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13 Cards in this Set

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Fentanyl Presentation
100mcg in 2ml amp


250 mcg in 1ml glass amp or cartridge


(IN use only)

Fentanyl Pharmacology
A synthetic narcotic analgesic





Fentanyl Central Nervous System Effects / Actions

1. Depression - leading to analgesia




2. Respiratory depression - leading to apnoea




3. Dependence (addiction)

Fentanyl Cardiovascular Effects / Actions

1. Decreases conduction velocity through the A.V. node

Fentanyl Metabolism
By the Liver and excreted by the kidneys
Fentanyl Primary Emergency Indications ALS
1. CPR Interfering patient



2. Analgesia - IV / IN


- Hx of hypersensitivity or allergy to Morphine.


- Known renal impairment / failure.


- Short duration of action desirable.


- Hypotension


- Nausea and vomiting


- Severe headache

Fentanyl Primary Emergency Indications Mica

1. Sedation to facilitate intubation




2. Sedation to maintain intubation




3. Sedation to facilitate trans thoracic pacing




4. Sedation to facilitate synchronised cardioversion.

Fentanyl Contraindications
1. Known hypersensitivity


2. Late second stage of labour

Fentanyl Precautions
1. Elderly / frail patients
2. Impaired hepatic function
3. Respiratory depression, E.g COPD
4. Current asthma
5. Pts on Monoamine oxidase inhibitors
6. Known addiction to opioids.
7. Rhinitis, rhinorrhea or facial trauma (IN route)
Fentanyl Route of Administration
1. Intravenous
2. Intranasal

3. IV Infusion

Fentanyl Side Effects
1. Respiratory Depression


2. Apnoea



3. Rigidity of the diaphragm and intercostal muscles



4. Bradycardia

Fentanyl Special notes
1. Fentanyl is a Schedule 8 drug under the Poisons Act and its use must be carefully controlled. with accountability and responsiblity.


2. Respiratory depression can be refused with
Naloxone Hydrochloride.



3. 100 mcg fentanyl is equivalent in analgesic activity to 10mg morphine.

Fentanyl - Times
IV Effects:


Onset: immediate
Peak: < 5min
Duration: 30-60 min

IN effects:
Peak: 2 min