Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
22 Cards in this Set
- Front
- Back
|
Interferes with cell cycle of activated lymphoid cells
Inhibits proinflammatory mediators Inhibit leukocyte chemotaxis |
Prednisone
|
|
|
Binds to cyclophilin inh. cytoplasmic phosphatase no calcineurin
(essential for the activation of the T-cell transcription factor NF-AT) NF-AT interleukin synthesis |
Cyclosporine
|
|
|
Similar to cyclosporine
FK binding protein (FK-BP) instead. |
Tacrolimus
|
|
|
what are Tacrolimus and Cyclosporine used for
|
organ transplants
they are nephrotoxic |
|
|
Similar to tacrolimus (FK-BP)
Except, does not inhibit calcineuron. inhibits mTOR (G1S phase) |
Sirolimmus
|
|
|
Inhibit cell proliferation
Activate NK cells |
Interferon alpha & beta
|
|
|
Interferon alpha & beta
difference? |
both:
Melanoma RCC CML just alpha: HBV & HCV just beta: Multiple sclerosis |
|
|
Derivative of mercaptopurine
inhibits de novo purine synthesis |
Azathioprine
|
|
|
Azathioprine tox?
|
Myeloid suppression
may increase with allopurinal |
|
|
Hydrolyzed in GI tract mycophenolic acid
Reversible inhibitor of inosine monophosphate dehydrogenase Blocks de novo formation of guanasine phosphate |
Mycophenolate mofetil
|
|
|
Mycophenolate mofetil is like? used for?
|
6-MP
Graft rejection **replacing Azathioprine because it’s safer and is better to stop graft rejection |
|
|
binds the epidermal growth factor receptor, HER-2/neu
Downregulates the receptor |
Trastizumab
|
|
|
Trastizumab
|
Breast cancer
|
|
|
binds CD20 on normal & malignant B cells
Activates complement-mediated lysis, ADCC and apoptosis. |
Rituximab
|
|
|
Rituximab
|
Follicular B-cell non-hodgkin’s
|
|
|
binds CD25 fxns as IL-2 antagonist Suppresses lymphocyte activation
|
Daclizumab
|
|
|
Daclizumab
|
Organ transplant
( + glucocorticoids & cyclosporine) |
|
|
same characteristics as daclizumab, but higher affinity
|
Basiliximab
|
|
|
Binds to fusion protein for RSV
Prevents infection of the cell |
Palivizumab
Neonates at risk for RSV |
|
|
Binds CD80 & CD86 (APC) blocks interaction with CD28 (on t cell)
Inhibition of autoimmune T cell activation! |
Abatacept
|
|
|
Abatacept
|
Rheumatoid arthritis
|
|
|
admin to Rh- mother w/in 72hrs after delivery of Rh+ baby
inh. B cell memory cell formation |
Rh D antibody
(anti-D Ab) hemolytic dz of newborn |
