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15 Cards in this Set
- Front
- Back
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Large-vessel vasculiti
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Temporal (giant cell) arteritis
Takayasu's arteritis |
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Medium-vessel vasculiti
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Polyarteritis nodosa
Kawasaki dz Buerger's dz (thromboangitis obliterans) |
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Small-vessel vasculiti
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Microscopic polyangitis
Wegener granulomatosis Churg-strauss syndrome |
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MC form childhood systemic vasculitis
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Henoch-Schonlein purpura
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elderly female
unilateral headache jaw claudication |
Temporal (giant cell) arteritis
[large-vessel vasculitis] can cause irreversible blindness from ophthalmic artery occlusion associated w/polymyalgia rheumatica affects branches of carotid artery focal granulomatous inflammation increased ESR tx: high dose steroids elderly females unilateral headache (temporal artery) jaw claudication |
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young asian woman
weak upper extremity pullses fever, night sweats arthritis, myalgias skin nodules ocular disturbances |
Takayasu's arteritis
[large-vessel vasculitis] "Pulseless dz" Granulomatous thickening of aortic arch, proximal great vessels increased ESR asian females < 40 weak upper extremity pullses fever, night sweats arthritis, myalgias skin nodules ocular disturbances |
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young male/female adult
fever, weight loss, malaise, headache abdominal pain, black tarry stool HTN neuro dysfxn cutaneous eruptions, different ages hepatitis b exposure |
Polyarteritis nodosa
[medium vessel vasculitis] involves: renal & visceral vessels (NOT pulmonary arteries) Immune-complex mediated transmural w/fibrinoid necrosis lesions are of different ages multiple aneurysms & constrictions on arteriogram Tx: corticosterpoids, cyclophosphamide Young adults 30% HBV seropositive fever, weight loss, malaise, headache abdominal pain, melena HTN neuro dysfxn cutaneous eruption |
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transmural w/fibrinoid necrosis
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Polyarteritis nodosum
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3 yo asian child
fever, lymphadenitis conjunctivitis changes in lips/oral mucosa "strawberry tongue" hand-foot erythema, desquamation |
Kawasaki Dz
[medium-vessel vasculitis] (young kids sock each other; foot rash) may develop coronary aneurysms tx w/IV immunoglobulin & aspirin asian children < 4 yo fever, lymphadenitis conjunctivitis changes in lips/oral mucosa "strawberry tongue" hand-foot erythema, desquamation |
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28 yo male smoker
intermittent leg pain superficial nodes cold sensitivity/pain |
Buerger's Dz
[medium vessel vasculitis] Segmental thrombosing vasculitis Tx: smoking cessation Heavy smokers Males < 40 yo Intermittent claudication --> gangrene, autoamputation of digits, superficial nodular phlebitis Raynaud's phenomenon from neural involvement (cold sensitivity, severe pain of affected part at rest) |
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palpable purpura
glomerulonephritis (RBC casts, etc) |
Microscopic polyangitis
[small vessel vasculitis] pauci-immune glomerulonephritis palpable purpura no granuloma p-ANCA |
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perforated nasal septum
chronic sinusitis, otitis media, mastoiditis hemoptysis, cough, dyspnea hematuria, red cell casts |
Wegener's granulomatosis
[small-vessel vasculitis] Triad: 1.) focal necrotizing VASCULITIS 2.) necrotizing granulomas in the LUNG and upper airway 3.) necrotizing GLOMERULONEPHRITIS c-ANCA CXR - large nodular densities Tx w/cyclophosphamide, corticosteroids Upper Resp Tract: perforated nasal septum chronic sinusitis, otitis media, mastoiditis Lower Resp Tract: hemoptysis, cough, dyspnea Renal: hematuria, red cell casts |
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CXR - large nodular densities
c-ANCA positive |
Wegener's granulomatosis
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asthma
sinusitis non-blanching lesions wrist or foot drop |
Churg Strauss Syndrome
[small-vessel vasculitis] pauci-immune grarnulomatous vasculitis w/EOSINOPHILIA p-ANCA asthma, sinusitis palpable purpura peripheral neuropathy (wrist/foot drop) can also involve: HEART GI KIDNEY |
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child w/recent upper resp infection
non-blanching lesion on buttocks painful joints abdominal pain, black tarry stool "multiple lesions of same age" |
Henoch-Schonlein purpura
(MCC childhood systemic vasculitis) IgA immune complexes associated w/IgA nephropathy Follows URIs Triad: 1.) Skin - palpable purpura on buttocks/legs 2.) Arthralgia 3.) GI - abdominal pain, melena, multiple lesions of same age |
