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99 Cards in this Set
- Front
- Back
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***Amyloid***
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Match Amyloid Type to Protein
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Primary
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AL
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Secondary
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AA
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Senile cardiac
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Transthyretin
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Diabetes mellitus type 2
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Amylin
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Medullary carcinoma of the thyroid
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A-CAL
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Alzheimer’s disease
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β-amyloid
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Dialysis-associated
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β2-microglobulin
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***Amyloid***
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Match Amyloid Type to Protein Derivation
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Types
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Derived from
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Primary
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Ig light chains (multiple myeloma)
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Secondary
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Serum amyloid-associated (SAA) protein (chronic reactant. inflammatory disease)
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Senile cardiac
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AF
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Diabetes mellitus type 2
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AE
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Medullary carcinoma of the thyroid
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Calcitonin
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Alzheimer’s disease
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Amyloid precursor protein (APP)
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Dialysis-associated
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MHC class I proteins
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***Cancer/Disease Association***
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Name Cancer for given Disease
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Down syndrome
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ALL (we ALL fall Down),neoplasms AML
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Xeroderma pigmentosum, albinism
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Melanoma, basal cell carcinoma, and especially squamous cell carcinomas of skin
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Chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants
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Gastric adenocarcinoma
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Tuberous sclerosis (facial angiofibroma, seizures, mental retardation)
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Astrocytoma, angiomyo lipoma, and cardiac rhabdomyoma
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Actinic keratosis
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Squamous cell carcinoma of skin
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Barrett’s esophagus (chronic GI reflux)
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Esophageal adenocarcinoma
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Plummer-Vinson syndrome (atrophic glossitis, esophageal webs, anemia; all due to iron deficiency)
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Squamous cell carcinoma of esophagus
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Cirrhosis (alcoholic, hepatitis B or C)
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Hepatocellular carcinoma
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Ulcerative colitis
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Colonic adenocarcinoma
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Paget’s disease of bone
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2° osteosarcoma and fibrosarcoma
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Immunodeficiency states
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Malignant lymphomas
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AIDS
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Aggressive malignant lymphomas (non-Hodgkin’s) and Kaposi’s sarcoma
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Autoimmune diseases (e.g., Hashimoto’s thyroiditis, myasthenia gravis)
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Benign and malignant lymphomas
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Acanthosis nigricans (hyperpigmentation and epidermal thickening)
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Visceral malignancy (stomach, lung, breast,uterus)
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Dysplastic nevus
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Malignant melanoma
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Radiation exposure
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Sarcoma
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***Oncogenes***
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Associated Tumor
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abl
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CML
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c-myc
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Burkitt's Lymphoma
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bcl-2
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Follicular and undifferentiated lympomas (inhibits apoptosis)
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erb-B2
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Breast, ovarian, and gastric carcinomas
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ras
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Colon carcinoma
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L-myc
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Lung tumor
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N-myc
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Neuroblastoma
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ret
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Multiple endocrine neoplasia (MEN) types II and III
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c-kit
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Gastrointestinal stromal tumor (GIST)
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***Translocation***
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Associated disorder
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t(9;22)
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CML (bcr-abl hybrid))
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t(8;14)
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Burkitt’s lymphoma (c-myc activation)
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t(14;18)
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Follicular lymphomas (bcl-2 activation)
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t(15;17)
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M3 type of AML (responsive to all-trans retinoic acid)
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t(11;22)
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Ewing’s sarcoma
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t(11;14)
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Mantle cell lymphoma
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Tumor Marker
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Tumor
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PSA
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Prostate-specific antigen. Used to screen for prostate carcinoma.
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Prostatic acid phosphatase
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Prostate carcinoma.
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CEA
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Carcinoembryonic antigen. Very nonspecific but produced by ~70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas.
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α-fetoprotein
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Normally made by fetus. Hepatocellular carcinomas. Nonseminomatous germ cell tumors of the testis (e.g., yolk sac tumor).
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β-hCG
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Hydatidiform moles, Choriocarcinomas, and Gestational trophoblastic tumors.
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CA-125
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Ovarian, malignant epithelial tumors.
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S-100
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Melanoma, neural tumors, astrocytomas.
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Alkaline phosphatase
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Metastases to bone, obstructive biliary disease, Paget’s disease of bone.
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Bombesin
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Neuroblastoma, lung and gastric cancer.
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TRAP
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Tartrate-resistant acid phosphatase. Hairy cell leukemia––a B-cell neoplasm.
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CA-19-9
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Pancreatic adenocarcinoma.
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***Virus***
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Associated cancer
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HTLV-1
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Adult T-cell leukemia
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HBV, HCV
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Hepatocellular carcinoma
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EBV
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Burkitt’s lymphoma, nasopharyngeal carcinoma
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HPV
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Cervical carcinoma (16, 18), penile/anal carcinoma
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HHV-8
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Kaposi’s sarcoma, body cavity fluid B-cell lymphoma
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***Toxin***
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Affected organ
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Aflatoxins
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Liver (hepatocellular carcinoma)
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Vinyl chloride
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Liver (angiosarcoma)
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CCl4
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Liver (centrilobular necrosis, fatty change)
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Nitrosamines (e.g., in smoked foods)
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Esophagus, stomach
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Cigarette smoke
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Larynx, lung, renal cell carcinoma, transitional cell carcinoma
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Asbestos
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Lung (mesothelioma and bronchogenic carcinoma)
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Arsenic
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Skin (squamous cell carcinoma)
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Naphthalene (aniline) dyes
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Bladder (transitional cell carcinoma)
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Alkylating agents
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Blood (leukemia)
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Tumor suppressor genes
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Chromosome / Associated Tumor
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Rb
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13q / Retinoblastoma, osteosarcoma
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BRCA1
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17q / Breast and ovarian cancer
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BRCA2
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13q / Breast cancer
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p53
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17p / Most human cancers, Li-Fraumeni syndrome
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p16
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9p / Melanoma
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APC
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5q / Colorectal cancer
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WT1
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11p / Wilms’ tumor
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NF1
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17q / Neurofibromatosis type 1
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NF2
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22q / Neurofibromatosis type 2
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DPC
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18q / Pancreatic cancer
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DCC
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18q / Colon cancer
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