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206 Cards in this Set
- Front
- Back
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man presents with squamous cell carcinoma of the penis- exposure to what virus
|
HPV
|
|
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man presents with squamous cell carcinoma of the penis- exposure to what virus
|
HPV
|
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college student presents with lymphadenopathy, fever, and hepatosplenomegaly- serum agglutinates sheep RBCs
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B cell (EBV- infectious mono)
|
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Herpesviruses genome
|
DS DNA linear enveloped
|
|
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hepadnavirus genome
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DS -DNA partial circular enveloped
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|
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adenovirus genome
|
DS DNA linear nonenveloped
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parvovirus genome
|
SS DNA linear nonenveloped (only SS DNA virus) smallest
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papillomavirus genome
|
DS DNA circular nonenveloped
|
|
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polyomavirus genome
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DS DNA circular nonenveloped
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poxvirus genome
|
DS DNA linear (largest) enveloped
|
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DNA virus families:
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HHAPPPy viruses : hepadna, herpes, adeno, pox, parvo papilloma, polyoma yeah!
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|
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all DNA viruses are icosahedral except ____ viruses
|
pox
|
|
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important viruses in family herpesviruses
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HSV 1,2,6,8 VZV, CMV,EBV (DS DNA linear enveloped)
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|
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important viruses in hepadnavirus family
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HBV (DS -DNA partial circular enveloped)
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important virus in parvovirus family
|
B19 (SS DNA linear nonenveloped (only SS DNA virus) smallest)
|
|
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important virus in polyomavirus family
|
JC (DS DNA circular nonenveloped)
|
|
|
all DNA viruses replicate in the nucleus except ____ viruses
|
pox
|
|
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picornavirus genome
|
SS + RNA linear non-enveloped icosahedral
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|
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calicivirus genome
|
SS + RNA linear non-enveloped icosahedral
|
|
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reovirus genome
|
DS + RNA 10-12 segments linear non-enveloped icosahedral
|
|
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flavivirus genome
|
SS + RNA linear enveloped icosahedral
|
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togavirus genome
|
SS + RNA linear enveloped icosahedral
|
|
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retrovirus genome
|
SS + RNA linear enveloped icosahedral
|
|
|
coronavirus genome
|
SS + RNA linear enveloped helical
|
|
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orthyomyxovirus genome
|
SS - RNA linear 8 segments enveloped helical
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|
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paramyxovirus genome
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SS - RNA linear nonsegmented enveloped helical
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|
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rhabdovirus genome
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SS - RNA linear enveloped helical
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|
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filovirus genome
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SS - RNA linear enveloped helical
|
|
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arenavirus genome
|
SS - RNA circular enveloped helical
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bunyavirus genome
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SS - RNA circular 3 segments enveloped helical
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|
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deltavirus genome
|
SS - RNA circular enveloped helical
|
|
|
important picornaviruses
|
PERCH- polio, echo, rhino, coxsacki, HAV
|
|
|
important calici - now hepeviridae
|
HEV
|
|
|
important reoviruses
|
reovirus, rotavirus
|
|
|
important flaviviruses
|
HCV, yellow fever, dengue, St. Luis, West Nile
|
|
|
important togaviruses
|
Rubella, eastern equine encephalitis, western equine encephalitis
|
|
|
important retroviruses
|
HIV, HTLV
|
|
|
important coronaviruses
|
coronavirus, SARS
|
|
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important orthomyxoviruses
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influenzae
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|
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important paramyxoviruses
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parainfluenza, RSV, rubeola, mumps
|
|
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important rhabdoviruse
|
rabies
|
|
|
important filoviruses
|
ebola, marburg, hemorrhagic fevor
|
|
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important arenaviruses
|
LCV, lassa fever
|
|
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important bunyaviruses
|
cali encephalitis, hantavirus
|
|
|
important delta virus
|
HDV
|
|
|
all RNA viruses except ____ are ssRNA
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reoviruses
|
|
|
all DNA viruses except _____are ds DNA
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parvoviruses
|
|
|
herpesviruses acquire their envelope from the ______
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nuclear membrane
|
|
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non-enveloped viruses include:
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Naked CPR and PAPP - naked= calicivirius, picornavirus, reovirus, parvo, adeno, papillo, polyoma viruses
|
|
|
the only viral family that is diploid (2 copies) is the _______
|
herpesviruses
|
|
|
all RNA viruses replicate in the cytoplasm, except ____ and ____
|
influenza, retroviruses
|
|
|
MMR, sabin polio, VZV, yellow fever, and smallpox vaccines are all ______
|
live attenuated
|
|
|
Rabies, influenza, Salk polio, and HAV vaccines are all _____
|
killed
|
|
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the only recombinant viral protein used is _____
|
HBV (HBsAg)
|
|
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negative stranded viruses most transcribe to postive strand using ______: what are the viruses?
