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49 Cards in this Set
- Front
- Back
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origin/markers of RS cells?
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B cell origin - CD30+, CD15+
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good prognosis in Hodgkins?
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increased lymphocytes, decreased RS cells
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50% of cases of Hodgkin's are associated with what?
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EBV
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what is non-Hodgkin's associated with?
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HIV and immunosuppression
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peak incidence of non-Hodgkin's?
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20-40 years old
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peak incidence of Hodgkin's?
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bimodal distribution - young and old
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most common type of Hodgkin's?
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nodular sclerosing type
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collagen banding, lacunar cells are found in what type of Hodgkin's lymphoma?
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nodular sclerosing type - most common in young women
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numerous RS cells are found in what type of Hodgkin's?
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mixed cellularity (25% of cases)
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Hodgkin's in older males with disseminated disease; poor prognosis?
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lymphocyte depleted
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cell type in SLL, follicular lymphoma (small cleaved cell)?
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B cells
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this is like CLL with focal mass, low grade
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small lymphocytic lymphoma
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most common in children; commonly presents with ALL and mediastinal mass; very aggressive T cell lymphoma
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lymphoblastic lymphoma
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cell type in diffuse large cell lymphoma? who does it affect
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80% B cells; 20% T cells; usually older adults, but 20% occur in children
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starry sky appearance - sheets of lymphocytes with interspersed macrophages?
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Burkitt's lymphoma
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jaw lesion in endemic form in Africa; pelvis or abdomen in sporadic form
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Burkitt's lymphoma
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cell type in Burkitt's lymphoma?
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B cells - most often affects kids
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leukemia most responsive to therapy?
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ALL
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generalized nontender lymphadenopathy in children, lymphoblasts; may spread to CNS and testes. What is the diagnosis and marker?
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ALL; TdT+
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auer rods, myeloblasts, adults
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AML
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leukemia affecting older adults; lymphadenopathy, hepatosplenomegaly, few symptoms, indolent course?
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CLL
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findings on blood smear in CLL?
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smudge cells
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leukemia that can cause warm antibody AI hemolytic anemia?
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CLL
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leukemia that presents with increased neutrophils and metamyelocytes, splenomegaly
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CML
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How do you distinguish CML from leukemoid reaction?
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CML has low leukocytic alkaline phosphatase. Leukemoid reaction has high LAP.
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peroxidase-positive cytoplasmic inclusions in granulocytes and myeloblasts
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Auer rods
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in which type of AML are Auer rods primarily seen?
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acute promyelocytic leukemia (M3)
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treatment of this leukemia can release Auer rods, causing DIC
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acute promyelocytic leukemia
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monoclonal plasma cell (fried egg appearance) cancer that arises in the marrow and produces large amounts of IgG (55%) or IgA (25%)
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multiple myeloma
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most common primary tumor arising from bone in adults
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multiple myeloma
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these are laminated, concentric, calcific spherules
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psammoma bodies
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where are psammoma bodies seen?
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PSaMMoma:
papillary (thyroid) serous (ovary) meningioma mesothelioma |
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Most common leukemia in persons 0-14 years old
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ALL
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Most common leukemia in persons 15-39 years old
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Acute myelogenous leukemia
Contains auer rods and myeloblasts |
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most common leukemia in persons aged 40-59
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acute myelogenous leukemia
chronic myelogenous leukemia |
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most common leukemia in persons aged over 60 years
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chronic lymphocytic leukemia
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most common overall leukemia regardless of age
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CLL
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what is the genetic abnormality necessary to diagnose CML?
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Philadelphia chromosome
t(9;22) bcr-abl hybrid |
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What is the chromosomal abnormality in Burkitt's lymphoma?
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t(8;14) c-myc activation
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What is the chromosomal abnormality in Follicular lymphomas?
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t(14;18) bcl-2 activation
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What is the chromosomal abnormality in promyelocytic AML?
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t(15;17)
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What is the treatment for promyelocytic AML? What is the mechanism of treatment?
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Retinoic Acid; causes blasts to mature into benign cells
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What is the chromosomal abnormality in Ewing's sarcoma?
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t(11;22)
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What is the chromosomal abnormality in Mantle Cell lymphoma?
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t(11;14)
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elderly patient with generalized non-tender lymphadenopathy. Mature B-cells contain filamentous projections. What is the diagnosis and how is it diagnosed?
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Hairy Cell leukemia diagnosed by staining TRAP positive
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What are Bence Jones proteins and in what disease are they found?
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Ig light chains found in urine; found in multiple myeloma
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what are main findings in multiple myeloma?
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1. punched out, lytic bone lesions on x-ray
2. monoclonal immunoglobulin spike (M protein) on plasma electrophoresis 3. Bence Jones protein 4. Stacked RBCs on blood smear |
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patient presents with localized, non-tender lymphadenopathy with contiguous spread. (S)he has fever, night sweats and weight loss. what is the diagnosis?
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Hodgkin's lymphoma
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young adult has cells of monocyte lineage infiltrating the lung. EM shows intracellular granules resembling tennis rackets.
What is the diagnosis? What are the markers on these cells? |
histiocytosis X
CD1+ |
