Fa - Immunology

Front 1

3 functions of a LN:

Back 1

1. nonspecific filtration by mP's

2. storage of B and T cells

3. site of immune response activation (e.g. of CD8+'s, Th1, Th2, etc.)

Front 2

paracortex of LN's ~~

(2)

Back 2

1. housing of T cells

2. endothelial veins through which T and B cells enter blood

Front 3

marginal zone of spleen contains:

(2)

Back 3

1. APC's (presenting blood-borne antigens here)

2. specialized B cells

Front 4

splenic dysfunction => inc. susceptibility to encapsulated bact. b/c of:

Back 4

dec. IgM =>

=> dec. Complement activation



SHiNE SKiS

Front 5

3 effects of splenectomy:

Back 5

1. Howell-Jolly bodies
(nuclear remnants in new RBC's)

2. target cells

3. thrombocytosis
(excess plats)

Front 6

loci of MHC Class I =

(3)

Back 6

HLA-A, -B, and -C

Front 7

loci of MHC Class II =

(3)

Back 7

HLA-DP, -DQ, -DR

Front 8

role of B cells:

(4)

Back 8

1. recognize antigen

2. undergo somatic hypermutation to optimize antigen specificity

3. produce AB's

4. maintain immunologic memory => faster future response

Front 9

role of CD4+'s =

(2)

Back 9

1. 2nd activation signal for B cells (CD40L)

2. produce cytokines that activate other cells of the IS
(like CD8+'s)

Front 10

CD8's induce apoptosis in:

(3)

Back 10

1. virus-infected cells

2. neoplastic cells

3. donor graft cells

Front 11

5 features of Fc region of AB's:

Back 11

1. Constant

2. Carboxy terminal

3. Complement-binding

4. Carb side chains

5. determines isotype (IgM, etc.)

Front 12

3 means of AB diversity:

Back 12

1. random recombination of VJ (light-chain) or V(D)J (heavy) genes

2. random combo of heavy chains with light chains

3. somatic hypermutation (following antigen stimulation)

Front 13

why does iron need to be sequestered during an inf?

Back 13

b/c microbes will seek it for use as cofactor

Front 14

C1 esterase inhibitor deficiency causes:

Back 14

hereditary angioedema

- ACEI's contraindicated

Front 15

C3 deficiency increases risk of:

(2)

Back 15

1. severe, recurrent pyogenic sinus and Resp. tract inf's

2. susceptibility to Type III HSR's

Front 16

C5-C9 deficiencies increase susceptibility to:

Back 16

recurrent Neisseria *bacteremia*

Front 17

ALL cells have MHC Class I except for:

Back 17

mature RBC's

Front 18

attenuated vaccines induce:

Back 18

a cellular (T-cell response)

- contra in preg and immu-comp
(may revert to live form)

(vs. humoral response with inactivated/killed vaccines)

Front 19

inactivated or killed vaccines induce:

Back 19

humoral immunity

- weaker response than that generated by attenuated vaccines; requires periodic booster

Front 20

disorder associated with anti-ACH r' AB's =

Back 20

MG

Front 21

disorder associated with anti-basement memb. AB's =

Back 21

Goodpasture syndrome

Front 22

disorders associated with anti-cardiolipin, anticoagulant AB's =

(2)

Back 22

1. SLE

2. antiphospholipid syndrome (seen in subset of SLE)

Front 23

disorder associated with anti-centromere AB's =

Back 23

limited/local-type scleroderma

(CREST syndrome)

Front 24

disorder associated with anti-desmoglein AB's =

Back 24

Pemphigus Vulgaris

Front 25

disorder associated with anti-dsDNA, anti-Smith AB's =

Back 25

SLE

Front 26

disorder associated with anti-glutamate decarboxylase AB's =

Back 26

DM1

Front 27

disorder associated with anti-hemidesmosome AB's =

Back 27

Bullous Pemphigoid

Front 28

disorder associated with anti-histone AB's =

Back 28

DILE

Front 29

2 disorders associated with anti-JO-1, anti-SRP, anti-Mi-2 AB's =

Back 29

1. dermatomyositis

2. polymyositis

Front 30

disorder associated with anti-microsomal, anti-thyroglobulin AB's =

Back 30

Hashimoto thyroiditis

Front 31

disorder associated with anti-mit. AB's =

Back 31

primary biliary cirrhosis

Front 32

disorder associated with anti-nuclear AB's =

Back 32

SLE

- otherwise, nonspecific

Front 33

disorder associated with anti-Scl-70 AB's =

(i.e. anti-DNA topoisomerase 1 AB's)

Back 33

diffuse-type Scleroderma

Front 34

disorder associated with anti-SM AB's =

Back 34

AI hepatitis

Front 35

disorder associated with anti-SSA, anti-SSB
(anti-Ro, anti-La) AB's =

Back 35

Sjogren syndrome

Front 36

disorder associated with anti-TSH r' AB's =

Back 36

Graves dz

Front 37

disorder associated with anti-U1 RNP AB's =

(ribonucleoprotein)

Back 37

Mixed CT dz

Front 38

disorder associated with c-ANCA AB's =

(aka PR3-ANCA AB's)

Back 38

Gran Poly

(granulomatosis polyangiitis / Wegener's)

Front 39

disorder associated with IgA antiendomysial, IgA anti-tissue transglutimase AB's =

Back 39

Celiac dz

Front 40

2 disorders associated with p-ANCA AB's =

(aka MPO-ANCA)

Back 40

1. microscopic polyangiitis

2. Churg-Strauss syndrome

Front 41

disorder associated with anti-CCP AB's =

Back 41

rheumatoid arthritis (for dx)

(~~ RF as well)

Front 42

Sirolimus (Rapamycin) mechanism/effect:

Back 42

blocks T-cell activation and B-cell differentiation

by preventing IL-2 signal transduction

- non-nephrotoxic

Front 43

chronic immune suppression increases risk of:

(2)

Back 43

1. inf.

2. malignancy

Front 44

recombinant cytokine to treat anemia (check FA)

Back 44

Epoetin alfa (~EPO)

Front 45

2 recombinant cytokines to treat thrombocytopenia:

Back 45

1. Thrombopoetin

2. Oprelvekin (~IL-II)

Front 46

2 recombinant cytokines for recovery of bone marrow:

Back 46

"-stims"


1. Filgrastim
(granulocyte CSF)

2. Sargramostim
(granulocyte-mP CSF)

Front 47

recombinant cytokine to treat RCC, mets melanoma:

Back 47

Aldesleukin

(~IL-2)

Front 48

MS is treated with:

Back 48

IFN-B

(recombinant cytokine)

Front 49

Chronic Granulomatous dz is treated with:

Back 49

IFN-y

(recombinant cytokine)