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8 Cards in this Set
- Front
- Back
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What class of antibiotics contains Fidaxomicin?
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Macrocyclic
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What is the mechanism of action of Fidaxomicin?
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Inhibition of RNA polymerase
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What is the mechanism of resistance to Fidaxomicin?
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Mutations on RNA polymerase where Fidoxamicin binds
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What bacteria is Fidaxomicin particularly good at killing? Why?
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C. difficile.
Why? It is concentrated into the intestine |
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What is the absorption of Fidaxomicin?
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Minimal when given orally.
This is how it is given though, because it targets GI bugs on the mucosal surface. |
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Where is the distribution of Fidaxomicin?
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Confined primarily to the intestine
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What is the metabolism of Fidaxomicin?
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The bug is hydrolyzed to an active metabolite.
Half life = 11.7 hours. |
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What is the excretion of Fidaxomicin?
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Fecally.
This MAKES SENSE: it isn't absorbed and doesn't go anywhere else than the intestine! |