|
RNA polymerase, Always Bring Polymerase Or Fail Replication Horribly, arena, bunya, paramyxo, orthomyxo, filo, rhabdo, hepatitis delta virus
|
|
|
segmented viruses:
|
BOAR bunya, orthomyxo, arena, reo (all are RNA)
|
|
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gingivostmatitis, keratoconjunctivitis, temporla lobe encephalopathy, herpes labialis
|
HSV-1
|
|
|
cause of herpes genitalis, neonatal herpes
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HSV-2
|
|
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shingles, encephalitis, pneumonia
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VZV
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|
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infectious mononucleolis, burkitt's lymphoma
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EBV
|
|
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congenital infection, mono (negative monospot), pneumonia, owl eyes
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CMV
|
|
|
Kaposi sarcoma virus
|
HHV-8
|
|
|
mode of transmission of HSV-1
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saliva, resp secretions
|
|
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mode of transmission of HSV-2
|
sexual contact, perianal
|
|
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mode of transmission of EBV
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respiratory secretions
|
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mode of transmission of VZV
|
respiratory secretions
|
|
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mode of transmission of CMV
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congenital, transfusion, sexual contact, saliva, transplant
|
|
|
mode of transmission of HH-8
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sexual contact
|
|
|
tzank test used to idenify
|
HSV-1, HSV-2, VZV- infected cells also have intranuclear Cowdy A inclusions
|
|
|
positive heterophile antibody test (monospot against sheep RBCs)
|
EBV
|
|
|
abnormal circulating cytotoxic T cells (atypical lymphocytes) can indicate infection with
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EBV
|
|
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what are the picornaviruses and how are they replicated
|
polio, echo, rhino, coxsacki, HAV- RNA translated into 1 large peptide that is cleaved. SS RNA +
|
|
|
what family is rhinovirus and is it enveloped or nonenveloped
|
rhino= picorna = noneveloped
|
|
|
yellow fever virus is a ______ transmitted by the ______. The virus has a monkey or human resevoir.
|
flavi, aedes
|
|
|
high fever, black vomitus, and jaundice- councilman bodies (acidophilic inclusions) in liver cells
|
yellow fever virus
|
|
|
fever, lymphadenopathy, arthralgia, fine truncal rash. Mild in children but serious congenital infection.
|
rubella (togavirus) TORCH (german 3 day measles)
|
|
|
most important global cause of infantile gastronteritis
|
rotavirus (right out the anus)- a reovirus
|
|
|
major cause of acute viral diarrhea in the US during winter months- villous destruction with atrophy
|
rotavirus (right out the anus)- a reovirus
|
|
|
describe influenza's genome
|
orthomyxovirus- enveloped, SS RNA with segmented genome. Contains hemagglutinin and neuraminidase antigens
|
|
|
reasortment of viral genome (as in human flu A recombines with pig flu A)
|
genetic shift
|
|
|
minor antigenic changes based on mutation
|
genetic drift
|
|
|
current treatment for influenza
|
zanamivir and oseltamivir (both neuraminidase inhibitors) work for influenza A and B
|
|
|
what class of drugs for treating influenza no longer work because of resistance
|
amantidine and rimantidine (block viral penetration/uncoating)
|
|
|
influenza vaccin is a ____ vaccine
|
killed
|
|
|
paramyxoviruses cause diseas in _____ and include
|
parainfluenza (croup), mumps, measles, RSV
|
|
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koplik spots
|
rubeola (measles)
|
|
|
3 C's of measles (rubeola)
|
cough, coryza, conjunctivitis (in Koplik spots) rash from head to toes
|
|
|
sequella of measles
|
SSPE, giant cell pneumonia in immunosuppressed
|
|
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mumps is a _____ virus that has symptoms of _______, ________, and _______.
