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15 Cards in this Set

  • Front
  • Back
Large-vessel vasculiti
Temporal (giant cell) arteritis
Takayasu's arteritis
Medium-vessel vasculiti
Polyarteritis nodosa
Kawasaki dz
Buerger's dz (thromboangitis obliterans)
Small-vessel vasculiti
Microscopic polyangitis
Wegener granulomatosis
Churg-strauss syndrome
MC form childhood systemic vasculitis
Henoch-Schonlein purpura
elderly female
unilateral headache
jaw claudication
Temporal (giant cell) arteritis
[large-vessel vasculitis]

can cause irreversible blindness from ophthalmic artery occlusion
associated w/polymyalgia rheumatica

affects branches of carotid artery
focal granulomatous inflammation
increased ESR

tx: high dose steroids

elderly females
unilateral headache (temporal artery)
jaw claudication
young asian woman
weak upper extremity pullses
fever, night sweats
arthritis, myalgias
skin nodules
ocular disturbances
Takayasu's arteritis
[large-vessel vasculitis]

"Pulseless dz"

Granulomatous thickening of aortic arch, proximal great vessels
increased ESR

asian females < 40
weak upper extremity pullses
fever, night sweats
arthritis, myalgias
skin nodules
ocular disturbances
young male/female adult
fever, weight loss, malaise, headache
abdominal pain, black tarry stool
HTN
neuro dysfxn
cutaneous eruptions, different ages
hepatitis b exposure
Polyarteritis nodosa
[medium vessel vasculitis]

involves: renal & visceral vessels (NOT pulmonary arteries)
Immune-complex mediated
transmural w/fibrinoid necrosis
lesions are of different ages

multiple aneurysms & constrictions on arteriogram

Tx: corticosterpoids, cyclophosphamide

Young adults
30% HBV seropositive
fever, weight loss, malaise, headache
abdominal pain, melena
HTN
neuro dysfxn
cutaneous eruption
transmural w/fibrinoid necrosis
Polyarteritis nodosum
3 yo asian child
fever, lymphadenitis
conjunctivitis
changes in lips/oral mucosa "strawberry tongue"
hand-foot erythema, desquamation
Kawasaki Dz
[medium-vessel vasculitis]
(young kids sock each other; foot rash)

may develop coronary aneurysms

tx w/IV immunoglobulin & aspirin

asian children < 4 yo
fever, lymphadenitis
conjunctivitis
changes in lips/oral mucosa "strawberry tongue"
hand-foot erythema, desquamation
28 yo male smoker
intermittent leg pain
superficial nodes
cold sensitivity/pain
Buerger's Dz
[medium vessel vasculitis]

Segmental thrombosing vasculitis

Tx: smoking cessation

Heavy smokers
Males < 40 yo
Intermittent claudication --> gangrene, autoamputation of digits, superficial nodular phlebitis
Raynaud's phenomenon from neural involvement (cold sensitivity, severe pain of affected part at rest)
palpable purpura
glomerulonephritis (RBC casts, etc)
Microscopic polyangitis
[small vessel vasculitis]

pauci-immune glomerulonephritis
palpable purpura

no granuloma
p-ANCA
perforated nasal septum
chronic sinusitis, otitis media, mastoiditis

hemoptysis, cough, dyspnea

hematuria, red cell casts
Wegener's granulomatosis
[small-vessel vasculitis]

Triad:
1.) focal necrotizing VASCULITIS
2.) necrotizing granulomas in the LUNG and upper airway
3.) necrotizing GLOMERULONEPHRITIS

c-ANCA
CXR - large nodular densities

Tx w/cyclophosphamide, corticosteroids

Upper Resp Tract:
perforated nasal septum
chronic sinusitis, otitis media, mastoiditis

Lower Resp Tract:
hemoptysis, cough, dyspnea

Renal:
hematuria, red cell casts
CXR - large nodular densities
c-ANCA positive
Wegener's granulomatosis
asthma
sinusitis
non-blanching lesions
wrist or foot drop
Churg Strauss Syndrome

[small-vessel vasculitis]

pauci-immune
grarnulomatous vasculitis w/EOSINOPHILIA

p-ANCA

asthma, sinusitis
palpable purpura
peripheral neuropathy (wrist/foot drop)

can also involve:
HEART
GI
KIDNEY
child w/recent upper resp infection
non-blanching lesion on buttocks
painful joints
abdominal pain, black tarry stool
"multiple lesions of same age"
Henoch-Schonlein purpura
(MCC childhood systemic vasculitis)

IgA immune complexes
associated w/IgA nephropathy

Follows URIs

Triad:
1.) Skin - palpable purpura on buttocks/legs
2.) Arthralgia
3.) GI - abdominal pain, melena, multiple lesions of same age