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10 Cards in this Set
- Front
- Back
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What can cause secondary dyslipidemia with increased LDL-C?
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Cyclosporine
Thiazide diuretics |
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What can cause secondary dyslipidemia with increased triglycerides?
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Excess alcohol consumption, beta-blockers, thiazide diuretics, oral contraceptives
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What can cause secondary dyslipidemia with decreased HDL-C?
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Beta-blockers
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Which statin is not metabolized by the liver?
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Pravastatin
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What is the MOA of statins?
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Inhibits HMG CoA and blocks cholesterol synthesis. Increases production of LDL receptors in the liver. Increases uptake of LDL from plasma. Decreases VLDL secretion.
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What are the adverse effects of statins?
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Elevated liver transaminases (3x normal; 0.4% to 1.9%), headaches (9%), myalgia is common (10-30%)
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Which statins are metabolized by CYP2C9?
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Fluvastatin
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Which statins are metabolized by CYP3A4?
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Atorvastatin, Cerivastatin, Lovastatin, Rosuvastatin, and Simvastatin
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What is the MOA of nicotinic acid?
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Decreases the production of VLDL (decreases TGs). Decreases LDL particle number (shifts sdLDL to large LDL). Increases circulating levels of HDL. Decreases LP(a).
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What are the adverse effects of nicotinic acid?
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Cutaneous flushing, gastritis/ulcer disease, hepatitis, acanthosis nigricans, glucose intolerance, hyperuricemia, atrial arrhythmias, and aggravation of asthma
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