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46 Cards in this Set
- Front
- Back
- 3rd side (hint)
What kind of collagen in cartilage?
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type II
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Name the dz: macrocephaly, FGF-3 mutation, thinned growth plate but unaffected secondary centers of ossificaiton and articular cartilage?
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achondroplasia
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osteochondroma
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hamartoma of skeleton, defect in Ring of Ranvier--> protuberance
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phases of fracture healing?
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1)inflammatory phase (hemorrhage, neovascularization, callus form'n), 2)reparative phase 3) remodeling phase
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single most common form of joint disease
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osteoarthritis
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Lesch-Nyhan syndrome
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X-linked deficiency of HPRT--> mentally retarded and get gout
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4 stages of gout
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1) asymptomatic hyperuricemia 2) acute gouty arthritis 3) intercritical period 4) tophaceoous gout
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destructive vertebral lesion + extension of disease along psoas muscle, think--?
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tubercular osteomyelitis
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None
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Most likely reason for non-obese male to get boobies?
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micronodular cirrhosis (chronic EtOHism), impairs hepatic estrogen metabolism
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most common cause of spinal cord dysfuncion in >65 y/o?
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myelopathy
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Classical clinical findings of cervical myelopathy?
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loss of dexterity/coordination, impaired balance/gait
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cauda equina syndrome
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Emergency!! Get severe leg pain, saddle anesthesia, altered bladder function from a massive herniated disc/spondylolithis
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red flags for back pain
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progressive unrelenting pain, worse at night/rest, constitutional symptoms
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What nerve root and disc involved in middle finger sensation and wrist flexion?
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C7, C6-7disck
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What nerve root/disc involved in anterior tibialis movement and medial leg sensation?
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L4/L3-4
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What nerve root/disc involved in lateral foot sensation?
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S1/L5-S1
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What nerve root/disc involed in lateral arm sensation?
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C5/C4-5
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Classic triad of Sjogren's?
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dry eyes, dry mouth, arthritis
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None
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Most frequently involved visceral organ in SSc?
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GIT
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Leading cause of morbidity and mortality in SSc?
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lung involvement (pulmonary fibrosis--diffuse; pulmonary HTN--limited)
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"watermelon stomach" seen in?
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SSc
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most deadly complication of SSc?
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renal involvement--scleroderma renal crisis
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What is scleroderma renal crisis?
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most deadly complication of SSc; malignant HTN w/HA and retinopathy, acute cardiac failure, MI, stroke, oliguria with rapidly progressive renal insufficiency
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"salt and pepper" skin seen ?
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SSc
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3 characteristic features responsible for clinicopatho manifestations of SSc?
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1)excessive collagen dep in skin and viscera 2) vascular lesions of capillaries and sm arteries 3) alterations of humoral and cellular immunity
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lab findings diffuse (D) vs limited (L) SSc?
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D--speckled/nucleolar IF, scl-70/anti-topoisomerase +; L--centromere IF, anti-centromere/anti-kinetochore +
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Arthritis in SSc?
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symmetric polyarthralgia in early SSc but true arthritis and synovitis are rare
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isolated reduction in DLCO in SSc means?
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pulmonary HTN (probably limited SSc)
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Cardiac manifestations in SSc?
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clinically significant primary dysfunction rare but tachyarrythmias and conduction disturbances common
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meralgia paresthetica
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intermittent burning pain, numbness of anterolateral thigh; lateral femoral cutaneous nerve compression
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meralgia paresthetica commonly seen in what populations?
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diabetics, preggers, obesers
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Name the dz and tx: trigger points that give rise to characteristic referred pain?
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dz: regional myofascial pain; tx: capsaicin
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Name the dz and tx: widespread pain and fatigue and 11/18 tender points
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dz: fibromyalgia; tx: TCA, gabapentin, education
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5 diagnostic critera of Giant Cell arteritis
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1) >50y/o 2) new HA 3) temporal artery abnl 4) elevated ESR (>50) 5) abnl artery bx with mononuclear cell infiltrate, granulomatous inflammaiton, giant cells
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6 diagnostic criteria of Takayasu arteritis
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1) <40 y/o 2) claudicaiton of extremities 3) dec'd brachial artery pulse 4) BP difference >10mmHg b/t arms 5) bruit over subclavian/aorta 6) arteriogram abnl
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What arteritis has patchy distribution and propensity for mesenteric aneurysm formation?
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polyarteritis nodosa
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"strawberry tongue" seen in what arteritis?
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Kawasaki dz (a necrotizing vasculitis)
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types of mixed cryoglobulinemia
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1) monoclonal Igs (MM, Waldenstrom's) 2) essential mixed (polyclonal IgG and monoclonal RF) 3) mixed polyclonal
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hep C most frequently associated with what type mixed cryoglobulinemia?
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essential mixed
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Henoch-Schonlein purpura clinical tetrad:
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1) purpura 2) arthritis 3) ab pain 4) glomerulonephritis
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Diagnostic criteria for Wegener's
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1) nasal or oral inflamm 2) abnl CXR 3) urinary sediment 4) granulomatous inflamm on bx
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Jo-1 Ab assoc'd with?
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myositis
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11 diagnostic criteria for SLE
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1. Malar rash 2. Discoid rash 3. Photosensitivity 4. Oral/nasoph. Ulcers 5. Arthritis 6. Serositis 7. Renal d/o 8. Neuro 9. Hematologic 10 immunologic 11. ANA
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major cause of death in SLE?
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increased atherosclerotic HD
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mucocutaneous manifestations of SLE?
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mucosal ulcers (usually painless), malar rash (sparing of nasolabial folds), alopecia, palpable purpura
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who gets SLE?
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young black women (mostly)
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