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22 Cards in this Set
- Front
- Back
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Notochord develops into...
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nucleus pulposus of disc
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Craniopharyngioma
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bening tumor of Rathke's pouch with cholesterol crystals and calcifications,
adenohypohpyis of pituitary |
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Agensis vs. aplasia
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aplasia- absent organ despite primordial tissue being present
agenesis- no primodial tissue |
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Fetus most suceptible in 3-8th weeks to teratogens... what happens with lithium, valporate and phenytoin
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lithium- atrialized RV
valproate- neural tube defects phenytoin- fetal hydantoin syndrome, microcephaly, weird facial features, hypoplastic nails, distal phalanges, ardiac defects, MR, small |
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Meckel's diverticulum
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partial closure with paten portion attached to ileum, possible ectopic gastric mucosea, melena and periumbilical pain. Child with noninfectious bloody stool, 2 feet from ileocecal valve
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Formation of interventricular septum
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1. muscular ventricular septum forms, leaving an opening
2. AP septum meets and fuses with muscular to form membranous septum 3. endocardial cushions spearates atria from ventricles and ads to membranous interventricular septum path from improper neural crest migration in TPA, or septal defects |
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Fetal eryhtropoiesis over time
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3-8 weeks tolk sac
6-30 weeks liver 9-28 spleen 28+ bone marrow |
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Vascular post-natal derivatives
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umbilical vein- ligamentum teres
umbilical arteries- medial umbilical ligaments allantois- urachus- median umbilical ligament ductus arteriosus- ligamentum arteriosum |
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Findings in neural tube defects, when does error occur?
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Occurs in failure to fuse in 4th week
elevated AFP + acetylcholinesterase in CSF |
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Embryonic brain structures
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prosencephalon - leads to telenchepahlon and dienchepalon- becomes cerebrum and thalamus
mesenchephalon becomes the midbrain rhombencephalon- metenechphalon -> pons and cerebellum myelenchephalon leads to medulla |
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Chiari II
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cerebellar tonsillar herniation tough formaen magnum with aqueducatla stejosis and hydrocephally
Dandy-Walker- large posterior fossa, cystic enlargement of 4th ventricle, ydrocephalus and spina bifida |
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Syringomyelia
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enlargement of the central spinal cord canal, causes Cape-like bilateral loss of pain and temp sensation in upper extremities C8-T1 typically
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Aortic arches and later structures
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1st- maxillary artery
3rd- common carotid and proximal pary of internal 4th left, aortic arch, right, right subclavian 6th- pulmonary arteries |
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Branchial pouch malformation of 3rd and 4th pouches?
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DiGeorge- thymic aplasia and hypocalcemia
MEN2A- adrenal medulla, parathyroid 3rd/4th pharyngeal puch, parafolliclar cells derived from neural crest cells, assoicated with 4th/5th pharyngeal pouches |
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Gastroschisis vs. omphalocele
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gastroschisis- not covered by peritoneum
imphalocele organs covered by peritoneum |
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Duodenal atresia assoiated with
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trisomy 21
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What happens at 6th and 10th week in abdominal development?
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6th- herniation of midgut through umbilicus
10th- returns to abdomen rotating about superior mesennteric artery |
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Potter's syndrome
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bilateral renal agenesis leading to oligohydramins, limb deformites, facial deformities and pulmonary hypoplasia
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Horshoe kidney assoicated with
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turner syndrome, still have normal kidney functin, trapped under inferior mesenteric artery
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Mullerian inhibitory factory
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produced by sertoli cells and suppresses paramesonpehric ducts, androgens from leydig cells lead to develoment of mesonephric ducts
mesonephric- becomes seminal vesicles, epipdysmius, ductus eferens, ejac duct |
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What happens if there are no Sertoli cells?
What happens in 5 alpha reductase deificency? |
no sertoli stalles- no antimullerian hromone, both male and femal internal genitalia, male external genitalia
5a reductase deficit- male internal genitalia, ambiguous external, can't produce DHT which develops male external genitalia |
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Gubernaculum in females and males. What is it's fate?
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ovarian ligament/round ligament of uterus
anchors testes within scrotum |