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POM- parotitis, orchitis, meningitis (aseptic)
|
|
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fatal encephalitis with seizures, hydrophobia, hypersalivation, and pharyngeal spasm.
|
rabies
|
|
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hepatitis virus that is a picorna virus
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A
|
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hepatitis virus that is a hepadnavirus
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B
|
|
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hepatitis virus that is a RNA virus
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C
|
|
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hepatitis virus that is a delta virus
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D
|
|
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hepatitis virus that is a hepevirus (calici)
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E
|
|
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hepatitis viruses transmitted by fecal oral
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A, E
|
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hepatitis viruses transmitted by parenteral, sexual, and maternal-fetal
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B
|
|
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hepatitis viruses transmitted by blood primarily
|
C
|
|
|
describe replication of HBV
|
cellular RNA polymerase transcribes RNA from DNA template, RT transcribes DNA genome from RNA intermediate. Virion enzyme is a DNA-dependent DNA polymerase
|
|
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hepatitis among IV drug users
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C
|
|
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hepatitis with high mortality in pregnant women
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E
|
|
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needs coinfection with hep B
|
D
|
|
|
immunity ab to HBV
|
HBsAg
|
|
|
HBsAg, HBsAB, HBcAb status during acute infection
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+ - + (IgM)
|
|
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HBsAg, HBsAB, HBcAb status during window phase
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- - +
|
|
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HBsAg, HBsAB, HBcAb status during chronic carrier
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+ - + (IgG)
|
|
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HBsAg, HBsAB, HBcAb status during complete recovery
|
+ - + (IgG)
|
|
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HBsAg, HBsAB, HBcAb status during immunized
|
- + -
|
|
|
gp41 and gp120 are ______ proteins on HIV
|
envelope
|
|
|
describe replication of HIV
|
RT synthesizes dsDNA from RNA, integrates into host genome
|
|
|
HIV virus binds what 2 molecules?
|
CXCR4, CCR5 and CD4
|
|
|
AIDs diagnosis with CD4 count _______, HIV with AIDS indicator condition (ie PCP), or CD4/CD8 ratio _____
|
below 200, less than 1.5
|
|
|
opportunistic infections in the brain with aids:
|
cryptococcal meningitis, toxo, CMV encephalopathy, AIDs dementia, PML (JC virus)
|
|
|
opportunistic infections in the eyes with aids:
|
CMV retinitis
|
|
|
opportunistic infections in the mouth and throat with aids:
|
thrush, HSV, CMV, oral hairy leukoplakia (EBV)
|
|
|
man presents with squamous cell carcinoma of the penis- exposure to what virus
|
HPV
|
|
|
college student presents with lymphadenopathy, fever, and hepatosplenomegaly- serum agglutinates sheep RBCs
|
B cell (EBV- infectious mono)
|
|
|
Herpesviruses genome
|
DS DNA linear enveloped
|
|
|
hepadnavirus genome
|
DS -DNA partial circular enveloped
|
|
|
adenovirus genome
|
DS DNA linear nonenveloped
|
|
|
parvovirus genome
|
SS DNA linear nonenveloped (only SS DNA virus) smallest
|
|
|
papillomavirus genome
|
DS DNA circular nonenveloped
|
|
|
polyomavirus genome
|
DS DNA circular nonenveloped
|
|
|
poxvirus genome
|
DS DNA linear (largest) enveloped
|
|
|
DNA virus families:
|
HHAPPPy viruses : hepadna, herpes, adeno, pox, parvo papilloma, polyoma yeah!
