Fatty Acids=General Lecture 60

Front 1

Hormonal Regulation of Glycogen Metabolism

Back 1

insert pic. lecture 59 pg 16

Front 2

Reciprocal Regulation of carbohydrate metabolism

Back 2

insert. pic. lect. 59 pg 17

Front 3

Families of lipoprotein particles

Back 3

1=cholimicrons, tag b-48, leave intestine and extrahepatic tissue and remove some fat
2=VLDL, IDL, LDL, tag H 100, move from less dense to more dense on path
3=HDL aquires cholesterol and returns to liver

Front 4

Lipid transport

Back 4

insert pic. leture 60 p. 3

Front 5

Lipases
types

Back 5

Pancreatic Lipase=works on dietary lipids
Lipoprotein Lipase=works on circulating liptrotein Particles
HSL= works to release TAG stored in adipocytes

Front 6

Structure of Lipoprotein particle

Back 6

1=unesterified cholesterol
2=phospholipid monolayer
3=Cholesteryl ester
4=Apoprotein B tag for address

Front 7

VLDLs—

Back 7

liver packages FA’s into VLDLs, puts address tag B-100 on, and sends out into circulation; pass thru extrahepatic tissue (mammary, muscle, adipose) and are liberated by lipoprotein lipase into FFAs and cells take up
--wind up with IDLs and LDLs—these also return to liver

Front 8

HDLs—

Back 8

leave liver, pass thru extrahepatic tissue, acquire cholesterol, and transport cholesterol back to liver

Front 9

Chylomicrons

Back 9

Chylomicrons---apolipoprotein B-48, dietary fats are taken up by small intestine, packaged in chylomicrons → pass thru mammary, muscle, or adipose tissue → lipoprotein lipase liberates these FA molecules from the inside, allows these tissues to take up free fatty acids → chylomicron remnants come out and are delivered to liver

Front 10

Hormonal regulation of release of fatty acids to blood

Back 10

1=hormone binds, epinephrine
2=G protein cascade to Protein Kinase A
3=PKA pi perilipin on shell of lipoprotein particle
4=make it easier for PKA to then pi Hormone Sensitive Lipase (HSL) which releases fatty acids into the blood

Front 11

Exta Hepatic Tissue

Path of travel of lipoprotein

Back 11

Extra Hepatic=muscle, mmamary glands, adipose tissue

path=intestines to liver in form of cholimicron, from liver to blood stream and return from cappilary of extrahepatic tissue with extra lipid load to liver, repeat

Front 12

Good vs. Bad cholesterol

Back 12

depends
important for developmental signalling
HDL= good to bring from periphery to liver
LDL=bad in blood vessel, plaques

Front 13

Lipase Activity

Back 13

Lipase catalyzes a hydrolysis across the double carbonyl bond in the acyly part of the tri acyl glyerol
leaves glycerol and 3 fatty acids

Front 14

Movement of Free Fatty Acids in Blood

Back 14

travel with serum albumin in blood stream