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15 Cards in this Set
- Front
- Back
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Bernard-Soulier Disease
-Platelet count -Bleeding time -MOA? |
PC
-Decreased BT -Increased MOA -Platelet disorder -Defect in platelet plug formation -Decrease in Gp1b which leads to defect in platelet-to-collagen adhesion |
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Glanzmann's thrombasthenia
-Platelet count -Bleeding time -MOA? -Labs |
PC
-N/A BT -Increased MOA -Platelet disorder -Defect in platelet plug formation -Decrease in GpIIb/IIIa which leads to decrease in platelet-platelet aggregration Labs -Blood smear has NO platelet clumping |
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Idiopathic thrombocytopenic purpura (ITP)
-Platelet count -Bleeding time -MOA -Labs |
PC
-Decreased BT -Increased MOA -Decreased platelet survival -Anti-GpIIb/IIIa antibodies which leads to peripheral platelet destruction Labs -Increased megakaryocytes |
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Thrombotic Thrombocytopenic Purpura (TTP)
-Platelet count -Bleeding time -MOA |
PC
-Decreased BT -Increased MOA -Decreased platelet survival -Deficiency of ADAMTS 13 (vWF metalloprotease) -Leads to decrease in degradation of vWF multimers |
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Thrombotic Thrombocytopenic Purpura (TTP)
-Pathogenesis -Labs (2) -Symptoms (4) |
Pathogenesis
-Increase in large vWF multimers -Leads to increased platelet aggregration and thrombosis Labs -Schistocytes -Increase in LDH Symptoms -Pentad of neurologic and renal symptoms -Fever -Thrombocytopenia -Microangiopathic hemolytic anemia |
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PT test
-Tests which factors? (5) -Tests which pathway? |
Factors
-I, II, V, VII and X Pathway -Extrinsic -If defect then there is an increase in PT |
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PTT test
-Tests which factors? -Tests which pathway? |
Factors
-All factors except VII and XIII Pathway -Intrinsic pathway -If defect then there is an increase in PTT |
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Hemophilia A or B
-PT? -PTT? |
PT
-N/a PTT -Increased |
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Hemophilia A or B
-Defect in which pathway? -MOA (A and B) -Presentation (4) |
Pathway
-Intrinsic pathway coagulation defect MOA -A = deficiency of factor VIII (increase PTT) -B = deficiency of factor IX (increase PTT) Presentation -Macrohemorrhage -Hemarthroses (bleeding into joints) -Easy bruising -Increase PT and/or PTT |
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Vitamin K deficiency
-PT? -PTT? -MOA? |
PT
-Increased PTT -Increased MOA -General coagulation defect -Decreased synthesis of factors II, VII, IX, X protein C, protein S |
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von Willebrand's disease
-Platelet count -Bleeding time -PT -PTT |
PC
-Unchanged BT -Increased PT -Unchanged PTT -Unchanged or increased |
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von Willebrand's disease
-MOA -Pathway it affects? -Incidence? |
Pathway
-Intrinsic pathway coagulation defect MOA -Decrease in vWF -vWF acts to carry/protect factor VIII -Defect in platelet plug formation -Decrease in vWF leads to defect in platelet-to-collagen adhesion -Mild but most common inherited bleeeding disorder -Normal or increased PTT depending on severity |
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DIC
-Platelet count -Bleeding time -PT -PTT |
PC
-Decreased BT -Increased PT -Increased PTT -Increased |
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DIC
-MOA -Labs (3) |
MOA
-Widespread activation of clotting factors leads to deficiency in clotting factors -Creates a bleeding state Labs -Schistocytes -Increased fibrin split products (D-Dimers) -Decreased factors V and VIII |
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DIC
-Causes (7) |
Causes
-STOP Making New Thrombi -Sepsis (gram-negative) -Trauma -Obstetric complications -acute Pancreatitis -Malignancy -Nephrotic syndrome -Transfusion |
