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70 Cards in this Set

  • Front
  • Back
Streak ovaries, coarctation of aorta, horseshoe kidney
Turner's Syndrome

- XO
- Short stature, webbed neck, lymphedema
Sudden swollen/painful big toe joint, tophi
Gout/podagra

Usually d/t hyperuricemia
Swollen, hard, painful finger joints
Osteoarthritis

- Osteophytes in joints
- Involves PIP (Bouchard's nodes) and DIP (Heberden's nodes)
Systolic ejection murmur
(crescendo-decrescendo)
Aortic valve stenosis
Medullary thyroid carcinoma, parathyroid tumor, pheochromocytoma
MEN IIa

"Sipple's syndrome"
Toe extension/fanning upon plantar scrape
Babinski's sign

- Indicates UMN lesion in anyone other than neonates
Unilateral facial dropping involving the forehead
Bell's palsy (LMN CN VII palsy)

- If doesn't involve forehead - stroke
- If bilateral: Guillan-barre syndrome or Lyme Dz
A male with urethritis, conjunctivitis, arthritis
Reiter's syndrome

- reactive arthritis associated with HLA-B27
- a seronegative spondyloarthropathy
- "Can't see, can't pee, can't climb a tree"
Vascular birthmark (Port-wine stain)
Hemangioma

- Benign
- If in ophthalmologic division of CN V, it's associated with Sturge-Weber syndrome --> underlying vascular formation
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Shwartzman reaction

- follows second exposure to endotoxin
Vomiting blood following esophogogastric lacerations
Mallory-Weiss syndrome

- Associated with alcoholics and bulimics
- Must differentiate from Borave Syndrome --> esophageal rupture; surgical emergency
"Waxy" casts with very low urine flow
End stage CKD
WBC casts in urine
Acute pyelonephritis

- WBCs alone indicate cystitis. The cast formation indicates infection is in the kidney
Weight loss, diarrhea, arthritis, fever, adenopathy
Whipple's disease

- Caused by Tropheryma whippelii
"Worst headache of my life!"
Subarachnoid hemorrhage

- Dx: CT scan; if negative, follow with lumbar puncture
- Causes: Berry anneurysm (APKD, etc), AV malformation
Azurophilic granular needles in leukemic blasts

******
Auer rods

- Acute myelogenous leukemia: especially the promyelocytic type)
"Bamboo spine" on xray
Akylosing spondylitis

- Chronic inflammatory arthritis
- seronegative spondyloarthropathy
- HLA-B27
- Presents in males in their 20s
Basophilic nuclear remnants in RBCs
Howell-Jolly boddies

- D/t splenectomy (Sickle cell pts, trauma, etc)
Basophilic stippling of RBCs
1) Lead poisoning

OR

2) Sideroblastic anemia
Bloody tap on LP
Subarachnoid hemorrhage

- test 3rd tube (1st tube always bloody from trauma of LP)
- SA hemorrhage caused by Berry anneurysm, AV malformations)
"Boot-shaped" heart of CXR
Tetralogy of Fallot (RVH)
Branching G+ rods with sulfur granules
Actinomyces israelii
Bronchogenic apical lung tumor
Pancoast tumor

- Can compress sympatheric ganglion --> Horner's syndrome
"Brown" tumor of bone
Hemorrhage (hemosiderin) --> causes brown color of osteolytic cysts

Caused by:
- Hyperparathyroidism
- Osteitis fibrosa cystica (Von-Reckling-Housen syndrome of bone)
Cardiomegally with apical atrophy
Chagas Disease (Trypanosmoa cruzi)

- Late stage of disease
- Causes cardiomegally, megacolon, and megaesophagus
This autoantibody is associated with which disease(s)?

Anti-dsDNA, anti-Smith
SLE-derived renal disease
Cellular crescents in Bowman's capsule
Rapidly progressive crescentic GN
This autoantibody is associated with which disease(s)?

Antihistone
Drug-induced lupus

(also found in 15% of the systemic lupus population)
"Chocolate cysts" of ovary
Endometriosis

- Frequently bilateral
- Cysts filled with coagulated blood
- Also will see "gun powder" stains on peritoneum from blood
This autoantibody is associated with which disease(s)?

Anti-IgG (rheumatoid factor)
Rheumatoid arthritis

RF is an IgM that attacks IgG
Circular groupings of dark tumor cells surrounding pale neurofibrils
Homer Wright rosettes (pseudorosettes)

Caused by:
- Adrenal neuroblastoma
- Medulloblastoma (brain)
- Ewing sarcoma

-Don't confuse with perivascular rosettes
This autoantibody is associated with which disease(s)?