|
|
|
all DNA viruses are icosahedral except ____ viruses
|
pox
|
|
|
important viruses in family herpesviruses
|
HSV 1,2,6,8 VZV, CMV,EBV (DS DNA linear enveloped)
|
|
|
important viruses in hepadnavirus family
|
HBV (DS -DNA partial circular enveloped)
|
|
|
important virus in parvovirus family
|
B19 (SS DNA linear nonenveloped (only SS DNA virus) smallest)
|
|
|
important virus in polyomavirus family
|
JC (DS DNA circular nonenveloped)
|
|
|
all DNA viruses replicate in the nucleus except ____ viruses
|
pox
|
|
|
picornavirus genome
|
SS + RNA linear non-enveloped icosahedral
|
|
|
calicivirus genome
|
SS + RNA linear non-enveloped icosahedral
|
|
|
reovirus genome
|
DS + RNA 10-12 segments linear non-enveloped icosahedral
|
|
|
flavivirus genome
|
SS + RNA linear enveloped icosahedral
|
|
|
togavirus genome
|
SS + RNA linear enveloped icosahedral
|
|
|
retrovirus genome
|
SS + RNA linear enveloped icosahedral
|
|
|
coronavirus genome
|
SS + RNA linear enveloped helical
|
|
|
orthyomyxovirus genome
|
SS - RNA linear 8 segments enveloped helical
|
|
|
paramyxovirus genome
|
SS - RNA linear nonsegmented enveloped helical
|
|
|
rhabdovirus genome
|
SS - RNA linear enveloped helical
|
|
|
filovirus genome
|
SS - RNA linear enveloped helical
|
|
|
arenavirus genome
|
SS - RNA circular enveloped helical
|
|
|
bunyavirus genome
|
SS - RNA circular 3 segments enveloped helical
|
|
|
deltavirus genome
|
SS - RNA circular enveloped helical
|
|
|
important picornaviruses
|
PERCH- polio, echo, rhino, coxsacki, HAV
|
|
|
important calici - now hepeviridae
|
HEV
|
|
|
important reoviruses
|
reovirus, rotavirus
|
|
|
important flaviviruses
|
HCV, yellow fever, dengue, St. Luis, West Nile
|
|
|
important togaviruses
|
Rubella, eastern equine encephalitis, western equine encephalitis
|
|
|
important retroviruses
|
HIV, HTLV
|
|
|
important coronaviruses
|
coronavirus, SARS
|
|
|
important orthomyxoviruses
|
influenzae
|
|
|
important paramyxoviruses
|
parainfluenza, RSV, rubeola, mumps
|
|
|
important rhabdoviruse
|
rabies
|
|
|
important filoviruses
|
ebola, marburg, hemorrhagic fevor
|
|
|
important arenaviruses
|
LCV, lassa fever
|
|
|
important bunyaviruses
|
cali encephalitis, hantavirus
|
|
|
important delta virus
|
HDV
|
|
|
all RNA viruses except ____ are ssRNA
|
reoviruses
|
|
|
all DNA viruses except _____are ds DNA
|
parvoviruses
|
|
|
herpesviruses acquire their envelope from the ______
|
nuclear membrane
|
|
|
non-enveloped viruses include:
|
Naked CPR and PAPP - naked= calicivirius, picornavirus, reovirus, parvo, adeno, papillo, polyoma viruses
|
|
|
the only viral family that is diploid (2 copies) is the _______
|
herpesviruses
|
|
|
all RNA viruses replicate in the cytoplasm, except ____ and ____
|
influenza, retroviruses
|
|
|
MMR, sabin polio, VZV, yellow fever, and smallpox vaccines are all ______
|
live attenuated
|
|
|
Rabies, influenza, Salk polio, and HAV vaccines are all _____
|
killed
|
|
|
the only recombinant viral protein used is _____
|
HBV (HBsAg)
|
|
|
negative stranded viruses most transcribe to postive strand using ______: what are the viruses?
