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4 Cards in this Set
- Front
- Back
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Alteplase (tPA)
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Converts Plasminogen to Plasmin.
Needs FIBRIN to work Indications: MI, CVA, Pulmonary Embolism. Used in ischemic strokes, not hemorrhagic strokes Adverse effects: Hemorrhage |
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Streptokinase
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Causes degradation of fibrinogen, fibrin, factors V and VII
Indications: MI, DVT, PE, CVA and other arterial thromboses Adverse Effects: Hemorrhage and fibrinogen, factor V and VII depletion |
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Urokinase
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Approved for Pulmonary emboli but also used for DVT, MI, arterial thromboembolisms
Low antigenicity, highly specific for fibrin made in kidney can cause severe hemorrhage |
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Fibrinolytic/Thrombolytic Drugs:
tPA Streptokinase Urokinase |
CONTRAINDICATIONS:
Surgery within 10 days GI Bleeding in last 3 months HTN Aortic Dissection Acute Pericarditis Previous hemorrhagic CVA Active bleeding |
