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10 Cards in this Set
- Front
- Back
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all carrier proteins have a Tm except for ____. why?
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the carrier protein carrying Na. B/c aldosterone can upregulate it.
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explain why we get edema in CHF
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heart not f'ning as a pump --> low effective circulating volume --> therefore conserve salt (thus, retain water)
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how Na (i.e. volume) is regulated (where are the sensors and what do they do?
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VENOUS
1. atrial stretch sensors -> ANP (decreases ADH, decrease vascular resis) 2. nerves adjacent to pulm caps -> inhibit SNS ARTERIAL 1. carotid and aortic baroreceptors --> natriuresis 2. renal BP --> natriuresis CHEMORECEPTORS sensor Na+ concentration rather than volume |
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3 ways AII will cause Na conservation
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1. vasoconstrict efferent arteriole
2. Na reabsorp in PT 3. aldosterone upregulation |
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when i have a question with
CHF, what is the FIRST THING THAT SHOULD COME TO MIND?? that it is a ____ |
LOW VOLUME STATE!!!!!!
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NO 's effects on Na regulation
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cause natriuresis and diuresis SEPARATE from vasodilatory properties
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if you lose your pituitary, will adh secretion be impaired? what about thirst
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ADH secretion = impaired
thirst mech still intact (b/c controlled by hypothal) |
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non-osmotic stimuli for ADH release
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"vp vend"
-vomiting -pain -volume depletion -exercise -narcotics -drugs |
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in states of Na conservation, can excrete as little as ____ mmol/day of Na+
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1-2 mmol/day
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in states of Na excess, can excrete as much as ___ mmol/day
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800 mmol/day
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