|
RNA polymerase, Always Bring Polymerase Or Fail Replication Horribly, arena, bunya, paramyxo, orthomyxo, filo, rhabdo, hepatitis delta virus
|
|
|
segmented viruses:
|
BOAR bunya, orthomyxo, arena, reo (all are RNA)
|
|
|
gingivostmatitis, keratoconjunctivitis, temporla lobe encephalopathy, herpes labialis
|
HSV-1
|
|
|
cause of herpes genitalis, neonatal herpes
|
HSV-2
|
|
|
shingles, encephalitis, pneumonia
|
VZV
|
|
|
infectious mononucleolis, burkitt's lymphoma
|
EBV
|
|
|
congenital infection, mono (negative monospot), pneumonia, owl eyes
|
CMV
|
|
|
Kaposi sarcoma virus
|
HHV-8
|
|
|
mode of transmission of HSV-1
|
saliva, resp secretions
|
|
|
mode of transmission of HSV-2
|
sexual contact, perianal
|
|
|
mode of transmission of EBV
|
respiratory secretions
|
|
|
mode of transmission of VZV
|
respiratory secretions
|
|
|
mode of transmission of CMV
|
congenital, transfusion, sexual contact, saliva, transplant
|
|
|
mode of transmission of HH-8
|
sexual contact
|
|
|
tzank test used to idenify
|
HSV-1, HSV-2, VZV- infected cells also have intranuclear Cowdy A inclusions
|
|
|
positive heterophile antibody test (monospot against sheep RBCs)
|
EBV
|
|
|
abnormal circulating cytotoxic T cells (atypical lymphocytes) can indicate infection with
|
EBV
|
|
|
what are the picornaviruses and how are they replicated
|
polio, echo, rhino, coxsacki, HAV- RNA translated into 1 large peptide that is cleaved. SS RNA +
|
|
|
what family is rhinovirus and is it enveloped or nonenveloped
|
rhino= picorna = noneveloped
|
|
|
yellow fever virus is a ______ transmitted by the ______. The virus has a monkey or human resevoir.
|
flavi, aedes
|
|
|
high fever, black vomitus, and jaundice- councilman bodies (acidophilic inclusions) in liver cells
|
yellow fever virus
|
|
|
fever, lymphadenopathy, arthralgia, fine truncal rash. Mild in children but serious congenital infection.
|
rubella (togavirus) TORCH (german 3 day measles)
|
|
|
most important global cause of infantile gastronteritis
|
rotavirus (right out the anus)- a reovirus
|
|
|
major cause of acute viral diarrhea in the US during winter months- villous destruction with atrophy
|
rotavirus (right out the anus)- a reovirus
|
|
|
describe influenza's genome
|
orthomyxovirus- enveloped, SS RNA with segmented genome. Contains hemagglutinin and neuraminidase antigens
|
|
|
reasortment of viral genome (as in human flu A recombines with pig flu A)
|
genetic shift
|
|
|
minor antigenic changes based on mutation
|
genetic drift
|
|
|
current treatment for influenza
|
zanamivir and oseltamivir (both neuraminidase inhibitors) work for influenza A and B
|
|
|
what class of drugs for treating influenza no longer work because of resistance
|
amantidine and rimantidine (block viral penetration/uncoating)
|
|
|
influenza vaccin is a ____ vaccine
|
killed
|
|
|
paramyxoviruses cause diseas in _____ and include
|
parainfluenza (croup), mumps, measles, RSV
|
|
|
koplik spots
|
rubeola (measles)
|
|
|
3 C's of measles (rubeola)
|
cough, coryza, conjunctivitis (in Koplik spots) rash from head to toes
|
|
|
sequella of measles
|
SSPE, giant cell pneumonia in immunosuppressed
|
|
|
mumps is a _____ virus that has symptoms of _______, ________, and _______.
|
POM- parotitis, orchitis, meningitis (aseptic)
|
|
|
fatal encephalitis with seizures, hydrophobia, hypersalivation, and pharyngeal spasm.
|
rabies
|
|
|
erythema infectiosum (fifth's disease) is caused by
|
parvovirus B19- adults get arthralgias and arthritis mimicing rhuematoid arthritis. children get slapped cheeks
|
|
|
aplastic crisis in sickle cell related to what virus
|
parvo B19
|
