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5 Cards in this Set
- Front
- Back
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RAS-d |
Ras cannot hydrolyze GTP, it's always associated with RAF, to make it you sterically block the gamma phosphate (G12-X amino acid change most often or Glu61-X) |
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Kras |
Most common. G12 is mutational hotspot. |
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Rigosertib, lonafarnib, and vemurafenib |
Rigosertib: Blocks Ras ability to bind to RAF. Lonafarnib: prevents lipid attachment to Ras (unsuccessful) Vemurafenib: inhibits downstream effectors |
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Imatinib/gleevec |
Blocks BCR-abl kinase's substrate binding domain |
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P61B-RafV600E |
Resistant to vemurafenib |
