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48 Cards in this Set
- Front
- Back
|
Diphenhydramine
mech |
H1 blocker
1st generation |
|
|
diphenhydramine
use |
allergy
motion sickness insomnia |
|
|
diphenyhydramine
se |
sedation
antimuscarinic anti-alpha-adrenergic |
|
|
dimenhydrinate
mech |
h1 blocker
1st generation |
|
|
dimenhydrinate
use |
allergy
motion sickness sleep aid |
|
|
dimenhydrinate
se |
sedation
antimuscarinic anti alpha adrenergic |
|
|
chlorpheniramine
mech |
h1 blocker
1st generation |
|
|
chlorpheniramine
use |
allergy
motion sickness insomnia |
|
|
chlorpheniramine
se |
sedation
antimuscarinic anti alpha adrenergic |
|
|
loratadine
mech |
h1 blocker
2nd generation |
|
|
loratadine
use |
allergy
|
|
|
2nd gen h1 blocker
se |
less sedating than 1st gens
b/c less cns entry |
|
|
fexofenadine
mech |
h1 blocker
2nd gen |
|
|
fexofenadine
use |
allergy
|
|
|
desloratadine
mech |
h1 blocker
2nd gen |
|
|
desloratadine
use |
allergy
|
|
|
cetirizine
mech |
2nd gen h1 blocker
|
|
|
cetirizine
use |
allergy
|
|
|
albuterol
mech |
beta 2 agonist
relax bronchial smooth m. |
|
|
albuterol
use |
acute asthma
|
|
|
salmeterol, formoterol
mech |
b2 agonist
dilate bronchial smooth m. |
|
|
salmeterol, formoterol
use |
long-acting agents for prophylaxis
|
|
|
salmeterol, formeterol
se |
tremor
arrythmia |
|
|
theophylline
mech |
methylxanthine
bronchodilation inhibit phophodiesterase less camp breakdown blocks adenosine (bronchonconstrictor) |
|
|
theophylline
use |
limited use b/c of narrow therapeutic index
asthma |
|
|
theophylline
se |
cardiotox
neurotox |
|
|
ipratropium
mech |
long acting competitive muscarinic receptor antagonist
preventing bronchoconstriction |
|
|
ipratropium
use |
asthma
COPD |
|
|
cromolyn
mech |
steroid
prevent mast cell stuff release |
|
|
cromolyn
use |
only asthma prophylatic!
not effective for acute |
|
|
beclomethasone, fluticasone (resp)
mech |
inhibit synthesis of cytokines (almost all!)
inactivate NF-kappa B -> transcirption factor makes TNF alpha et al |
|
|
beclomethasone, fluticasone (resp)
use |
1st line tx for chronic asthma
|
|
|
montelukast, zafirlukast
mech |
block leukotriene receptors
|
|
|
montelukast, zafirlukast
use |
especially good for aspirin induced asthma
|
|
|
zileuton (resp)
mech |
5-lipoxygenase pathway inhibitor
blocks arachidonic acid conversion to leukotrienes |
|
|
zileuton (resp)
use |
asthma
|
|
|
guafinesin
mech |
robitussin
expectorant thins respiratory secretions Does not suppress cough reflex |
|
|
n-acetylcysteine - resp
mech |
expectorant
mucolytic loosen mucus plugs |
|
|
n-acetylcysteine - resp
use |
cystic fibrosis
acetaminophen overdose |
|
|
bosentan
mech |
competitively antagonizes endothelin-1 receptors
less pulmonary vessel resistance |
|
|
bosentan
use |
pulmonary htn
|
|
|
Omalizumab
mech |
monoclonal anti-IgE antibody. binds mostly unbound serum IgE.
|
|
|
Omalizumab
use |
used in allergic asthma resistant to inhaled steroids and long acting beta-2 agonists
|
|
|
dextromethorphan
|
antitussive (antagonizes NMDA glutamate receptors). Synthetic codeine analog. Has mild opioid effect when used in excess.
|
|
|
dextromethorphan overdose
|
naloxone
|
|
|
pseudoephedrine, phenylephrine MOA
|
sympathomimetic alpha-agonist nonprescription nasal decongestants
|
|
|
pseudoephedrine, phenylephrine clinical use
|
reduce hyperemia, edema, and nasal congestion; open obstructed eustachian tubes
Pseudoephedrine also used as a stimulant |
|
|
methacholine
|
muscarinic receptor agonist. Used in asthma challenge testing
|
