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13 Cards in this Set
- Front
- Back
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Hodgkin's vs Non-Hodgkins...
nodes? symptoms? age incidence? prognosis? other? |
Nodes:
-Hodgkins - localized single group, extranodal rare, contiguous spread -Non-Hodgkins - multiple, peripheral nodes, extranodal common, non-contiguous spread Symptoms: -Hodgkin's - consitutional B signs - fever, night sweat, weight loss -Non-Hodgkins - fewer constituational symptoms Age: -Hodgkins - bimodal distribution, young and old -Non-Hodgkins - peak incidence for certain subtypes at 20-40 years Prognosis: -Hodgkins - stage strongest predictor (contiguous spread); better w/increased lymphocytes, fewer RS cells -Non-Hodgkins - ? Other: -Hodgkins - mediastinal lymphadenopathy, Reed Sternberg cells, 50% EBV associated -Non-Hodgkins - may be associated w/HIV or immunosuppression |
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CD30+ and CD15+ indicates?
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Reed Sternberg cells
B-cell origin binucleate or bilobed "owl eyes" "necessary but not sufficient for dx of Hodgkin's dz" |
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localized, single group of nodes with...
1.) collagen banding & lacunar cells young woman? 2.) numerous binucleate cells? 3.) man under 35? 4.) older man? |
1.) Nodular sclerosing (65-75%)
-excellent prognosis -many lymphocytes, few RS 2.) Mixed Cellularity (25%) -intermediate prognosis -many lymphocytes, many reed sternberg cells 3.) Lymphocyte predominant (6%) -excellent prognosis -many lymphocytes, few reed sternbergs 4.) Lymphocyte depleted (rare) -poor prognosis (older males w/disseminated dz) -RS high relative to lymphocytes, but few lymphocytes |
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lacunar cells in lymphoma?
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Nodular sclerosing Hodgkin's
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how to distinguish leukemoid reaction from leukemia?
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increased LAP in leukemoid reaction
neutrophils out to "LAP" up the infection in leukemia they're partying, no intention of fighting infection |
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Translocations, what gene, what dz?
t(8,14) t(11,14) t(14,18) |
t(8,14)
-c-myc moves to IgH -Burkitt's lymphoma t(11,14) -cyclin D moves to IgH -mantle cell lymphoma t(14,18) -bcl2 moves to IgH -follicular lymphoma |
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lymph node biopsy w/sheets of lymphocytes interspersed w/macrophages?
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Burkitt's lymphoma
"starry sky" t(8,14) - c-myc adolescents or young adults EBV associated Jaw - endemic form in Africa Pelvis/abdomen - sporadic form |
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MC adult NHL?
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diffuse large B-cell lymphoma
(many things progress to this) usually in older adults 20% in children May be mature T cell in origin (20%) |
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lymphoma w/CD5+?
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Mantle cell lymphoma
t(11,14) - cyclin D older males |
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NHL difficult to cure w/indolent course?
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Follicular lymphoma
t(14,18) - BCL2 (inhibits apoptosis) adults |
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lymphoma presenting w/cutaneous lesion?
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Adult T-cell lymphoma
HTLV-1 causes presenting w/cutaneous lesions affects Japan, West Africa, Caribbean aggressive adults |
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lymphoma presenting w/cutaneous patches / nodules?
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Mycosis fungoides
Sezary syndrome indolent CD4+ adults |
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patient w/EBV is found to have mediastinal lymphadenopathy?
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Hodgkin's lymphoma
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