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19 Cards in this Set
- Front
- Back
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Anti-GBM antibodies on immunofluorescence
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Goodpasture syndrome
- Type II hypersensitivity - A type of rapidly progressive GNf |
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Kimmelstiel-Wilson lesions on light microscopy
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Nodular glomerulosclerosis associated with Diabetic GN
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"Spike and dome" appearance on electron microscope
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Membranous Glomerulonephritis
(Diffuse membranous glomerulonephropathy) Accompanied by subepithelial deposits |
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"Tram tracking" of subendothelial humps on electron microscope
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Membranoproliferative Glomerulonephritis
Tram tracking appearance d/t GBM splitting caused by mesangial ingrowth |
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Subepithelial humps on electron microscope
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Acute post-strep GN
Humps d/t immune complex deposits |
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RBC casts
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Glomerulonephritis, ischemia, malignant HTN
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Differences between Type 1, Type 2, and Type 4 RTA
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Type 1 ("distal"): Defect in CT's ability to excrete H (urine pH > 5.3)
- A/w hypokalemia and calcium kidney stones Type 2 ("proximal"): PCT can't reabsorb HCO3 - A/w kypokalemia and hypo-PO4 rickets Type 4 ("hyperkalemic"): D/t hypoaldosteronism or ↓ CT response to aldosterone - A/w hyperkalemia, inhibition of ammonium secretiion - ↓ urine pH d/t ↓ buffering ability |
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WBC casts
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Acute pyelonephritis, transplant rejection
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Granular "muddy brown" casts
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ATN
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Waxy casts
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Urinary stasis d/t advanced CKD
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Child with subendothelial humps on EM and granular appearance on IF
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Acute Post-strep GN
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Crescents make of fibrin and plasma proteins on LM and IF
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Rapidly progressive (crescentic) GN
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3 types of RPGN
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1) Goodpastures
- Type II hypersentivity - anti-GBM Ab - No URT involvement - liner IF 2) Wegener's syndrome - c-ANCA - URT involvement 3) Microscopic polyangitis - p-ANCA |
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IC deposited in mesangium/expansion of mesangial matrix on LM and IF. Increased IgA synthesis
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Berger's disease (IgA nephropathy)
- A/w Henoch-Schoen purpura |
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Mutation in type IV collagen. Split basement membrane
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Alport's syndrome
- Also with visual and auditory deficits |
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SLE's nephrotic presentation
Also, the most common adult nephrotic syndrome |
Membranous GN (aka diffuse membranous GN)
- "spike and dome" appearance with subepithelial deposits on EM. - granular appearance on IF |
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Podocyte effacement
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Minimal change Dz
- Most common nephrotic syndrome in kids - Tx: corticosteroids |
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You see nothing on LM. What glomerular pathology could still be present
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1) Minimal change disease
- would see podocyte effacement on EM 2) Focal segmental glomerulosclerosis - Just didn't get an affected glomerulus |
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Most common glomerular pathology in HIV patients
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Focal segmental glomerulosclerosis
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