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27 Cards in this Set
- Front
- Back
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Finasteride:
Mechanism of action? |
5-alpha reductase inhibitor
(decr conversion of testosterone to DHT) |
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Finasteride:
Clinical use? |
-BPH
-male pattern baldness (also promotes hair growth) |
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Flutamide:
Mech of action? |
Nonsteroidal competitive inhibitor of androgens at testosterone receptor
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Flutamide:
Clinical use? |
Prostate cancer
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What drug is used to treat benign prostatic hypertrophy?
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Finasteride
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What drugs can be used to prevent hirsutism polycystic ovarian syndrome, and what is their MOA?
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Ketoconazole, spironolactone.
Inhibit steroid synthesis. |
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What drugs may treat erectile dysfuction?
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Sildenafil, Vardenafil
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What is the MOA of Sildenafil and Vardenafil?
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Inhibit cGMP phosphodiesterase.
Increased cGMP --> smooth muscle relaxation in corpus cavernosum. |
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What are the toxicities of Sildenafil and Vardenafil?
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-Headache
-flushing -dyspepsia -blue-green color vision |
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When is sildenafil and vardenafil contraindicated?
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When pt is taking nitrates. Risk of life-threatening hypotension.
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What 2 drugs may treat prostate cancer?
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Flutamide and Leuprolide (adminstered continuously)
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What kind of drug is Leuprolide and how must it be administered to treat infertility?
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GnRH analog.
Adminstered in pulsatile fashion. |
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How can leuprolide be used to treat prostate cancer?
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Coadminstered in continuous fashion with flutamide (a nonsteroidal competitive inhibitor of androgens)
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What drug may treat uterine fibroids?
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Leuprolide
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What 2 drugs may treat infertility?
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-Leuprolide (pulsatile)
-Clomiphene |
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How does Clomiphene treat infertility?
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Acts as a partial agonist at estrogen receptors in the pituitary gland. Inhibits normal feedback inhibition by estrogen and increases LH & FSH release, which stimulates ovulation
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What toxicities are associated with Clomiphene?
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- multiple simultaneous pregnancies
- ovarian enlargement - visual disturbances - hot flashes |
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What is the MOA and clinical use of Mifepristone?
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(RU-486)
- Progesterone antagonist - Abortifacient; prevents implantations by interfering with the action of progesterone on the endometrium. |
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What happens to the incidence of ectopic pregnancies with oral contraceptives?
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Decreases (advantage)
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What happens to the incidence of pelvic infections with oral contraceptives?
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Decreases (advantage)
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How do oral contraceptives affect menses?
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Regulates it (advantage)
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How often must oral contraceptives be taken?
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Daily (disadvantage)
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What happens to the risk of EMal and ovarian cancers with oral contraceptives?
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Decreases (advantage)
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How reliable are oral contraceptives?
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Very. (< 1% failure)
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How can oral contraceptives affect your coagulability?
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Hypercoagulable state
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How do oral contraceptives affect triglyceride levels?
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Increases (disadvantage)
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Do oral contraceptives provide protection against STDs?
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No (disadvantage)
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