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14 Cards in this Set

  • Front
  • Back
Hormonal Regulation of Glycogen Metabolism
insert pic. lecture 59 pg 16
Reciprocal Regulation of carbohydrate metabolism
insert. pic. lect. 59 pg 17
Families of lipoprotein particles
1=cholimicrons, tag b-48, leave intestine and extrahepatic tissue and remove some fat
2=VLDL, IDL, LDL, tag H 100, move from less dense to more dense on path
3=HDL aquires cholesterol and returns to liver
Lipid transport
insert pic. leture 60 p. 3
Pancreatic Lipase=works on dietary lipids
Lipoprotein Lipase=works on circulating liptrotein Particles
HSL= works to release TAG stored in adipocytes
Structure of Lipoprotein particle
1=unesterified cholesterol
2=phospholipid monolayer
3=Cholesteryl ester
4=Apoprotein B tag for address
liver packages FA’s into VLDLs, puts address tag B-100 on, and sends out into circulation; pass thru extrahepatic tissue (mammary, muscle, adipose) and are liberated by lipoprotein lipase into FFAs and cells take up
--wind up with IDLs and LDLs—these also return to liver
leave liver, pass thru extrahepatic tissue, acquire cholesterol, and transport cholesterol back to liver
Chylomicrons---apolipoprotein B-48, dietary fats are taken up by small intestine, packaged in chylomicrons → pass thru mammary, muscle, or adipose tissue → lipoprotein lipase liberates these FA molecules from the inside, allows these tissues to take up free fatty acids → chylomicron remnants come out and are delivered to liver
Hormonal regulation of release of fatty acids to blood
1=hormone binds, epinephrine
2=G protein cascade to Protein Kinase A
3=PKA pi perilipin on shell of lipoprotein particle
4=make it easier for PKA to then pi Hormone Sensitive Lipase (HSL) which releases fatty acids into the blood
Exta Hepatic Tissue

Path of travel of lipoprotein
Extra Hepatic=muscle, mmamary glands, adipose tissue

path=intestines to liver in form of cholimicron, from liver to blood stream and return from cappilary of extrahepatic tissue with extra lipid load to liver, repeat
Good vs. Bad cholesterol
important for developmental signalling
HDL= good to bring from periphery to liver
LDL=bad in blood vessel, plaques
Lipase Activity
Lipase catalyzes a hydrolysis across the double carbonyl bond in the acyly part of the tri acyl glyerol
leaves glycerol and 3 fatty acids
Movement of Free Fatty Acids in Blood
travel with serum albumin in blood stream