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10 Cards in this Set

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What can cause secondary dyslipidemia with increased LDL-C?
Cyclosporine
Thiazide diuretics
What can cause secondary dyslipidemia with increased triglycerides?
Excess alcohol consumption, beta-blockers, thiazide diuretics, oral contraceptives
What can cause secondary dyslipidemia with decreased HDL-C?
Beta-blockers
Which statin is not metabolized by the liver?
Pravastatin
What is the MOA of statins?
Inhibits HMG CoA and blocks cholesterol synthesis. Increases production of LDL receptors in the liver. Increases uptake of LDL from plasma. Decreases VLDL secretion.
What are the adverse effects of statins?
Elevated liver transaminases (3x normal; 0.4% to 1.9%), headaches (9%), myalgia is common (10-30%)
Which statins are metabolized by CYP2C9?
Fluvastatin
Which statins are metabolized by CYP3A4?
Atorvastatin, Cerivastatin, Lovastatin, Rosuvastatin, and Simvastatin
What is the MOA of nicotinic acid?
Decreases the production of VLDL (decreases TGs). Decreases LDL particle number (shifts sdLDL to large LDL). Increases circulating levels of HDL. Decreases LP(a).
What are the adverse effects of nicotinic acid?
Cutaneous flushing, gastritis/ulcer disease, hepatitis, acanthosis nigricans, glucose intolerance, hyperuricemia, atrial arrhythmias, and aggravation of asthma