome
defect, presentation, labs |
defect in the CD40L on helper T cells or CD40 receptor on B cells so that no Ig class switching occurs
recurrent pyogenic infections occur Really, really, ridiculously high IgM and low IgG, IgA, IgE |
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Selective IgA deficiency
defect, presents as, labs |
defect in isotype switching
sinus and lung infections, milk allergies, Anaphylaxis on exposure to blood products with IgA IgA deficiency MOST COMMON...low secretory IgA levels |
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Common variable immunodeficiency (CVID)
defect, presents as, labs |
defect in B-cell maturation
can be acquired in 20-30s increased risk for bacterial, enteroviral infections in LATE childhood normal number of B cells, low plasma cells |
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thymic dysplasia (DiGeorge syndrome)
defect, presents as, labs |
22q11 deletion; failure to develop 3rd and 4th pharyngeal pouches
tetany (from hypocalcemia); recurreny viral/fungal infections thymus and parathyroids dont develop so you have low T cell, low PTH, low Ca NO thymic shadow on Chest xray |
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IL-12 receptor deficiency
defect, presentation, labs |
low Th1 response
mycobacterial infections Low IFN-gamma |
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Hyper IgE syndrome (Job's syndrome)
defect, presentation, labs |
Th cell fails to produce IFN-gamma
FATED coarse Facies staph Abscesses retained primary Teeth high igE Dermatologic problems (eczema) Job was FATED for a rough time |
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severe combined immunodeficiency (SCID)
defect, presentation, labs |
could be defective cytokine receptor, adenosine deaminase (ADA) deficiency, or MHC II deficiency
recurrent viral, bacterial, fungal and protozoal infections labs: screw em bubble boy syndrome |
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whats the HY deficiency for SCID
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ADA defiency as it is necessary to deaminate adenosine and deoxyadenosine for excretion as waste products and their buildup is toxic to lymphocytes
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ataxia-telangiectasia
defect, presents as, labs |
defect in DNA repair enzymes
DAT sux see ataxia, spider angiomas, Iga deficiency labs show low IgA |
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wiskott-aldrich syndrome
defect, presents as, labs |
X-linked recessive defect leads to deletion of T and B cells
Triad of TIE: Thrombocytopenia, Infections, Eczema HIGH IgE, IgA and LOW IgM |
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leukocyte adhesion deficiency
defect, clinical |
defect in LFA-1 on phagocytes
recurrent bacterial infections, absent pus formation, delayed separation of umbilical cord |
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Chediak-Higashi syndrome
defect, clinical |
autosomal recessive defect in microtubular function with decrease in phagocytosis
see recurrent pyogenic infections by staph and strep |
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chronic granulomatous disease
defect, clinical |
lack of NADPH oxidase----LOW reactive oxygen species and ABSENT respiratory burst
increase susceptibility to catalase-positive organisms |
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muromonab targets what?
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CD3 receptor on T cells
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Daclizumab targets what?
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IL-2 receptor on T cells
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trastuzumab targets what?
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erb-B2 used for HER-2 overexpressing breast cancer
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what are some of the signs of serum sickness?
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fever, rash, polyarthralgias
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what interferon is used in the treatment of MS?
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interferon-beta
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