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21 Cards in this Set
- Front
- Back
- 3rd side (hint)
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amantadine MOA
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"a man to dine" take off his coat. Blocks viral penetration/ uncoating (M2 prot); may buffer pH of endosome. Release of dopamine from intact nerve terminals.
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amantadine clinical use
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Manatadine blocks influenza A and rubellA and causes problemms with the cerebellA. Tx for parkinsons
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amantadine toxicity
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ataxia, dizzyness, slurred speech
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amantadine mechanism of resistance
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mutated M2 prot. 90% flu resistant to amantadine. Rimantadine has less AE's and doesn’t X BBB
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zanamivir, oseltamivir MOA
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inhibits influenza neuraminidase. Progeny release decreased
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zanamivir, oseltamivir clinical use
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influenza A, B
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ribavirin MOA
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inhibits syn of guanine nucleotides by competitively inhibiting IMP dehydrogenase
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ribavirin clinical use
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RSV, chronic hep C
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ribavirin toxicity
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hemolytic anemia. Severe teratogen
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acyclovir MOA
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inhibits viral DNA pol when PHOSPHORYLATED BY VIRAL THYMIDINE KINASE
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acyclovir clinical use
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HSV, VZV, EBV. Mucocutaneous and genital herpes lesions. Prophylax in immunocompromised patients
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acyclovir toxicity
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delerium, tremor, nephrotoxicity
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acyclovir mech of resistance
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lack of thymidine kinase
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gancyclovir MOA
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phosphorylation by viral kinase. Pref inhibits CMV DNA polymerase
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gancyclovir clinical use
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CMV, esp in immunocompromised pts.
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gancyclovir toxicity
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leukopenia, neutropenia, thrombocytopenia, renal tox. More toxic to host enzymes than acyclovir
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None
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gancyclovir mech of resistance
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mutated CMV DNA polymerase or lack of thymidine kinase
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foscarnet MOA
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viral DNA pol inhibitor tha tbinds pyrophosphate binding site of the enz. DOES NOT REQUIRE ACTIVATION BY VIRAL KINASE
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foscarnet flinical use
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CMV retinitis in immuno comporomised when gancyclovir fails. Acyclovir resistant HSV
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foscarnet tox
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nephrotoxicity
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foscarnet mechanism of resistance
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mutated DNA polymerase
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