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20 Cards in this Set

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fat soluble vitamins?
ADEK
toxicity more common (than water souble) b/c accumulate in fat
common cause of fat soluble vitamin deficiencies?
malabsorption syndromes (steatorrhea)
-cystic fibrosis
-sprue

or mineral oil intake
which water soluble vitamins do not wash out of the body easily?
B12 and folate, which are stored in the liver
common cause of dermatitis, glossitis, and diarrhea?
B-complex deficiencies
vitamin A is used to treat?
measles
AML, subtype M3
vitamin A's name? found?
retinol
found in liver & leafy vegetables
vitamin A function?
retinol

antioxidant
constituent of visual pigments
essential for normal differentiation of epithelial cells into specialized tissue (pancreatic cells, mucus-secreting cells)
prevents squamous metaplasia
vitamin deficiency - night blindness, dry skin?
Vitamin A
vitamin excess - arthralgias, fatigue, headaches, skin changes, sore throat, alopecia?
Vitamin A
(also is teratogenic)
vitamin that is teratogenic? causes?
vitamin A
cleft palate, cardiac abnormalities
before prescribing isotretoin for acne what must be done?
pregnancy test
Vitamin A is teratogenic
Vitamin B1 name? MOA?
Thiamine pyrophosphate (TPP)
cofactor for DECARBOXYLATION rections
-Pyruvate dehydrogenase (TCA)
-alpha ketoglutarate dehydrogenase (TCA cycle)
-Transketolase (HMP shunt)
-Branched chain AA dehydrogenase
what enzyme is involved in decarboxylation reactions?
Thamine, B1
vitamin deficiency - impaired glucose breakdown, ATP depletion (worsened by glucose infusion)?
Thiamine, B1 deficiency
seen in alcoholism & malnutrition
highly aerobic tissues effected first (brain & heart)
Wernicke-Korsakoff; berberi
polyneuritis, symmetrical mm wasting?
dry beriberi
Thiamine, B1 deficiency
high-output cardiac failure, edema?
wet beriberi
thiamine, B1 deficiency
(dilated cardiomyopathy)
confusion, opthalmoplegia, ataxia, confabulation, personality change?

what is damaged?
what is permanent effect?
Wernicke-Korsakoff
Thiamine, B1

-damage to medial dorsal nucleus of thalamus, mammillary bodies
-permanent memory loss
Vitamin B2 name? MOA?
Riboflavin
cofactor in OXIDATION and REDUCTION (FADH2)
-FAD & FMN are dervied from riboflavin
what vitamin is involved in oxidation and reduction?
Vitamin B2, riboflavin
vitamin deficiency - inflammation of lips, scaling and fissures at corner of mouth; vascularization of the cornea?
Vitamin B2, riboflavin deficiency

2 Cs of B2 - cheliosis and corneal vasc.