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13 Cards in this Set
- Front
- Back
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When are abnormal sperm removed?
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when the sperm enter the cervix/uterus
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where is capacitation initiated?
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in the uterus
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where is capacitation completed?
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in the oviduct
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when does the acrosome reaction take place?
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fertilisation. sperm penetrates oocyte
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where does the sperm gain hyperactive motility?
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ampulla of oviduct
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what are the 4 steps in capacitation?
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decapacitation factors coating sperm head are removed
exposure of Zona Pellucida binding sites surface charge altered membrane fluidity increased to aid breakdown of acrosome |
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what leads to increased cAMP levels and hyperactivation?
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increased intracellular calcium
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what does the sperm bind to the zona pellucida via?
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ZP3
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how many ZP3 does sperm binding require?
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50,000
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what causes spillage of the acrosomal contents?
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sperm plasma membrane and outer acrosomal membrane fuse causing vesiculation producing pores
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what are the enzymes released to digest zona pellucida?
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hyaluronidase and acrosin
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what 2 things are exposed during the acrosome reaction?
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equatorial segment of sperm head anf inner acrosomal membrane.
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what are the 6 steps of fertilisation?
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acrosomal enzymes digest small hole in zona pellucida
rapid penetration sperm move into perivitelline space between oocyte and zona pellucida oocyte plasma membrane fuses with sperm equatorial segment sperm engulfed then nuclear breakdown and formation of male and female pronucleuses corticol granules from the oocyte move into perivitelline space to cause zona block to prevent polysperming |
