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27 Cards in this Set
- Front
- Back
- 3rd side (hint)
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atropine-like side effects
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tricyclics
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cardiac toxicity
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doxorubicin, daunorubicin
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coronary vasospasm
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cocaine
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None
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cutaneous flushing
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niacin (lipid lowerer, increases HDL), CCB, adenosine, vancomycin (red man syndrome!)
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torsades de pointes
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class III antiarrythm (sotalol), class IA antiarrhythm. (quinidine), cisapride
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agranulocytosis (3)
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clozapine (atypical antipsych, least EPS); carbamazepine (AED, mood stabilizer, P450 inducer); colchicine
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aplastic anemia
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chloramphenicol, benzene, NSAIDs; also: propylthioracil, methimazole (inhibit organificatin and coupling of thyroid hormone synth)
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None
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gray baby syndrome
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(ab distention, progressive pallid cyanosis, vasomotor collapse) chloramphenicol (binds 50s, inhibits peptidlytransferase)
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hemolysis in G6PD deficient pts
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sulfonamides, INH, aspirin, ibuprofen, primaquine, nitrofurantoin (abx)
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thrombotic complications
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OCPs
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cough
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ace inhibitors (bradykinin!)
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pulmonary fibrosis
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bleomycin (induces free radical formation, for testicular cacner, lymphomas--ABVD regimen); amiodarone (class IA antiarrhthm); busulfan (alkylates DNA, CML, also causes hyperpigmentation)
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acute cholestatic hepatitis
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macrolides (dont give to preggers!)
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focal to massive hepatic necrosis
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halothane (inhaled anesthetic); valproic acid; acetaminophen; Amanita phalloides (mushroom poison alpha amanitin-->inhibits euk RNA pol)
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gynecomastia
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Some Drugs Create AwesomE Knockers--Spironolactone, Digitalis, Cimetidine, Alcohol chronique, Estrogens, Ketoconazole
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gingival hyperplasia
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phenytoin
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osteoporosis
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corticosteroids, heparin
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photosensitivity
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sulfonamides, amiodarone, tetracycline; also 5-FU
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None
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SLE-like syndrome
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hydralazine (antiHTN for preggers, stim cGMP); INH; procainamide (Class IA antiarrh.); phenytoin
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Fanconi's syndrome
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expired tetracycline
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interstitial nephritis
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methicillin; also acute interstitial nephritis: NSAIDs, beta lactams, sulfa diuretics, phenytoin, cimetidine, methyldopa
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None
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hemorrhagic cystitis
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cyclophosphamide, ifosfamide
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diabetes insipidus
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lithium, demeclocycline
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seizures
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bupropion (heterocyclic antidepressant, no sexual side effects); imipenem/cilastin
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disulfiram-like reaction
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metronidazole, some cephalosporins, procarbazine (antineoplastic alkylator); sulfonylureas
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nephrotoxicity/neurotoxicity
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polymyxins
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nephrotoxicity/ototoxicty
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aminoglycosides, loop diuretics, cisplatin
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