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41 Cards in this Set

  • Front
  • Back
Short acting insulins?
insulin, lispro
intermediate insulins?
long acting insulins?
lente, ultralente
MOA of insulin?
liver (increased glucose stored as glycogen) Muscle (increased glycogen and protein synth, K uptake) Fat (aids TG storage)
Uses of insulin other than DM1?
life threatening hyperkalemia and stress induced hyperglycemia
Insulin toxicity?
hypoglycemi, hypersensitivity rxn (very rare)
Name the first generation sulfonylureas.
tolbutamide, chlorpropamide
name the second generation sulfonylureas.
glyburide, glimeperide, glipizide
MOA of sulfonylureas.
close K channel in beta cell membrane so cell depolarizes…triggers insulin release via increased Ca influx
Are sulfonylureas good for DM1, DM2 or both?
DM2. (useless in DM1 b/c needs some islet fxn)
First generation sulfonylureas toxicities?
disulfiram-like effects
Second generation sulfonylurea toxicity?
What class of drugs is metformin?
Probable MOA of metformin?
decreased GNG, increased glycolysis, decreased serum glucose
Metformin for DM1, DM2 or both?
Metformin toxicity?
lactic acidosis (contraindicated in renal insufficiency, CHF, elderly)
MOA of glitazones?
increased target cell response to insulin
Glitazones, DM1, DM2 or both?
Glitazone toxicities/
weight gain, CHF (fluid retention), (troglitazone is hepatotoxic)
name two alpha glucosidase inhibitors.
acarbose, miglitol
alpha glucosidase inhibitor MOA?
inhibit intestinal brush border alpha glucosidases (delayed sugar hydrolysis and glucose absorption lead to decreased postpradial hyperglycemia)
alpha glucosidase inhibitor toxicity?
Orlistat MOA?
alters fat metabolism by inhibiting pancreatic lipases
Indications for orlistat?
long term obesity management
Orlistat toxicities?
steatorrhea, GI discomfort, reduced absorption of fat soluble vitamins, HA
Sibutramine MOA?
sympathomimetic SNRI
Indication for sibutramine?
short-term and long term obesity management
Sibutramine toxicity?
HTN, tachycardia
Propylthiouracil, methimazole MOA?
inhibit organification and coupling of thyroid hormone synthesis. Propylthiouracil also decreases peripheral conversion of T4 to T3
Indications for propylthiouracil or methimazole?
Toxicities of propylthiouracil and methimazole?
skin rash, agranulocytosis (rare), aplastic anemia
Indication for somatostatin?
GH deficiency, turner's syndrome
Indication for octreotide?
acromegaly, carcinoid, gastrinoma, glucagonoma
Indication for oxytocin?
stimulates labor, uterine contractions, milk let-down; controls uterine hemorrhage
Indication for desmopressin?
Central (not nephrogenic) DI
Uses of levothyroxine, triiodothyroxine?
hypothyroidism, myxedema
Levothyroxine, triiodothyroxine toxicity?
tachycardia, heat intolerance, tremors
What kind of drug is triamcinolone?
MOA of glucocorticoids?
decreased production of leukotrienes/prostaglandins by inhibiting PLA2 and COX-2 expression
Uses of glucocorticoids?
addison's, inflammation, immune suppression, asthma
Glucocorticoid toxicity?
iatrogenic cushings (buff hump, moon facies, truncal obesity, muscle wasting, thin skin, easy bruisability, osteoporosis, adrenocortical atrophy, peptic ulcers)