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17 Cards in this Set
- Front
- Back
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What cytokines are secreted by Th cells?
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IL-2,4,5,6, gamma-IFN
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What cytokines are secreted by Macrophages?
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IL-1, TNF-alpha, IL6,IL12
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What cytokines are secreted by activated T cells (not specified)?
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IL-3
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What cytokines are secreted by B cells?
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IL-12
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What cytokines are secreted by Th2 (specifically)?
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IL-10
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In general, what are the functions of IL1-5?
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Hot T-Bone stEAk
IL-1: Fever IL-2: T cells IL-3: Bone marrow IL-4: IgE IL-5: IgA |
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Stimulates T cells, B cells, neutrophils, fibroblasts, and epithelial cells; an endogenous pyrogen
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IL-1 (macrophages)
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Stimulates growth of Th and Tc cells
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IL-2 (Th)
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Supports the growth and differentiation of bone marrow stem cells (like GM-CSF)
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IL-3 (activated T cells)
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Promotes growth of B cells. Enhances class switching of IgE and IgG
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IL-4 (Th)
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Promotes differentiation of B cells. Enhances class switching of IgA. stimulates production and activation of eosinophils.
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IL-5 (Th)
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Stimulates production of acute-phase reactants and Igs
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IL-6 (Th, Macrophages)
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Major chemotactic factor for neutrophils
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IL-8 (none listed)
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Stimulates Th2 while inhibiting Th1
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IL-10 (Th2)
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Activates NK cells and Th1 cells
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IL-12 (B cells and Macrophages)
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Stimulates macrophages.
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gamma-interferon (Th)
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Inc IL-2 receptor synthesis by Th cells
Inc B cell proliferation Attracts and activates PMNs stimulates dendritic cell migration to LN |
TNF-alpha (Macrophages)
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