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34 Cards in this Set
- Front
- Back
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What parts of pathogens can anti-microbials target?
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- Cell wall synthesis: peptidoglycan synthesis or cross-linking
- Folic acid synthesis (DNA methylation) - DNA topoisomerases - Damage DNA - mRNA synthesis (RNA polymerase) - Protein synthesis (50S or 30S subunit) |
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Which types of drugs target peptidoglycan cross-linking?
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- Penicillinase-sensitive penicillins
- Penicillinase-resistant penicillins - Antipseudomonals - Cephalosporins - Carbapenems - Monobactams |
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What are the penicillinase-sensitive penicillins that affect peptidoglycan cross-linking?
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- Penicillin G, V
- Ampicillin - Amoxicillin |
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What are the penicillinase-resistant penicillins that affect peptidoglycan cross-linking?
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- Oxacillin
- Nafcillin - Dicloxacillin |
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What are the antipseudomonals that affect peptidoglycan cross-linking?
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- Ticarcillin
- Piperacillin |
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What are the cephalosporins that affect peptidoglycan cross-linking?
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1st - Cephazolin, etc
2nd - Cefoxitin, etc 3rd - Ceftriaxone, etc 4th - Cefepime 5th - Ceftaroline |
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What are the carbapenems that affect peptidoglycan cross-linking?
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- Imipenem
- Meropenem - Ertapenem - Doripenem |
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What are the monobactams that affect peptidoglycan cross-linking?
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Aztreonam
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Which drugs target peptidoglycan synthesis (cell wall)?
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Glycopeptides
- Vancomycin - Bacitracin |
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What are the drugs that target folic acid synthesis (DNA methylation)?
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Sulfonamides
- Sulfamethoxazole - Sulfisoxazole - Sulfadiazine Trimethoprim |
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What are the drugs that target DNA topoisomerases?
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Fluoroquinolones
- Ciprofloxacin - Levofloxacin - Etc Quinolone - Nalidixic Acid |
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What are the drugs that damage DNA?
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Metronidazole
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What are the drugs that target mRNA synthesis (RNA polymerase)?
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Rifampin
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What are the drugs that target the 50S subunit in protein synthesis?
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Chloramphenicol
Clindamycin Linezolid Macrolides - Azithromycin - Clarithromycin - Erythromycin Streptogramins - Quinupristin - Dalfopristin |
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What are the drugs that target the 30S subunit in protein synthesis?
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Aminoglycosides
- Gentamicin - Neomycin - Amikacin - Tobramycin - Streptomycin Tetracyclines - Tetracycline - Doxycycline - Minocycline |
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Type / function of:
- Ciprofloxacin - Levofloxacin |
Fluoroquinolones - inhibit DNA topoisomerases
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Type / function of:
- Metronidazole |
Damages DNA
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Type / function of:
- Vancomycin - Bacitracin |
Glycopeptides
- Inhibit peptidoglycan synthesis / cell wall synthesis |
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Type / function of:
- Sulfamethoxazole - Sulfixoxazole - Sulfadiazine |
Sulfonamides
- Inhibits Folic Acid Synthesis / DNA methylation |
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Type / function of:
- Rifampin |
Inhibits mRNA synthesis (RNA polymerase)
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Type / function of:
- Gentamicin - Neomycin - Amikacin - Tobramycin - Streptomycin |
Aminoglycosides
- Inhibit 30S subunit of protein synthesis |
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Type / function of:
- Ticarcillin - Piperacillin |
Antipseudomonals
- Inhibit peptidoglycan cross-linking / cell wall synthesis |
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Type / function of:
- Aztreonam |
Monobactam
- Inhibit peptidoglycan cross-linking / cell wall synthesis |
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Type / function of:
- Trimethoprim |
Inhibits folic acid synthesis / DNA methylation
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Type / function of:
- Chloramphenicol - Clindamycin - Linezolid |
Inhibit 50S subunit of protein synthesis
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Type / function of:
- Tetracycline - Doxycycline - Minocycline |
Tetracyclines
- Inhibit 30S subunit of protein synthesis |
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Type / function of:
- Imipenem - Meropenem - Ertapenem - Doripenem |
Carbapenems
- Inhibit peptidoglycan cross-linking / cell wall synthesis |
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Type / function of:
- Azithromycin - Clarithromycin - Erythromycin |
Macrolides
- Inhibit 50S subunit of protein synthesis |
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Type / function of:
- Oxacillin - Nafcillin - Dicloxacillin |
Penicillinase-resistant penicillins
- Inhibit peptidoglycan cross-linking / cell wall synthesis |
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Type / function of:
- Penicillin G, V - Ampicillin - Amoxicillin |
Penicillinase-sensitive penicillins
- Inhibit peptidoglycan cross-linking / cell wall synthesis |
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Type / function of:
- Nalidixic Acid |
Quinolone
- Inhibits DNA topoisomerase |
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Type / function of:
- Quinupristin - Dalfopristin |
Streptogramins
- Inhibit 50S subunit of protein synthesis |
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Type / function of:
- Cephazolin - Cefoxitin - Ceftriaxone - Cefipime - Ceftaroline |
Cephalosporins (I-V)
- Inhibit peptidoglycan cross-linking / cell wall synthesis |
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179
Penicillin G, V |
179
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