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27 Cards in this Set

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Finasteride:

Mechanism of action?
5-alpha reductase inhibitor
(decr conversion of testosterone to DHT)
Finasteride:

Clinical use?
-BPH
-male pattern baldness (also promotes hair growth)
Flutamide:

Mech of action?
Nonsteroidal competitive inhibitor of androgens at testosterone receptor
Flutamide:

Clinical use?
Prostate cancer
What drug is used to treat benign prostatic hypertrophy?
Finasteride
What drugs can be used to prevent hirsutism polycystic ovarian syndrome, and what is their MOA?
Ketoconazole, spironolactone.

Inhibit steroid synthesis.
What drugs may treat erectile dysfuction?
Sildenafil, Vardenafil
What is the MOA of Sildenafil and Vardenafil?
Inhibit cGMP phosphodiesterase.
Increased cGMP --> smooth muscle relaxation in corpus cavernosum.
What are the toxicities of Sildenafil and Vardenafil?
-Headache
-flushing
-dyspepsia
-blue-green color vision
When is sildenafil and vardenafil contraindicated?
When pt is taking nitrates. Risk of life-threatening hypotension.
What 2 drugs may treat prostate cancer?
Flutamide and Leuprolide (adminstered continuously)
What kind of drug is Leuprolide and how must it be administered to treat infertility?
GnRH analog.

Adminstered in pulsatile fashion.
How can leuprolide be used to treat prostate cancer?
Coadminstered in continuous fashion with flutamide (a nonsteroidal competitive inhibitor of androgens)
What drug may treat uterine fibroids?
Leuprolide
What 2 drugs may treat infertility?
-Leuprolide (pulsatile)
-Clomiphene
How does Clomiphene treat infertility?
Acts as a partial agonist at estrogen receptors in the pituitary gland. Inhibits normal feedback inhibition by estrogen and increases LH & FSH release, which stimulates ovulation
What toxicities are associated with Clomiphene?
- multiple simultaneous pregnancies
- ovarian enlargement
- visual disturbances
- hot flashes
What is the MOA and clinical use of Mifepristone?
(RU-486)

- Progesterone antagonist
- Abortifacient; prevents implantations by interfering with the action of progesterone on the endometrium.
What happens to the incidence of ectopic pregnancies with oral contraceptives?
Decreases (advantage)
What happens to the incidence of pelvic infections with oral contraceptives?
Decreases (advantage)
How do oral contraceptives affect menses?
Regulates it (advantage)
How often must oral contraceptives be taken?
Daily (disadvantage)
What happens to the risk of EMal and ovarian cancers with oral contraceptives?
Decreases (advantage)
How reliable are oral contraceptives?
Very. (< 1% failure)
How can oral contraceptives affect your coagulability?
Hypercoagulable state
How do oral contraceptives affect triglyceride levels?
Increases (disadvantage)
Do oral contraceptives provide protection against STDs?
No (disadvantage)