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12 Cards in this Set
- Front
- Back
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What is the result of excessive prolactin secretion?
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Excessive lactation, suppression of gonadotropins (loss of menstruation in women - secondary ammenorrhea), suppression of ovulation. Loss of libido in males.
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What 2 hormones suppress prolactin?
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Somatostatin and dopamine.
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What would cause infarction of the pituitary?
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Decreased blood flow in the portal circulation (very low pressure), increased demand of the hypothalamus, increased demand of pituitary without accompanied increase in blood supply.
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What causes acromegaly?
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Increased GH.
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What peptide is stimulated by GH to act on tissues?
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IGF-1.
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Why would a patient with acromegaly experience tingling in his hands?
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Carpal tunnel.
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Why would a patient with acromegaly experience joint pain?
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Arthritis from overgrowth of bone and cartilage.
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What is the effect of glucose on plasma GH levels?
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Glucose cause release of insulin, which will drive down GH. In this case, pancreas releases insulin but its effects are blocked on the muscle and liver.
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What secondary pathology results in patients with acromegaly?
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Insulin resistance and type 2 diabetes due to tonically high levels of insulin in the circulation.
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Why would acromegaly patients become impotent?
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Pituitary is compressed/damaged, blood flow may be cut off to the pituitary, or prolactin might be oversecreted due to high levels of GH.
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What molecule made in the hypothalamus might be helpful in treating acromegaly patients?
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Somatostatin or its analog.
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Why might impairment of visual field occur?
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Compression of the optic chiasm caused by a macrotumor.
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