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35 Cards in this Set
- Front
- Back
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What is poorly developed in DiGeorge's syndrome?
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paracortex
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What drains the right arm and right half of head?
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Right lymphatic duct
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What drains most of the body's lymph?
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thoracic duct
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Where are T cells found in the spleen?
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PALS, red pulp
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What occurs at the corticomedullary junction of the spleen?
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Positive and negative selection
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3 major functions of antibody-mediated immunity?
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Host defense against infection (opsonize bacteria)
Allergy (type I) Autoimmunity |
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4 major function sof cell-mediated immunity?
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Host defense agaisnt infection (TB, viruses, fungi)
allergy (type IV) graft and tumor rejection regulation of Ab response |
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All nucleated cells have MHC __
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MHC I
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All antigen-presenting cells have MHC ____
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MHC I,II
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Class __ are the main determinants of organ rejection
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Class I
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ANA
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SLE
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Anti-dsDNA, anti-Sm
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specific for SLE
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Antihistone
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drug-induced lupus
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Anti-IgG (rheumatoid factor which is IgM)
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Rheumatoid arthritis
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Antineutrophil (C-ANCA, P-ANCA)
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Vasculitides
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Anticentromere
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Scleroderma (CREST)
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Anti-Scl-70
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Scleroderma (Diffuse)
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Anti-mitochondrial
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primary biliary cirrhosis
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Antigliadin
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Celiac disease
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Anti-basement membrane
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goodpasture's syndrome
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anti-epithelial cell
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pemphigus vulgaris
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antimicrosomal and antithyroglobulin
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hashimoto's thyroiditis
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Anti-Jo-1
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polymyositis, dermatomyositis
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B27
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PAIR
Psoriasis Ankylosing Spondyliasis Inflammatory Bowel Disease Reiter's syndrome |
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B8
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Gravy and Chili in Line 8
Graves' disease Celiac sprue |
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DR2
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Mary's Hens are So Good
Multiple Sclerosis Hay fever SLE Goodpasture's syndrome |
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DR3
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DM I
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DR 4
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Rheumatoid arthritis, DM I
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DR 5
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Hashimoto's thyroiditis, Pernicious anemia
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DR 7
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Steroid-responsive nephrotic syndrome
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Antibody mediated due to presence of preformed antidonor Abs in transplant recipient. Occurs within minutes after transplantation.
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Hyperacute rejection.
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Cell mediated due to Tc against foreign MHCs. Weeks after transplantation. Reversible with immunosuppresants like cyclosporin and OKT3
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Acute rejection
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Antibody-mediated vascular damage. Months to years after transplantation. Irreversible.
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Chronic rejection.
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Grafted immunocompetent T cells proliferate in irradiated immunocompromised host and reject cells with "foreign" proteins.
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Graft-vs-host disease
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Maculopapular rash, jaundice, hepatosplenomegaly, and diarrhea.
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Graft-vs-host disease
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