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43 Cards in this Set

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Pt has flushed cheeks and dilated pupils. Cause? Antagonism of muscarinic receptors. Drugs responsible?
Atropine
TCAs (amitryptiline)
H1 Receptor antagonists (diphenhydramine)
Neuroleptics
Anti-Parkinson's Disease drugs
Atropine-like side effects
(increased body temp from decreased sweating, rapid pulse, dry mouth, dry, flushed skin, cycloplegia, constipation, disorientation)
TCAs

Remember atropine-like SEs
"Hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter"
Coronary vasospasm:
caused by Cocaine, sumatriptan
Cutaneous flushing:
VANC:
Vancomycin
Adenosine
Niacin
Calcium Channel blockers
Dilated Cardiomyopathy:
Doxorubicin

"doxorubicin rubs the heart the wrong way"
Torsades de pointes:
Class III and 1A antiarrhythmics

Class III: K+ channel blockers (amiodarone, sotalol, ibutilide, bretylium, dofetilide)

Class 1A: Na Channel blockers (quinidine, procainamide, disopyramide)
Agranulocytosis:
Clozapine, Carbamazepine, colchicine,

propylthiouracil and methimazole (anti-hyperthyroid),

dapsone

"Got leprosy? Dap some of this on"
Aplastic anemia:
Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole
Direct Coombs-Positive hemolytic anemia:
Methyldopa
Gray baby syndrome:
Chloramphenicol

"ChlorampheniColored baby"
Hemolysis in G6PD deficiency:
Hemolysis IS PAIN

Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

nitrofurantoin treats UTIs
Megaloblastic anemia:
Phenytoin, Methotrexate, Sulfa drugs
Thrombotic complications:
OCPs (estrogen and progestins)
Cough:
ACE-Inhibitors

With ARBs, like Losartan, there's no cough
Pulmonary fibrosis:
Bleomycin, Amiodarone, Busulfan

Pulmonary fibrosis is a restrictive lung disease

Busulfan alkylates DNA. "Busulfan busts bone marrow" tx CML and to ablate bone marrow prior to transplant
Acute Cholestatic Hepatitis:
Macrolides--

Erythromycin, Azithromycin, Clarithromycin
Hepatic necrosis:
Halothane, valproate, acetominophen, α-amanitin (toxin from Amanita phalloides death cap mushroom)
Hepatitis:
Isoniazid

tx for tuberculosis
Pseudomembranous colitis:
Clindamycin, Ampicillin

"C. dif is AMP'd that you took ampicillin"
Adrenocortical insufficiency:
from glucocorticoid withdrawal

(due to HPA suppression from exogenous steroid therapy)
Gynecomastia:
Some Drugs Create Awesome Knockers--

Spironolactone, Digitalis, Cimetidine, Alcohol use (chronic), estrogens, Ketoconazole,
Hot flashes:
Tamoxifen, Clomiphen (blocks estrogen receptors in hypothalamus, purpose is to block negative feedback on GnRH to increase secretion in infertile patients to induce ovulation)
Hypothyroidism:
Lithium, amiodarone
Gingival Hyperplasia:
Phenytoin

Also causes Lymphadenopathy
Gout:
Furosemide, thiazide diuretics
Osteoporosis:
Corticosteroids, heparin
Photosensitivity:
Sulfonamides, Amiodarone, Tetracycline
Rash (Steven's Johnson Syndrome)
Ethosuximide, lamotrigine, carbamazepine, phenobarbital, phenytoin, sulfa drugs, penicillin, allopurinol
SLE-like symptoms:
Hydralazine, Isoniazid, Procainamide, Phenytoin

-it's not HIPP to have lupus
Tendonitis, tendon rupture, and cartilize damage in kids
Fluoroquinolones
Fanconi's syndrome:

a disease of the proximal renal tubules of the kidney in which glucose, amino acids, uric acid, phosphate and bicarbonate are passed into the urine, instead of being reabsorbed
Expired tetracycline
Interstitial nephritis:
Methicillin, NSAIDs, furosemide

Methicillin inhibits peptidoglycan cross-linking (same as penicillin), used for non-MRSA S. Aureus
Hemorrhagic cystitis:
Cyclophosphamide, ifosfamide (prevent ifosfamide-induced hemorrhagic cystitis by coadministering mesna)
Cinchonism:

the term for a quinine overdose
Quinidine, quinine
Diabetes insipidus:
Lithium, demeclocycline

(Demeclocycline is a tetracycline antibiotic)
Parkinson-like syndrome
haloperidol, chlorpromazine, reserpine, metoclopramide (a D2 antagonist, used for anti-emesis)
Seizures:
Buproprion, impenem/cilastatin, isoniazid
Tardive Dyskinesia:
Antipsychotics
Disulfiram-like reaction:
Metronidazole , Cephalosporins, procarbazine, 1st-gen sulfonylureas (tolbutamide, chlorpropramide).
Nephrotoxicity and Neurotoxicity:
Polymixins
Nephrotoxicity and Ototoxicity:
Aminoglycosides, vancomycin, loop diuretics, cisplatin.
P-450 Inducers:
Carbamazepine, Phenobarbital, Phenytoin, Rifampin, Griseofulvin
P-450 Inhibitors:
Cimetidine, Ciprofloxacin, Erythromycin, Azole antifungals, Isoniazid, Ritonavir (protease inhibitors), Grapefruit juice.