Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
24 Cards in this Set
- Front
- Back
|
relative risk ratio eqn |
risk of disease in relatives of type R/risk of disease in general population |
|
|
what is the cut off for a RRR |
anything greater than 1 suggests a familial component |
|
|
RRR is a measure of the strength of |
familial aggregation |
|
|
pairwise concordance equation |
# both affected / # both affected + # one affected |
|
|
what is an example of a complex disease with regard to twin concordance |
early-onset parkinsons has much higher concordance amongst MZs than late-onset parkinsons |
|
|
a parent-offspring regression can be used to measure |
hertability |
|
|
how many mating types will there be with a bi-allelic locus? |
6 |
|
|
equation for segregation ratio |
affected offspring/total offspring |
|
|
use segregation analysis to look for |
major gene or inheritance pattern |
|
|
linkage analysis is generally done after what other kind of analysis |
segregation analysis |
|
|
CF was originally tracked using what |
paraoxinase activity |
|
|
with linkage do you have an excess of recombinants or non-recombs |
non-recombs |
|
|
what is the null hypothesis in linkage analysis |
no linkage (0.5) |
|
|
what is the "odds" in a LOD score |
odds of linkage/odds of no linkage |
|
|
what often make good markers for linkage and why |
STRs because they are highly polymorphic/heterozygous in a population |
|
|
what is used to find predisposing alleles to complex conditions |
genetic association |
|
|
haplotypes are blocks of genomic DNA in (high/low) linkage disequilibrium |
high |
|
|
what is "hypothesis free" |
GWAS |
|
|
what is an example of a GWAS success story |
AMD |
|
|
You can map disease variants using (2) |
linkage analysis and genetic association |
|
|
in a manhatten plot, a higher peak indicates a |
lower p value (implying association) |
|
|
why is odds ratio especially useful |
don't need to know true prevalence of the disease |
|
|
odds ratio: for qualitative or quantitative? |
qualitative? |
|
|
comparing mean trait levels among different genotypes is looking at quantitative or qualitative? |
quantitative |