Anticentromere
CREST syndrome (Scleroderma)

"Crest = antiCentromere"
Perivascular (pseudo)rosettes or tumor cells
Apendimoma
This autoantibody is associated with which disease(s)?

Anti-Scl-70 (anti-DNA topoisomerase I)
Scleroderma (diffuse)
Colonies of mucoid pseudomonas in lungs
Cystic fibrosis

- CFTR mutation in Caucasians
- Results in fat-soluble vitamin deficiency (decreased pancreatic fn), and mucus plugs
This autoantibody is associated with which disease(s)?

Antimitochondrial
Primary biliary cirrhosis
Rectangular, crystal-like, cytoplasmic inclusions in Leydig cells
Reinke crystals (Leydig cell tumor)
This autoantibody is associated with which disease(s)?

Antigliadin, antiendomysial
Celiac disease
Renal epithelial casts in urine
Acute toxic/viral nephritis
This autoantibody is associated with which disease(s)?

Anti-basement membrane
Goodpasture's syndrome
Rib notching
Coarctation of the aorta
This autoantibody is associated with which disease(s)?

Anti-desmoglein
Pemphigus vulgaris
Sheets of medium-sized lymphoid cells

("starry sky" appearance on histology)
Burkitt's lymphoma

- t(8:14), c-myc activation
- associated with EBV
This autoantibody is associated with which disease(s)?

Antimicrosomal, antithryoglobulin
Hashimoto's thyroiditis
Silver-staining spherical aggregation of tau proteins in neurons
Pick bodies

- Pick's disease: progressive dementia, similar to Alzheimer's
This autoantibody is associated with which disease(s)?

Anti-Jo-1
Polymyositis, dermatomyositis
"Soap bubble" in femur or tibia on xray
Giant cell tumor of the bone

- generally benign
This autoantibody is associated with which disease(s)?

Anti-SS-A (anti-Ro)
Sjogren's syndrome
SLE
"Spikes" on basement membrane, "dome-like" endothelial deposits
Membranous glomerulonephritis

- may progress to nephrotic syndrome
This autoantibody is associated with which disease(s)?

Anti-SS-B (Anti-La)
Sjogren's syndrome
SLE
Stacks of red blood cells
Rouleaux formation

- Multiple myeloma
- High ESR
This autoantibody is associated with which disease(s)?

Anti-U1 RNP (ribonucleoprotein)
Mixed connective tissue disease
Stippled vaginal epithelial cells
"Clue cells" a/w Gardnerella vaginalis
This autoantibody is associated with which disease(s)?

Amti-smooth muscle
Autoimmune hepatitis
"Tennis racket" shaped cytoplasmic organelles on EM in Langerhans cells
Birbeck granules

- histiocytosis X --> eosinophilic granuloma
This autoantibody is associated with which disease(s)?

Anti-glutamate decarboxylase
Type 1 diabetes mellitus
Thrombi made of white/red layers
Lines of Zahn (arterial thrombus, layers of platelets/RBCs)
This autoantibody is associated with which disease(s)?

c-ANCA
Wegner's granulomatosis

c-ANCA = cytoplasmic anti-neutrophil cytoplasmic antibody
"Thumb sign" on lateral xray
Epiglottitis (H. influnezae type B)
This autoantibody is associated with which disease(s)?

p-ANCA
Various vasculidities
- microscopic polyangitis
- Churg-Strauss syndrome

p-ANCA = periplasmic-ANCA
Thyroid-like appearance of kidney
Chronic bacterial pyelonephritis
This autoantibody is associated with which disease(s)?

mpo-ANCA
Pauci-immune crescentic glomerulonephritis

mpo-ANCA = myeloperoxidase ANCA
"Tram-tracking" appearance on LM
Membranoproliferative glomerulonephritis
This autoantibody is associated with which disease(s)?

Anti-TSH receptor
Grave's Dz

**Unique b/c Ab STIMULATES the receptor --> hyperthyroidism**
Triglyceride accumulation in liver cells vacuoles
Fatty liver disease (alcoholic or metabolic syndrome)
This autoantibody is associated with which disease(s)?

Anti-ACh receptor
Myasthenia Gravis
WBCs that look "smudged"
CLL

- almost always B cell
- affects the elderly
Positive ANA

What diseases have this?
SLE
Sjogrens
Scleroderma
Polymyositis
Dermatomyositis
RA
Juvenile arthritis
Mixed CT disease
"Wire loop" glomerular appearance on LM
Lupus nephropathy
Yellow CSF
Xanthochromia

- caused by subarachnoid hemorrhage