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6 Cards in this Set

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The following HLA subtypes are associated with what pathological findings...?

1. B27

2. B8
1. Psoriasis
Ankylosing spondylytis
Inflammatiry bowel disease
Reiter's Syndrome
"PAIR"

2. Graves disease, celiac sprue
The following HLA subtypes are associated with what pathological findings...?

1. DR2
2. DR3
3. DR4
4. DR5
5. DR7
1. Multiple sclerosis, hay fever, SLE, good Pasteures

2. Diabetes Mellitus Type I

3. Rheumatoid Arthritis, daibetes mellitus type 1

4. Pernicious anemia -> B12 deficiency, Hashimotos thyroiditis

5. Steroid responsive neprhotic syndrome
What are the major diagnostic uses for the following enzyme markers...?

1. Aminotransferases (AST/ALT)

2. GGT (y-guanyl transferase)

3. Alkaline phosphatase

4. Amylase
1. myocardial infarction (AST only)
Viral hepatitis (ALT>AST)
Alcoholic hepatitis (AST> ALT)

2. various liver diseases

3. bone disease (Paget's bone disease), obstrucive liver disease (hepatocellular carcinoma)

4. acute pancratitis, mumps
What are the major diagnostic uses for the following enzyme markers...?

1. lipase

2. CPK

3. LDH-1 (lactate dehydrogenase function)

4. Ceruloplasmin (decreased levels)
1. acute pancreatitis

2. muscle disorders (eg. Duchennes muscular dystrophy) and MI (CPK-MB)

3. MI (LDH-1> LDH-2)

4. Wilson's disease
What pathological findings are associated with the following amyloid deposits...?

1. AL

2. AA
1. Amyloid light chain; seen in plasma cell dyscrasias (multiple myeloma, Waldenstrom's); often fatal

2. From serum amyloid associated protein, acquired secondary to chronic inflammatory disorder; familial variants exist
What pathological findings are associated with the following amyloid deposits...?

1. ATTR

2. AB (beta)

3. B2 microglobulin
1. from transthyretin, a serum transport protein; familial and acquired in the elderly

2. major compnent of Alzheimers plaques

3. deposits in tendons and joints of dialysis patients